Genetic News and Research

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Interleukin-18 plays a key role in inflammation

The naturally occurring cytokine interleukin-18, or IL-18, plays a key role in inflammation and has been implicated in serious inflammatory diseases for which the prognosis is poor and there are currently limited treatment options.

7 Sep 2012

New findings establish connection between microRNAs and cellular metabolism

New findings establish a connection between microRNAs and cellular metabolism, suggesting that a drug designed to inhibit these tiny molecules -- once considered to be "junk" DNA -- would have a positive effect against obesity.

7 Sep 2012

Researchers turn skin cells into embryonic Sertoli-like cells

Using a stepwise trans-differentiation process, Whitehead Institute researchers have turned skin cells into embryonic Sertoli-like cells.

7 Sep 2012

Clathrin protein plays a key role in cell division

A protein called "clathrin," which is found in every human cell and plays a critical role in transporting materials within them, also plays a key role in cell division, according to new research at the University of California, San Francisco.

7 Sep 2012

Researchers discover genetic cause of hereditary spastic ataxia

Researchers from the Guy Rouleau Laboratory affiliated with the CHUM Research Centre and the CHU-Sainte-Justine Research Centre have discovered the genetic cause of a rare disease reported only in patients originating from Newfoundland: hereditary spastic ataxia (HSA).

7 Sep 2012

Scientists complete comprehensive map of genetic mutations linked to small cell lung cancers

Scientists have completed a comprehensive map of genetic mutations linked to an aggressive and lethal type of lung cancer.

6 Sep 2012

New approach can help researchers study genetic variations associated with disease

With the ability to sequence human genes comes an onslaught of raw material about the genetic characteristics that distinguish us, and wading through these reserves of data poses a major challenge for life scientists. Researchers at Roswell Park Cancer Institute (RPCI) and the Center for Human Genome Variation at Duke University Medical Center (DUMC) have developed an approach for analyzing data that can help researchers studying genetic factors in disease to quickly cull out relevant genetic patterns and identify variants that lead to particular disorders.

6 Sep 2012

Eliminating jnk3 enzyme leads to 90% reduction in Alzheimer's plaque-forming compounds

Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer's disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer's disease.

6 Sep 2012

Sleep disruptions may be among the first signs of Alzheimer's

Sleep disruptions may be among the earliest indicators of Alzheimer's disease, scientists at Washington University School of Medicine in St. Louis report Sept. 5 in Science Translational Medicine.

6 Sep 2012

Study sheds light on why women gain fat following menopause

A high-fat diet triggers chemical reactions in female mice that could explain why women are more likely than men to gain fat in the abdomen after eating excess saturated fat, new research suggests. The study also sheds light on why women gain fat following menopause.

6 Sep 2012

CSHL publishes genome-wide analysis of transcripts produced within human cells

Most people understand genes to be specific segments of DNA that determine traits or diseases that are inherited. Textbooks suggest that genes are copied into RNA molecules, which are then used as templates for making protein - the highly diverse set of molecules that act as building blocks and engines of our cells. The truth, it now appears, is not so simple.

6 Sep 2012

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.

6 Sep 2012

Akonni receives NSF's Phase 2 SBIR Grant to develop Lab-on-a-Film microarray

Akonni Biosystems, a life science tools / molecular diagnostics company that develops, manufactures, and plans to market molecular testing devices for diagnosing infectious diseases and human genetic disorders, announced today the receipt of a $498,780 Phase 2 SBIR Grant from the National Science Foundation (NSF).

6 Sep 2012

Study sheds new light on why most bone marrow transplant patients suffer acute GVHD

A team of scientists led by a bone marrow transplant researcher at Fred Hutchinson Cancer Research Center has shed new light on why most bone marrow transplant patients who receive tissue-matched cells from unrelated donors still suffer acute graft-versus-host disease (GVHD).

6 Sep 2012

Two UNC autism researchers receive $12.6 million in grants from ACE program

Two autism researchers in the University of North Carolina School of Medicine have each been awarded $12.6 million grants in the latest round of funding from the National Institutes of Health's Autism Centers of Excellence (ACE) research program.

6 Sep 2012

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

Researchers have discovered two gene variants that raise the risk of the pediatric cancer neuroblastoma. Using automated technology to perform genome-wide association studies on DNA from thousands of subjects, the study broadens understanding of how gene changes may make a child susceptible to this early childhood cancer, as well as causing a tumor to progress.

5 Sep 2012

BioReliance introduces Reconstructed Skin Micronucleus Assay to detect DNA damage

Sigma-Aldrich Corporation today announced that its recent acquisition, BioReliance, the biopharma and early development services business under SAFC, will introduce a new assay to detect DNA damage from products with dermal routes of exposure. The Reconstructed Skin Micronucleus (RSMN) Assay represents the first commercial offering of a Genetic Toxicology assay using three-dimensional tissue models.

5 Sep 2012

Scientists identify three new genes associated with Primary Angle Closure Glaucoma

Singapore scientists have identified three new genes associated with Primary Angle Closure Glaucoma (PACG), a leading cause of blindness in Chinese people. PACG affects 15 million people worldwide, 80% of whom live in Asia.

5 Sep 2012

More findings on genetic complexity behind type 2 diabetes

Using a new method, diabetes researchers at Lund University, Sweden, have been able to reveal more of the genetic complexity behind type 2 diabetes.

5 Sep 2012

NIH funded researchers identify and explore different aspects of anesthesia

Anesthesia helps many of us during our lives, whether we need a local painkiller at the dentist, numbing eye drops for laser vision correction or general anesthesia for major surgery. But even though anesthetics have been used in many procedures for more than 150 years, doctors and scientists still don't know exactly how these medicines work in the body.

5 Sep 2012

Genetic News and Research

Interleukin-18 plays a key role in inflammation

New findings establish connection between microRNAs and cellular metabolism

Researchers turn skin cells into embryonic Sertoli-like cells

Clathrin protein plays a key role in cell division

Researchers discover genetic cause of hereditary spastic ataxia

Scientists complete comprehensive map of genetic mutations linked to small cell lung cancers

New approach can help researchers study genetic variations associated with disease

Eliminating jnk3 enzyme leads to 90% reduction in Alzheimer's plaque-forming compounds

Sleep disruptions may be among the first signs of Alzheimer's

Study sheds light on why women gain fat following menopause

CSHL publishes genome-wide analysis of transcripts produced within human cells

Scripps Florida designs new compound that shows promise against tremor ataxia syndrome

Akonni receives NSF's Phase 2 SBIR Grant to develop Lab-on-a-Film microarray

Study sheds new light on why most bone marrow transplant patients suffer acute GVHD

Two UNC autism researchers receive $12.6 million in grants from ACE program

Researchers discover two gene variants that raise risk of pediatric cancer neuroblastoma

BioReliance introduces Reconstructed Skin Micronucleus Assay to detect DNA damage

Scientists identify three new genes associated with Primary Angle Closure Glaucoma

More findings on genetic complexity behind type 2 diabetes

NIH funded researchers identify and explore different aspects of anesthesia

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