Membrane News and Research

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How do glycans affect SARS-CoV-2 spike protein openings?

In a paper recently uploaded to the bioRxiv* preprint server, the role of glycan coating on the SARS-CoV-2 spike protein is further investigated by molecular dynamics simulations of the glycosylated and non-glycosylated protein, identifying several key glycans that play a role in stabilizing and protecting the RBD, and also encourage bonding with the ACE2 receptor.

18 Aug 2021

Fetal membranes can heal after injury, study shows

Scientists from Queen Mary University of London and UCL have shown that fetal membranes are able to heal after injury in a new study.

18 Aug 2021

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Blue light is illuminating new understanding of a key signaling pathway in embryo development, tissue maintenance and cancer genesis.

17 Aug 2021

Mutated enzyme impairs communication between neurons and causes motor defects in SCA34 model

In one type of a rare, inherited genetic disorder that affects control of body movement, scientists have found a mutation in an enzyme that impairs communication between neurons and what should be the inherent ability to pick up our pace when we need to run, instead of walk, across the street.

17 Aug 2021

Biotium releases new ExoBrite EV Membrane Staining Kits

Biotium, a leading supplier and inventor of fluorescent cellular probes for life science research, announces the release of new ExoBrite™ EV Membrane Staining Kits.

17 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

How delta and kappa variants of SARS-CoV-2 evade the immune system

A new study, available on the bioRxiv* preprint server, describes the neutralizing ability of the monoclonal antibodies against the variants and the difference of the ACE2 binding affinity found in the variants.

17 Aug 2021

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Now, a new study posted to the bioRxiv* preprint server focuses on functional immune memory to SARS-CoV-2, up to nine months in a Southeast Asian cohort, in the absence of re-infection.

16 Aug 2021

Enzyme acts as a sensor to find the hiding spots of viruses

While some types of RNA viruses cloak themselves to hide inside a cell and create copies of themselves, a "detective enzyme" might be attuned to their whereabouts. A slight variation in their genomic code gives some people's cells the capacity to produce this sensor.

14 Aug 2021

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

A new study published in the journal Nature Communications has reported two neutralizing antibodies, namely, nCoVmab1 and nCoVmab2, which are potent against SARS-CoV-2.

13 Aug 2021

Optical nanoscopy reveals how SARS-CoV-2 infection alters human airway cells

How do viruses reorganize host cells with spatial and molecular specificity? Researchers from the Netherlands provided new insights in a recent study posted to the bioRxiv* preprint server, where they use optical nanoscopy to look at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-triggered changes in primary human airway cells.

12 Aug 2021

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Researchers from the University of Southern California, Merck & Co., Skoltech, MIPT, UCLA, and the Université de Sherbrooke have determined the structure of the human leukotriene B4 receptor 1, involved in inflammatory, infectious, allergic, and tumorigenic diseases.

12 Aug 2021

Getting a covid vaccine during pregnancy even more urgent as ICU beds fill up

The Centers for Disease Control and Prevention is doubling down on its recommendation that people who are pregnant get the covid-19 vaccine, in light of new data underscoring its safety and effectiveness throughout pregnancy.

12 Aug 2021

Researchers look into the effects of particle contaminants on mucosal system

Major disruptions to our health and quality of life are front of mind in an era when wildfires, floods, and the ongoing COVID-19 pandemic impact Earth's population daily.

10 Aug 2021

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

Children's Hospital Colorado today announced it has joined the Xplore2/Pivotal trial, and is actively enrolling patients for the first-ever pivotal trial of a synthetic restorative pulmonary valve.

9 Aug 2021

A multi-scale cryo-correlative platform to image SARS-CoV-2 in Vero cells

A new study describes the cytopathic episodes triggered by SARS-CoV-2 with virus replication processes in frozen-hydrated cells.

9 Aug 2021

New biocompatible glue could quickly seal injured tissues and stop bleeding

Inspired by the sticky substance that barnacles use to cling to rocks, MIT engineers have designed a strong, biocompatible glue that can seal injured tissues and stop bleeding.

9 Aug 2021

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

A new study has explored a series of potential flavonoid inhibitors targeting 3CL protease of SARS-CoV.

9 Aug 2021

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

The spike protein comprises of two subunits: S1 subunit having the receptor-binding domain (RBD) that helps it to bind to the angiotensin-converting enzyme 2 (ACE2), which is present on the cell surface of the host, and the S2 subunit that helps in the fusion of the cellular membrane and the viral membrane.

9 Aug 2021

Membrane News and Research

How do glycans affect SARS-CoV-2 spike protein openings?

Fetal membranes can heal after injury, study shows

Designing antimalarials with multiple targeting mechanisms of action

Blue light can activate key signaling pathway that plays role in embryonic development and cancer

Mutated enzyme impairs communication between neurons and causes motor defects in SCA34 model

Biotium releases new ExoBrite EV Membrane Staining Kits

Making the nanobody big again for Cryo-EM

How delta and kappa variants of SARS-CoV-2 evade the immune system

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Enzyme acts as a sensor to find the hiding spots of viruses

Discovery of highly potent neutralizing monoclonal antibodies against SARS-CoV-2

Optical nanoscopy reveals how SARS-CoV-2 infection alters human airway cells

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Getting a covid vaccine during pregnancy even more urgent as ICU beds fill up

Researchers look into the effects of particle contaminants on mucosal system

Children's Hospital Colorado announces participation in pivotal trial of synthetic restorative pulmonary valve

A multi-scale cryo-correlative platform to image SARS-CoV-2 in Vero cells

New biocompatible glue could quickly seal injured tissues and stop bleeding

Flavonoid-based inhibitors targeting SARS-CoV 3CL protease for the treatment of SARS-CoV-2 infection

Research shows how SARS-CoV-2 variants are evolving towards increased furin cleavage efficiency

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