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Waning Japanese encephalitis immunity linked to more severe dengue illness

Scientists from Duke-NUS Medical School, in collaboration with researchers in Nepal, have found that waning immunity to Japanese encephalitis virus (JEV) may increase the risk of more severe dengue disease in humans.

13 Sep 2025

Subcutaneous amivantamab plus lazertinib yields high response in EGFR-mutant lung cancer

A new analysis from the PALOMA-2 study presented today shows that subcutaneous administration of amivantamab every four weeks (Q4W), in combination with daily oral lazertinib, yields a high objective response rate in patients with previously untreated EGFR-mutated advanced non-small cell lung cancer (NSCLC).

10 Sep 2025

Global climate warming fuels rising dengue burden across Asia and the Americas

Warmer weather across the globe is reshaping the landscape of human health. Case in point: dengue fever, a mosquito-borne disease once confined largely to the tropics which often brings flu-like symptoms and without proper medical care can escalate to severe bleeding, organ failure, and even death.

9 Sep 2025

What diet pattern worsens inflammatory bowel disease?

Researchers compare the different effects of pro-inflammatory dietary patterns on inflammatory bowel disease severity.

9 Sep 2025

Dengue infection leaves lasting genetic imprint on immunity

Just as a computer's operating system can be rewritten after a major update, dengue infection can 're-programme' the body's immune system, leaving a long-lasting genetic imprint that influences how people respond to future infections-an effect not seen with vaccination.

9 Sep 2025

Aspirin therapy does not help people suffering from chronic rhinosinusitis with nasal polyps

A randomized placebo-controlled Finnish study showed that aspirin therapy does not provide significant relief for people suffering from chronic rhinosinusitis with nasal polyps who are hypersensitive to non-steroidal anti-inflammatory drugs (NSAIDs).

8 Sep 2025

No advantage found in modulating antiplatelet therapy intensity after complex stenting

There was no benefit to modulating the intensity of antiplatelet therapy compared with standard antiplatelet therapy in high-risk patients who had undergone complex stenting procedures, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

4 Sep 2025

Trial compares the use of blood thinners after stenting in patients with acute coronary syndromes

Noninferiority was not demonstrated for death and ischemic events between P2Y12 inhibitor monotherapy and dual antiplatelet therapy (DAPT) given for 12 months after stenting in patients with acute coronary syndromes (ACS), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

3 Sep 2025

Dual antiplatelet therapy shows no benefit over aspirin after CABG in patients with acute coronary syndrome

Dual antiplatelet therapy (DAPT) was not more effective than aspirin alone for the prevention of major adverse cardiovascular events and increased major bleeding in patients with acute coronary syndrome (ACS) who underwent coronary artery bypass grafting (CABG), according to late-breaking research presented in a Hot Line session today at ESC Congress 20251 and simultaneously published in New England Journal of Medicine.

3 Sep 2025

Stopping oral anticoagulation reduces risk after successful atrial fibrillation ablation

Discontinuing oral anticoagulation (OAC) therapy resulted in a lower risk of a composite of stroke, systemic embolism or major bleeding than continuing OAC therapy in patients who had successful ablation for atrial fibrillation at least 12 months previously, according to results from a late-breaking trial presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in The Journal of the American Medical Association.

3 Sep 2025

No clear benefit from surgical left atrial appendage occlusion in non-AF patients after valve surgery

No benefit in terms of prevention of ischemic stroke, transient ischemic attack and cardiovascular mortality after 1 year was observed when surgical left atrial appendage occlusion was performed in high-risk non-atrial fibrillation patients after valvular surgery, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

3 Sep 2025

Intravenous cangrelor provides rapid platelet inhibition in cardiogenic shock

Compared with crushed ticagrelor, intravenous cangrelor provided immediate, effective platelet inhibition, with no increase in major bleeding and lower mortality rates in patients with acute myocardial infarction and cardiogenic shock, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

3 Sep 2025

Early aspirin discontinuation safe after complete revascularization in acute MI

Among low-risk patients with acute MI who underwent early complete revascularization and received one month of dual antiplatelet therapy (DAPT), P2Y12 inhibitor monotherapy was noninferior to continued DAPT for adverse cardiovascular and cerebrovascular events, while reducing bleeding risk.

3 Sep 2025

Study links hysterectomy and bilateral oophorectomy to higher stroke risk

Given the seriousness and increased frequency of strokes, many studies have been conducted to assess the relationship between hysterectomy and/or bilateral oophorectomy and the risk of stroke with varying results.

3 Sep 2025

Cardiovascular screening in men aged 60 to 64 years does not reduce all-cause mortality

An invitation to attend a comprehensive screening examination for the early signs of cardiovascular disease (CVD) did not reduce all-cause death among men aged 60 to 64 years, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

2 Sep 2025

Artificial intelligence offers individualized anticoagulation decisions for atrial fibrillation

Mount Sinai researchers developed an AI model to make individualized treatment recommendations for atrial fibrillation (AF) patients-helping clinicians accurately decide whether or not to treat them with anticoagulants (blood thinner medications) to prevent stroke, which is currently the standard treatment course in this patient population.

1 Sep 2025

Dual antiplatelet therapy after heart bypass surgery offers no added benefit over aspirin alone

Dual antiplatelet therapy after heart bypass surgery is not more effective than aspirin alone - and it increases the risk of excessive bleeding. This has now been shown in a study of 2,201 patients at 22 Nordic heart surgery units.

1 Sep 2025

Select groups of myocardial infarction patients benefit from Helicobacter pylori screening

Not all acute myocardial infarction patients should be offered routine screening for the stomach ulcer bacterium Helicobacter pylori.

1 Sep 2025

Shorter dual antiplatelet therapy may offer safety benefits in myocardial infarction patients

Three months of dual antiplatelet therapy (DAPT) was associated with signals suggesting improved survival and lower bleeding risk than 12 months of DAPT, in a real-world all-comer population of patients with myocardial infarction (MI), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Adding aspirin raises cardiovascular events in high-risk CCS patients on anticoagulants

Adding aspirin increased the risk of cardiovascular events, death and major bleeding in high-risk patients with chronic coronary syndrome (CCS) who had prior stenting and were receiving long-term chronic oral anticoagulation (OAC), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Bleeding News and Research

Waning Japanese encephalitis immunity linked to more severe dengue illness

Subcutaneous amivantamab plus lazertinib yields high response in EGFR-mutant lung cancer

Global climate warming fuels rising dengue burden across Asia and the Americas

What diet pattern worsens inflammatory bowel disease?

Dengue infection leaves lasting genetic imprint on immunity

Aspirin therapy does not help people suffering from chronic rhinosinusitis with nasal polyps

No advantage found in modulating antiplatelet therapy intensity after complex stenting

Trial compares the use of blood thinners after stenting in patients with acute coronary syndromes

Dual antiplatelet therapy shows no benefit over aspirin after CABG in patients with acute coronary syndrome

Stopping oral anticoagulation reduces risk after successful atrial fibrillation ablation

No clear benefit from surgical left atrial appendage occlusion in non-AF patients after valve surgery

Intravenous cangrelor provides rapid platelet inhibition in cardiogenic shock

Early aspirin discontinuation safe after complete revascularization in acute MI

Study links hysterectomy and bilateral oophorectomy to higher stroke risk

Cardiovascular screening in men aged 60 to 64 years does not reduce all-cause mortality

Artificial intelligence offers individualized anticoagulation decisions for atrial fibrillation

Dual antiplatelet therapy after heart bypass surgery offers no added benefit over aspirin alone

Select groups of myocardial infarction patients benefit from Helicobacter pylori screening

Shorter dual antiplatelet therapy may offer safety benefits in myocardial infarction patients

Adding aspirin raises cardiovascular events in high-risk CCS patients on anticoagulants

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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