Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Scientists uncover excessive maturation and aging in the hippocampus

In a groundbreaking study, researchers at Fujita Health University and the Tokyo Metropolitan Institute of Medical Science have uncovered a previously overlooked form of brain abnormality linked to anxiety: excessive maturation and aging in the hippocampus, a state they term "hyper-maturity."

27 Oct 2025

New discovery reshapes understanding of how brain inflammation arises in Alzheimer's disease

Researchers at the University of California, Irvine, have uncovered an unexpected molecular partnership that reshapes scientists' understanding of how brain inflammation arises in Alzheimer's disease.

23 Oct 2025

Les Turner Symposium on ALS brings researchers and clinicians to discuss new research findings

The 15th annual Les Turner Symposium on ALS will be held on Monday, Nov. 3, 2025 in Chicago. Hosted by the Les Turner ALS Foundation and the Les Turner ALS Center at Northwestern Medicine, this event will gather leading ALS researchers and clinicians to discuss the latest research and perspectives on the disease.

23 Oct 2025

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson's disease show significantly less brain atrophy—decreased cortical thickness in the brain—than men, despite similar clinical severity.

21 Oct 2025

Study reveals protein plaques in neurodegeneration function as enzymes, breaking down ATP

A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can actively drain energy from brain cells.

21 Oct 2025

Heavy drinking fuels Alzheimer’s disease by igniting brain inflammation and protein damage

Chronic alcohol use accelerates Alzheimer’s disease (AD) progression by intensifying oxidative stress, neuroinflammation, and amyloid-tau pathology through shared molecular pathways. The review highlights emerging therapies, targeting TLR4, GSK-3β, and metabolic dysfunction, that may mitigate alcohol-induced neurodegeneration.

20 Oct 2025

Post-COVID smell loss linked to brain changes in key olfactory regions

Findings indicate significant brain changes in COVID-19 patients with smell loss, suggesting links to emotional well-being and olfactory processing.

17 Oct 2025

Blocking key protein restores healthy lung function and reduces fibrosis in mice

Pulmonary fibrosis is a deadly disease in which the lungs become thickened and scarred, gradually losing their ability to deliver oxygen to the body.

16 Oct 2025

Digital test plus blood biomarker boosts accuracy of Alzheimer’s diagnosis in primary care

A Swedish-led study validated a self-administered digital cognitive test (BioCog) in primary care, showing it can accurately detect objective cognitive impairment before blood biomarkers are applied. When paired with a targeted amyloid blood test, this stepwise pathway outperformed standard assessments for diagnosing clinical Alzheimer’s disease.

12 Oct 2025

Discovery of unique brain cells sheds light on progressive multiple sclerosis

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the disease.

10 Oct 2025

Obesity-linked fat vesicles accelerate amyloid aggregation in Alzheimer’s disease

Researchers discuss the role of extracellular vesicles as a potential link between obesity and Alzheimer’s disease.

9 Oct 2025

New drug candidates show promise for restoring myelin in MS

Multiple sclerosis, or MS, is a chronic autoimmune disease affecting more than 2.9 million people worldwide.

8 Oct 2025

Research explores how blood vessels guide brain development

Blood vessels are more than just pathways for oxygen and nutrients; they also host communicative processes that guide brain development and sustain its function.

8 Oct 2025

Researchers design intrinsically disordered proteins with tailored properties

In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with specific functions, from antibodies to blood clotting agents, by using computers to accurately predict the 3D structure of any given amino acid sequence.

7 Oct 2025

Scientists discover new protein family regulating motility and DNA uptake

Bioengineers at the University of California San Diego have developed a powerful new technology that can map the entire network of RNA-protein interactions inside human cells - an achievement that could offer new strategies for treating diseases ranging from cancer to Alzheimer's.

3 Oct 2025

Thermo Fisher Scientific expands neurodegeneration research capabilities with launch of Olink® Target 48 Neurodegeneration panel

Thermo Fisher Scientific Inc., the world leader in serving science, today announced the launch of the Olink® Target 48 Neurodegeneration panel, a high-performance, targeted proteomics immunoassay panel developed to accelerate discoveries in neurodegenerative disease research.

From Olink®- Part of Thermo Fisher Scientific 3 Oct 2025

New TOR inhibitor rapalink-1 prolongs chronological lifespan in fission yeast

Researchers from Queen Mary University of London's School of Biological and Behavioural Sciences, using the simple fission yeast as a model, have shown that new TOR inhibitor rapalink-1 prolongs chronological lifespan.

29 Sep 2025

Cannabidiol shows promise for obesity and metabolic syndrome

Cannabidiol (CBD) shows promise in regulating appetite, glucose and lipid metabolism, and inflammation in preclinical models of obesity and metabolic syndrome. However, human evidence is still limited, highlighting the need for rigorous trials before clinical use.

29 Sep 2025

Can roselle help fight inflammation? New review suggests strong potential

A new review highlights the anti-inflammatory potential of Hibiscus sabdariffa (roselle), synthesizing evidence from 25 studies published between 2019 and 2024. Most findings are from preclinical models, but they point to promising roles in cardiovascular, metabolic, neuroprotective, and anticancer health.

28 Sep 2025

Cumulative social advantage linked to slower biological aging and lower inflammation

The cumulative effect of social advantages across a lifetime – from parental warmth in childhood to friendship, community engagement and religious support in adulthood – may slow the biological processes of aging.

26 Sep 2025