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Cryo-EM reveals structural dynamics of RNAP-DNA interactions during transcription initiation

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble, so that one exposed DNA strand can be copied into a complementary RNA strand.

10 Jul 2024

Click-like chemistry enables rapid development of LNPs for enhanced mRNA delivery

Imagine a scenario where a skilled hacker must upload critical software to update a central server and thwart a potentially lethal virus from wreaking havoc across a vast computer network.

10 Jul 2024

Antonin (Tony) de Fougerolles appointed as new Chair of etherna

etherna, a leading mRNA technologies company, today announced the appointment of Antonin (Tony) de Fougerolles as Chair. Tony has served as an Independent Board Member since January 2023.

From etherna 10 Jul 2024

Efficient multi-site genome editing with retron-derived multitrons

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

Exploring the benefits of miniaturizing NGS library preparation

In this interview, Huw Rees, a field application scientist at SPT Labtech, discusses the benefits of miniaturization in NGS library preparation and how using mosquito® can give you more value for your money.

From SPT Labtech 10 Jul 2024

Why the election may slow plans to replace lead pipes

With the Environmental Protection Agency's latest — and strictest — plan to minimize the risk of Americans drinking lead-contaminated water on the horizon, the debate over whether the rules go too far or not nearly far enough is reaching a tipping point.

10 Jul 2024

Understanding alcohol advertising effects on risky drinkers during sports events

New Edith Cowan University (ECU) research shows exposure to alcohol advertisements during national sports broadcasts, particularly those that feature a preferred beverage, significantly increases cravings in people with risky drinking behaviors.

10 Jul 2024

Experts identify sex and gender differences in cognitive resistance and resilience to Alzheimer's disease

Researchers investigated sex-related and gender-specific resistance and resilience factors in Alzheimer's disease.

10 Jul 2024

New study highlights impact of sleep disturbances on COVID-19 and long COVID

The influence of pre-existing sleep disturbances on coronavirus disease 2019 (COVID-19) susceptibility, severity, and long-term effects.

10 Jul 2024

Researchers call for ethical guidance on use of AI in healthcare

The ethical implications of deploying Large Language Models (LLMs) in healthcare through a systematic review.

10 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

World’s first map of human brain lipids created

Scientists have found that 93% of the lipids in brain tissue are distributed differently in the white and gray matter, the subcortex, the visual and motor cortices, and the prefrontal cortex, which is responsible for decision-making, social behavior, and other functions.

10 Jul 2024