Central Nervous System News and Research

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Novoron Bioscience receives NIH grant to study novel therapeutic approach for multiple sclerosis

Novoron Bioscience, Inc., a private biotech company dedicated to developing new therapeutics for disorders of the central nervous system, today announced that the company has been awarded a National Institutes of Health grant under the Small Business Innovation Research (SBIR) Program.

22 Dec 2015

Alexza reports interim results from AZ-002 Phase 2a study in epilepsy patients

Alexza Pharmaceuticals, Inc. today announced interim results of its Phase 2a study of AZ-002 (Staccato alprazolam) in epilepsy patients. AZ-002 produced a dose-related decrease in mean Standardized Photosensivity Range (SPR), the primary endpoint in the study.

21 Dec 2015

Aquinnah secures $5 million private equity investment from Takeda

Aquinnah Pharmaceuticals announced today that it has received a $5 Million investment from Takeda Pharmaceutical Company, Limited, in it's first private equity financing. The company has assembled a world-class team of drug developers and an exceptional Scientific Advisory Board in the fields of Amyotrophic Lateral Sclerosis (ALS), protein and RNA regulation, and neurodegenerative diseases.

21 Dec 2015

Targeted alpha therapy has potential to reduce HIV-infected cells from central nervous system

Targeted alpha therapy has the potential to selectively eliminate HIV infected cells from the central nervous system, according to a recent study co-authored by the JRC. The study shows that a specific human antibody labelled with the alpha emitter bismuth-213 can penetrate the blood brain barrier and selectively target and destroy HIV-infected cells while sparing non-infected healthy cells.

21 Dec 2015

Wearable exoskeletons: what interactions are possible? An interview with Dr Juan C. Moreno

Wearable exoskeletons are coming to stay. Technological advancements in embedded computation and wearable mechatronics are enabling the production of new wearable exoskeletons that were not feasible a decade ago

17 Dec 2015

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Early research indicates that the use of tumor-treating fields, a type of electromagnetic field therapy, along with chemotherapy in patients with a brain tumor who had completed standard chemoradiation resulted in prolonged progression-free and overall survival, according to a study in the December 15 issue of JAMA.

16 Dec 2015

Study: Brain cell death may trigger multiple sclerosis

Multiple sclerosis (MS) may be triggered by the death of brain cells that make myelin, the insulation around nerve fibers, according to research on a novel mouse model developed by scientists from the University of Chicago and Northwestern Medicine. The death of these cells initiates an autoimmune response against myelin, the main characteristic of the disease, which leads to MS-like symptoms in mice.

14 Dec 2015

Egalet, Teva sign agreement to commercialize SPRIX Nasal Spray in Israel, Gaza and the West Bank

Egalet Corporation, a fully integrated specialty pharmaceutical company focused on developing, manufacturing and commercializing innovative treatments for pain and other conditions, today announced a collaboration agreement with Teva Pharmaceutical Industries Ltd., a leading global pharmaceutical company.

14 Dec 2015

Report uncovers how Down syndrome hampers nervous system that plays key role in health, longevity

While most Down syndrome research has focused on the brain, a new report by Johns Hopkins University biologists uncovers how the disorder hampers a separate part of the nervous system that plays a key role in health and longevity.

14 Dec 2015

Designing epidemiologic study for multiple sclerosis and other neurologic diseases in Gulf War Vets

The U.S. Department of Veterans Affairs requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to respond to Public Law 110-389 to determine the incidence, prevalence, and risk of developing multiple sclerosis and other neurologic diseases -- including migraines, Parkinson's disease, brain cancers, and central nervous system abnormalities difficult to diagnose precisely -- as a result of service in the 1990-1991 Persian Gulf and post 9/11 Global Operations theaters.

12 Dec 2015

New heart failure drug may increase patients' risk of Alzheimer's disease, macular degeneration

Patients with mild heart failure stand to benefit from a new drug that can halt the progression of their disease and reduce their risk of cardiovascular-related death. But the drug -- a tablet that combines the agents valsartan and sacubitril, sold under the trade name Entresto by drugmaker Novartis -- may be too good to be true, according to Arthur M. Feldman, MD, PhD, Executive Dean of the Lewis Katz School of Medicine at Temple University, Chief Academic Officer of the Temple University Health System, and Laura H. Carnell Professor of Medicine at LKSOM.

10 Dec 2015

Tetra begins human Phase 1 safety trials of BPN14770

Tetra Discovery Partners today announced that the company has initiated human Phase 1 safety trials of its lead compound BPN14770, which Tetra is developing as a potential treatment to both improve memory and slow the progression of Alzheimer's disease.

9 Dec 2015

Surgery and manual physical therapies similarly effective in improving pain for CTS patients

Results of a randomized clinical trial, published in The Journal of Pain, showed that surgery and manual physical therapies were similarly effective in improving pain and function for patients with carpal tunnel syndrome (CTS).

9 Dec 2015

Bionomics plans to launch BNC210 Phase 2 trial for treatment of PTSD

Australian drug development company Bionomics Limited will launch a key Phase 2 trial of its novel anxiety drug BNC210 as a treatment for post-traumatic stress disorder (PTSD), following a US$12 million private placement to US institutional investors.

8 Dec 2015

Children born to mothers with PCOS at increased risk of developing autism

Children born to mothers with polycystic ovarian syndrome, PCOS, are at an increased risk of developing autism spectrum disorders, according to a new epidemiological study from Sweden's Karolinska Institutet. The findings, which are published in the journal Molecular Psychiatry, support the notion that exposure to sex hormones early in life may be important for the development of autism in both sexes.

8 Dec 2015

Existing compound offers hope for slowing Huntington's disease progression

Currently, there is no treatment to halt the progression of Huntington's disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.

8 Dec 2015

Pediatric chemotherapy regimen improves outcomes in young adults with ALL

Using a pediatric chemotherapy regimen to treat young adults with acute lymphoblastic leukemia (ALL) significantly improved their outcomes compared to what has historically been achieved with 'adult' treatment protocols, report Dana-Farber Cancer Institute scientists.

8 Dec 2015

Taking estriol along with conventional medications helps RRMS patients avoid relapses

Taking the pregnancy hormone estriol along with their conventional medications helped patients with relapsing-remitting multiple sclerosis (RRMS) avoid relapses, according to results of a Phase II randomized, placebo-controlled study led by UCLA researchers.

1 Dec 2015

Medical professionals compare different treatment methods for Neuromyelitis optica

In the course of a study conducted throughout Germany, medical professionals have compared different treatment methods for Neuromyelitis optica, an inflammatory disease of the central nervous system. It turned out that the best results were not achieved with conventional steroid therapy. Under the auspices of the Ruhr-Universität Bochum and the Hannover Medical School, the team published their findings in the journal Annals of Neurology.

30 Nov 2015

Rare variants linked with Parkinson’s disease

Researchers using exome sequencing in families with Parkinson’s disease have identified two genes that could be associated with the condition.

27 Nov 2015

Central Nervous System News and Research

Novoron Bioscience receives NIH grant to study novel therapeutic approach for multiple sclerosis

Alexza reports interim results from AZ-002 Phase 2a study in epilepsy patients

Aquinnah secures $5 million private equity investment from Takeda

Targeted alpha therapy has potential to reduce HIV-infected cells from central nervous system

Wearable exoskeletons: what interactions are possible? An interview with Dr Juan C. Moreno

Use of tumor-treating fields along with chemotherapy improves survival in patients with brain tumor

Study: Brain cell death may trigger multiple sclerosis

Egalet, Teva sign agreement to commercialize SPRIX Nasal Spray in Israel, Gaza and the West Bank

Report uncovers how Down syndrome hampers nervous system that plays key role in health, longevity

Designing epidemiologic study for multiple sclerosis and other neurologic diseases in Gulf War Vets

New heart failure drug may increase patients' risk of Alzheimer's disease, macular degeneration

Tetra begins human Phase 1 safety trials of BPN14770

Surgery and manual physical therapies similarly effective in improving pain for CTS patients

Bionomics plans to launch BNC210 Phase 2 trial for treatment of PTSD

Children born to mothers with PCOS at increased risk of developing autism

Existing compound offers hope for slowing Huntington's disease progression

Pediatric chemotherapy regimen improves outcomes in young adults with ALL

Taking estriol along with conventional medications helps RRMS patients avoid relapses

Medical professionals compare different treatment methods for Neuromyelitis optica

Rare variants linked with Parkinson’s disease

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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