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Precise DNA cleavage using new CRISPR-Cas approach

A team led by investigators at Massachusetts General Hospital (MGH) has overcome a major constraint for cutting and editing DNA by CRISPR-Cas enzymes and other technologies.

11 Oct 2022

$2.5 million CDC contract to fund one of the largest SARS-CoV-2 surveillance programs in the U.S.

A team led by Scripps Research scientists has been awarded a contract by the U.S. Centers for Disease Control & Prevention (CDC) in support of one of the largest SARS-CoV-2 surveillance programs in the United States.

11 Oct 2022

Common diabetes medication identified as a possible treatment for atrial fibrillation

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

11 Oct 2022

Cell-free DNA circulating in the blood may signal early signs of dementia and frailty

In a long-term prospective study of more than 600 older participants, Johns Hopkins Medicine researchers say they have evidence that higher levels of cell-free DNA circulating in the blood may signal increased risk of chronic inflammation associated with early signs of frailty and dementia.

11 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

BNT162b2 COVID-19 booster vaccine induces robust humoral responses independent of the interval between the first two doses

A recent Cell Reports study evaluated humoral responses induced after the second and third doses of the mRNA vaccine.

11 Oct 2022

Study offers a systems biology strategy to facilitate the search for effective COVID-19 drugs

A Cleveland Clinic-led research team used artificial intelligence to map out hundreds of ways that the virus that causes COVID-19 interacts with infected cells.

10 Oct 2022

Self-teaching deep learning algorithm can find similar cases in large pathology image repositories

Rare diseases are often difficult to diagnose and predicting the best course of treatment can be challenging for clinicians.

10 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

NEI researchers create a high-resolution map of retinal cell chromatin contract points

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's nucleus.

7 Oct 2022

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

Researchers demonstrated that the SARS-CoV-2 protein functions as a histone mimic to disrupt the epigenetic regulation of host cells.

7 Oct 2022

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Researchers explored the role of the ORF3c, a SARS-CoV-2 accessory protein not so extensively studied as yet.

7 Oct 2022

Scientists discover a new drug-resistance mechanism in breast cancer

Scientists from Università Cattolica in Rome, together with colleagues from the IIGM Foundation (part of Candiolo Institute at Turin), have discovered a new drug-resistance mechanism in breast cancer that leads to the formation of cancer stem cells, (the cells that feed the tumor and cause relapse and metastasis).

6 Oct 2022

Researchers create a clinical scoring system to predict viable viral shedding after COVID-19 infection

A recent study published in the Journal of Clinical Virology developed an individualized scoring system to predict the shedding of viable SARS-CoV-2 from COVID-19 positive patients, which would help to determine personalized isolation strategies.

6 Oct 2022

Environmental surveillance of SARS-CoV-2 could predict COVID-19 cases

A new study reported that coronavirus disease 2019 (COVID-19) cases could be predicted by environmental surveillance.

6 Oct 2022

Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

In a new study, researchers performed a genomic study of confirmed Monkeypox virus (MPXV) cases diagnosed in Spain between 18 May and 14 July 2022.

4 Oct 2022

Sudden cardiac death risk can be determined by genetic score

A recent study published in the Journal of the American College of Cardiology found that a genome-wide polygenic score for coronary artery disease (GPSCAD) can predict sudden and/or arrhythmic death (SAD) risk in coronary artery disease (CAD) patients without severe systolic dysfunction.

3 Oct 2022

Genomic News and Research

Precise DNA cleavage using new CRISPR-Cas approach

$2.5 million CDC contract to fund one of the largest SARS-CoV-2 surveillance programs in the U.S.

Common diabetes medication identified as a possible treatment for atrial fibrillation

Cell-free DNA circulating in the blood may signal early signs of dementia and frailty

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

BNT162b2 COVID-19 booster vaccine induces robust humoral responses independent of the interval between the first two doses

Study offers a systems biology strategy to facilitate the search for effective COVID-19 drugs

Self-teaching deep learning algorithm can find similar cases in large pathology image repositories

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

NEI researchers create a high-resolution map of retinal cell chromatin contract points

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

The effect of ORF3c, a SARS-CoV-2 accessory protein, on cellular innate immune responses, autophagy, and lung cell mitochondrial metabolism

Scientists discover a new drug-resistance mechanism in breast cancer

Researchers create a clinical scoring system to predict viable viral shedding after COVID-19 infection

Environmental surveillance of SARS-CoV-2 could predict COVID-19 cases

Study attributes increased transmissibility of Monkeypox Clade IIb to genomic accordions

Sudden cardiac death risk can be determined by genetic score

Fungal involvement in tumors may drive worse cancer outcomes

A case for updating COVID vaccines with beta variant spike sequences

Is it safe to breastfeed after the COVID-19 mRNA vaccination?

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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