Mouse Model News and Research

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Loss of cells in the brain found to be associated with stuttering

Researchers believe that stuttering - a potentially lifelong and debilitating speech disorder - stems from problems with the circuits in the brain that control speech, but precisely how and where these problems occur is unknown.

19 Aug 2019

Liver dysfunction provokes cerebral molecular disturbances in two weeks

The liver plays a vital role as a filter in the human body. But what happens when it malfunctions? Researchers from the Universities of Geneva and Lausanne, the Vaud University Hospital Centre, the Centre for Biomedical Imaging, the Federal Polytechnic School of Lausanne and the University Hospitals of Geneva, Switzerland, teamed up to perform a detailed analysis of hepatic encephalopathy, a type of brain damage caused by chronic liver disease.

19 Aug 2019

Stress inhibits eating behavior

Many human beings can’t swallow a thing when faced with significant stress, among other strong emotional states. However, scientists don’t know much about how the brain brings about these emotion-related effects on eating behavior.

19 Aug 2019

Researchers discover how stress can decrease the desire to eat

Eating disorder researchers at The University of Texas Health Science Center at Houston (UTHealth) have discovered a neurocircuit in mice that, when activated, increased their stress levels while decreasing their desire to eat. Findings appear in Nature Communications.

18 Aug 2019

Machine learning reveals links between genetic factors and behavior

Researchers have used machine learning to start making links between seemingly instinctive, random behaviors and genetic factors.

15 Aug 2019

Removing single enzyme improves outcomes in mouse model of sepsis

Sepsis occurs when the body goes overboard in its attempt to fight off an infection. Immune cells rush in, overreact and wreak havoc on tissues and organs, often resulting in organ failure and death.

14 Aug 2019

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines.

From Johns Hopkins Medicine 13 Aug 2019

Negative memory hippocampal engrams could underlie cognitive symptoms of depression

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to research in mice published in JNeurosci. Inhibiting these manifestations could be a future treatment route.

From Society for Neuroscience 13 Aug 2019

Longer-lived, but less toxic drug may work better for pancreatic cancer

Unlike many other cancers, most pancreatic tumors are rock hard.

9 Aug 2019

Study shows how cigarette smoke drives tumor aggressiveness in head and neck cancer

Head and neck cancer is the sixth most common cancer in the world. The vast majority of cases are head and neck squamous cell carcinoma, a type of cancer that arises in the outer layer of the skin and mucous membranes of the mouth, nose and throat.

8 Aug 2019

New improved model for cancer wasting syndrome cachexia

A new model of cancer-related cachexia promises to help scientists understand why patients with cancer show severe wasting, which in turn may drive the development of better therapies.

7 Aug 2019

New mouse model could lead to a better understanding of cachexia syndrome

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidences in pancreatic cancer patients.

6 Aug 2019

New nanovaccine for deadly skin cancer

Tel Aviv scientists have published their version of a vaccine against the deadly skin cancer malignant melanoma, which arises from the pigment producing cells of the skin. This is the most feared form of skin cancer, with a high tendency to metastasize to distant parts of the body, including the brain.

6 Aug 2019

Whole body vibration helps reduce inflammation, thanks to the gut microbiome

Whole body vibration appears to improve many symptoms of type II diabetes mellitus, wherein glucose and destructive inflammation shoots up. The procedure helps the body use glucose as an energy source, and at the same time, modify the microbiome to fight inflammation, a new study says.

6 Aug 2019

Tel Aviv researchers develop a nano-vaccine for the most aggressive skin cancer

Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer.

5 Aug 2019

Whole body vibration adjusts the microbiome and immune cells to deter inflammation in diabetes

In the face of diabetes, a common condition in which glucose and levels of destructive inflammation soar, whole body vibration appears to improve how well our body uses glucose as an energy source and adjust our microbiome and immune cells to deter inflammation, investigators report.

5 Aug 2019

Discovery of distinct lung cancer pathways could help future patients

Known for its poor prognosis, lung adenocarcinoma is the most common type of lung cancer, responsible for about 4 of 10 diagnoses, according to the National Cancer Institute.

2 Aug 2019

Mice brain study reveals secrets about Alzheimer’s

Researchers from University of California, Irvine have found the key responses of brain cells to Alzheimer’s disease (AD) and say that this could help them understand the chronic debilitating and progressive neurodegenerative disease better in future.

1 Aug 2019

Harnessing anti-inflammatory function of macrophages holds great potential for treating diseases

Researchers at the University of Illinois at Chicago have identified a molecular switch that causes immune cells called macrophages to clean up cellular debris caused by infections instead of contributing to inflammation and tissue injury.

31 Jul 2019

Researchers unlock the key to clearly identifying diseased beta cells in type 2 diabetes

Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes. This discovery has both research and therapeutic implications.

30 Jul 2019