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New drug compounds show promise in treating acute myeloid leukemia

Researchers have been struggling for years to find a treatment for patients who have a recurrence of acute myeloid leukemia (AML), an aggressive blood cancer that is one of the most lethal cancers. About 19,520 news cases are diagnosed a year, and about 10,670 people a year die from it, according to the American Cancer Society.

29 Jan 2019

New approach identifies epigenetic changes in leukemia cells for patients undergoing ibrutinib treatment

Many new anti-cancer drugs inhibit proteins that are essential for the proliferation of cancer cells. One example is ibrutinib, an innovative therapy for chronic lymphocytic leukemia first approved in 2014.

29 Jan 2019

Researchers identify marker protein that offers both diagnostic and therapeutic function

Of all gastrointestinal cancers, pancreatic cancer is one of the most aggressive. Because of this, it has a very low 5-year survival rate of just 5% and a median survival time below 6 months. Additionally, treatment is difficult, with only surgery shown to provide a cure. However, the vast majority of patients have tumors that cannot be removed surgically or their cancer is too advanced or spread too far to be treatable.

24 Jan 2019

Researchers reveal important signaling pathway in breast cancer

Researchers at Kanazawa University report in Proceedings of the National Academy of Sciences of the United States of America that a particular signaling pathway in breast-cancer tumors causes cancer cells to divide symmetrically, expanding the tumor. Inhibiting the pathway by drugs could become a strategy for eliminating the cancer cells.

24 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms

Using ultraviolet disinfection technology to reduce the risk of hospital-acquired infections eliminated up to 97.7 percent of pathogens in operating rooms (ORs), according to a study published in the American Journal of Infection Control.

18 Jan 2019

First international consensus on the diagnosis and management of fibromuscular dysplasia

The "First international consensus on the diagnosis and management of fibromuscular dysplasia" (FMD) has been published online first today in Vascular Medicine and the Journal of Hypertension.

17 Jan 2019

Researchers identify promising therapeutic option to treat multiple sclerosis

Researchers at the Medical Center of Johannes Gutenberg University Mainz (JGU) identified an innovative and promising therapeutic option to treat multiple sclerosis.

10 Jan 2019

Study uncovers a protein involved in lung cancer treatment resistance

Lung cancer remains a major cause of mortality across the globe, although we are gaining a deeper understanding of the genetic background behind this disease, including the mutations that promote it.

10 Jan 2019

New mechanism of gene regulation involved in tumor progression discovered

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.

9 Jan 2019

Neurons produced after a stroke fail to develop properly, research finds

Mice produce new neurons in the hippocampus following a stroke that fail to develop properly, finds new research published in JNeurosci. Intervening in the production of these cells may help to mitigate stroke-induced memory impairments.

From Society for Neuroscience 9 Jan 2019

Drug combination has added benefit for patients with melanoma

The German Institute for Quality and Efficiency in Health Care investigated whether the drug combinations of dabrafenib plus trametinib and of encorafenib plus binimetinib have an added benefit in comparison with the appropriate comparator therapies for patients with melanoma.

9 Jan 2019

Johns Hopkins researchers identify new marker for early detection of colorectal cancers

Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers.

7 Jan 2019

Study elucidates how essential amino acid in humans acts as growth signal for cells

A recent study from the Laxman lab elucidates how a small metabolite and amino acid, methionine, acts as a growth signal for cells, by setting into motion a metabolic program for cell proliferation.

7 Jan 2019

A small protein plays key role in how cancer stem cells differentiate

A jagged little protein appears to be key to how cancer stem cells differentiate and enable metastasis, according to researchers at Rice University and the Duke University School of Medicine.

4 Jan 2019

Study explains effects of aging on endothelial health and vascular regenerative capacity

The endothelium plays an important role in cardiovascular regulation, from blood flow to platelet aggregation, immune cell infiltration and demargination.

28 Dec 2018

Molecule discovery could hold the key to novel gene therapies for skin problems

Scientists at the University of Birmingham have discovered a protein that could hold the key to novel gene therapies for skin problems including psoriasis - a common, chronic skin disease that affects over 100 million people worldwide.

20 Dec 2018

Novel ferrocenyl phosphines developed as potent antimalarial drugs

A team of researchers from the Singapore University of Technology and Design and Nanyang Technological University have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death.

20 Dec 2018

Self-powered bandage generates electricity, reduces healing time for skin wounds in rats

Skin has a remarkable ability to heal itself. But in some cases, wounds heal very slowly or not at all, putting a person at risk for chronic pain, infection and scarring. Now, researchers have developed a self-powered bandage that generates an electric field over an injury, dramatically reducing the healing time for skin wounds in rats.

19 Dec 2018

Active ingredient in eye drops shows promise for treating aggressive blood cancer

An active ingredient in eye drops that were being developed for the treatment of a form of eye disease has shown promise for treating an aggressive form of blood cancer. Scientists at the Wellcome Sanger Institute, University of Cambridge, University of Nottingham and their collaborators have found that this compound, which targets an essential cancer gene, could kill leukemia cells without harming non-leukemic blood cells.

19 Dec 2018

Proliferation News and Research

New drug compounds show promise in treating acute myeloid leukemia

New approach identifies epigenetic changes in leukemia cells for patients undergoing ibrutinib treatment

Researchers identify marker protein that offers both diagnostic and therapeutic function

Researchers reveal important signaling pathway in breast cancer

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms

First international consensus on the diagnosis and management of fibromuscular dysplasia

Researchers identify promising therapeutic option to treat multiple sclerosis

Study uncovers a protein involved in lung cancer treatment resistance

New mechanism of gene regulation involved in tumor progression discovered

Neurons produced after a stroke fail to develop properly, research finds

Drug combination has added benefit for patients with melanoma

Johns Hopkins researchers identify new marker for early detection of colorectal cancers

Study elucidates how essential amino acid in humans acts as growth signal for cells

A small protein plays key role in how cancer stem cells differentiate

Study explains effects of aging on endothelial health and vascular regenerative capacity

Molecule discovery could hold the key to novel gene therapies for skin problems

Novel ferrocenyl phosphines developed as potent antimalarial drugs

Self-powered bandage generates electricity, reduces healing time for skin wounds in rats

Active ingredient in eye drops shows promise for treating aggressive blood cancer

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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