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Strong evidence several FDA approved drugs block SARS-CoV-2 in relevant cell-lines and human organoids

Now, a new study describes how compounds that restore the normal transcriptional conditions following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be used to reduce viral load without neutralizing the virus entry into the host cell.

15 Jul 2020

Investigational antidepressant PT150 shows antiviral activity against SARS-CoV-2

In a recent bioRxiv study, an ad hoc multi-institutional research team from the US shows that a novel hormone receptor modulator PT150 has unique and possibly additive antiviral and immunomodulatory effects – highlighting its potential role in the treatment and prophylaxis of coronavirus disease (COVID-19).

14 Jul 2020

Co-twin loss linked to elevated risk of psychiatric disorders

The death of a twin, especially earlier in life, can increase the risk of their surviving twin being diagnosed with a psychiatric disorder, finds a new study published today in eLife.

14 Jul 2020

UMass Amherst chemist and kinesiologist synthesize artificial fuel for muscle

A chemist and kinesiologist got on a bus, but this isn't the set-up to a joke. Instead, kinesiologist and lead author Ned Debold and chemist Dhandapani Venkataraman, "DV," began talking on their bus commute to the University of Massachusetts Amherst and discovered their mutual interest in how energy is converted from one form to another - for Debold, in muscle tissue and for DV, in solar cells.

14 Jul 2020

Cancer drug could help inhibit adenovirus infection

An adenovirus infection can be potentially life-threatening, especially for children after a stem cell transplant.

14 Jul 2020

Compound in pickled capers can directly regulate proteins required for bodily processes

A compound commonly found in pickled capers has been shown to activate proteins required for normal human brain and heart activity, and may even lead to future therapies for the treatment of epilepsy and abnormal heart rhythms.

14 Jul 2020

Researchers uncover new mechanism for designing antiviral drugs for dengue virus

A multidisciplinary team from The University of Texas Medical Branch at Galveston has uncovered a new mechanism for designing antiviral drugs for dengue virus. The study is currently available in Proceedings of the National Academy of Sciences.

14 Jul 2020

Study identifies three novel broad-spectrum SARS-CoV-2 cell entry inhibitors

Researchers from the National Institutes of Health (NIH) and Cornell University in the U.S. just described several new inhibitors of human coronavirus spike proteins by screening a library of approved drugs with SARS-S and MERS-S pseudotyped particle entry assays. Their exciting findings are currently available on the bioRxiv preprint server.

13 Jul 2020

New chemical could potentially lead to a cure for neglected tropical diseases

Scientists say they are a step closer to developing a drug to kill the trypanosome parasite that causes human African trypanosomiasis, otherwise known as sleeping sickness, paving the way for a potential cure.

13 Jul 2020

Study shows safety and effectiveness of PET radiotracer in imaging glioblastomas

A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting has demonstrated the safety, favorable pharmacokinetic and dosimetry profile of 64Cu-EBRGD, a new, relatively long-lived PET tracer, in patients with glioblastomas.

13 Jul 2020

Novel drug could enable the immune system to attack ovarian cancer

A drug known as SP-2577 could help enable the body's own immune system to attack ovarian cancer, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope.

13 Jul 2020

Newly discovered chemical compound shows potential to become treatment for brain disorders

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism.

11 Jul 2020

Study explains why humans taste some flavors more quickly than others

A new study might explain why humans register some tastes more quickly than others, potentially due to each flavor's molecular size.

9 Jul 2020

New research can help overcome challenges in diabetes research

Scientists focused on finding better treatments or cures for types 1 or 2 diabetes are painfully aware of current limitations, including having to use animal tissue in studies that often don't translate to human trials.

9 Jul 2020

Scientists identify how good gut bacteria can help reduce heart disease risk

Scientists have discovered that one of the good bacteria found in the human gut has a benefit that has remained unrecognized until now: the potential to reduce the risk for heart disease.

8 Jul 2020

Small molecule drugs binding Mac1 domain of SARS-CoV-2

Now, an intriguing new study out of the University of Wisconsin-Milwaukee reveals that numerous small molecule drugs like the proton pump inhibitors omeprazole and rabeprazole bind the important Mac1 domain on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.

8 Jul 2020