Cell Metabolism News and Research

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Is there a right time for eating?

In a recent study published in the journal Cell Metabolism, researchers assessed how calorie or energy intake (EI) time influences calorie distribution and all energy expenditure (EE) components, which, in turn, impact energy balance and weight loss in healthy obese people.

12 Sep 2022

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

There's the old saying in dieting that one must "breakfast like a king, lunch like a prince, and dine like a pauper," based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently and quickly.

12 Sep 2022

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

The immune system is equipped to respond not just to external invaders - think viruses, bacteria, and parasites - but also to internal threats, namely, cancer. Yet, frequently, malignancies overcome the immune system's defenses and evade detection.

12 Sep 2022

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Immune cells preferentially use cellular waste products to power their function

The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function - including some long thought to be cellular waste products.

17 Aug 2022

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Liver cancer's rapid growth leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.

3 Aug 2022

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

An article published in the journal Nature Communications describes a specific metabolic adaptation in some patients with acute myeloid leukemia affected by tandem mutations in the FLT3 gene.

13 Jul 2022

The smell and sight of a meal stimulate short-lived inflammatory response in the brain

Even before carbohydrates reach the bloodstream, the very sight and smell of a meal trigger the release of insulin.

30 Jun 2022

Drug combinations may help to slow the progression of diabetic kidney disease

A mouse study led by Washington University School of Medicine in St. Louis suggests that combining SGLT2 inhibitors — a newer class of diabetes medications that lowers blood sugar — with older diabetes drugs may help to slow the progression of diabetic kidney disease.

15 Jun 2022

Scientists find new link between high-fat, high-fructose diets and Type 2 diabetes mellitus

Those who are habitually inclined to consume burgers, fries and soda may think twice about their dietary choices following scientists' latest findings about high-fat, high-fructose diets.

10 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Ketogenic diet promotes muscle stem cell resilience but slows injury repair in mice

Fasting sends muscle stem cells into a deep resting state that slows muscle repair but also makes them more resistant to stress, according to a Stanford Medicine study of laboratory mice.

7 Jun 2022

Etiologies of liver cancer are changing and the prognosis is mixed, study says

The primary causes of liver cancer are well known: viral (hepatitis B and C), alcohol and non-alcoholic steatohepatitis (NASH), a condition in which fat builds up in the liver, resulting in chronic inflammation and damage.

7 Jun 2022

Why do diabetic patients have more severe SARS-CoV-2 infections?

A recent study published in the journal Cell Metabolism illustrated the function of angiotensin-converting enzyme 2 (ACE2) in renal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among diabetic patients.

16 May 2022

Changes in gut microbiome impact depression

Over the last five years, the effects of the gut microbiome on depression have gained scientific attention, resulting in a significant increase in research papers.

8 May 2022

SARS-CoV-2 develops partial resistance to the antiviral drug remdesivir in cell culture

The virus that causes COVID-19 can develop partial resistance to the antiviral drug remdesivir during infection of cultured cells in the laboratory by more than one mechanism.

5 May 2022

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

Elevated levels of an enzyme called PHGDH in the blood of older adults could be an early warning sign of Alzheimer's disease, and a study led by the University of California San Diego provides new evidence to support this claim.

4 May 2022

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

A new study addresses the relationship between SARS-CoV-2 to the metabolism of one-carbon molecules in the host, suggesting new therapeutic pathways.

13 Apr 2022

Researchers make progress to develop a drug for treating metabolic syndrome

Metabolic syndrome increases a person's risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar.

11 Apr 2022

People who consume sugar for extended periods have increased risk of autoimmune disease

People who consume sugar and other carbohydrates in excess over a long period of time have an increased risk of developing an autoimmune disease.

23 Mar 2022

Cell Metabolism News and Research

Is there a right time for eating?

Morning-loaded and evening-loaded diets produce similar weight loss, with no energy metabolism differences

Tumor-derived factors stimulate effector trogocytosis and inhibit CAR T cells

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Immune cells preferentially use cellular waste products to power their function

Study pinpoints a three-pronged approach that makes liver cancer cells stop growing

Study reveals a specific metabolic adaptation in some patients with acute myeloid leukemia

The smell and sight of a meal stimulate short-lived inflammatory response in the brain

Drug combinations may help to slow the progression of diabetic kidney disease

Scientists find new link between high-fat, high-fructose diets and Type 2 diabetes mellitus

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Ketogenic diet promotes muscle stem cell resilience but slows injury repair in mice

Etiologies of liver cancer are changing and the prognosis is mixed, study says

Why do diabetic patients have more severe SARS-CoV-2 infections?

Changes in gut microbiome impact depression

SARS-CoV-2 develops partial resistance to the antiviral drug remdesivir in cell culture

Elevated levels of PHGDH enzyme associated with Alzheimer’s disease pathology

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

Researchers make progress to develop a drug for treating metabolic syndrome

People who consume sugar for extended periods have increased risk of autoimmune disease

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