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Scientists discover pathway that prevents buildup of Alzheimer's protein

St. Jude Children's Research Hospital scientists have discovered a pathway that functions like a car wash to prevent the buildup of a toxic protein associated with Alzheimer's disease. The report appeared online today in the journal Cell.

28 Jun 2019

Researchers study link between childhood viral infections and cerebral autoimmune disease

Although the exact causes of multiple sclerosis still remain unknown, it is assumed that the disease is triggered by a combination of genetic and environmental risk factors.

26 Jun 2019

Scientists use advanced imaging to track brain tumor 'turncoats'

Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny.

26 Jun 2019

New promising approach repairs system of blood vessels following stroke

Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions.

25 Jun 2019

Scientists discover new drug target for chemically induced Parkinson's disease

More than three decades ago, scientists discovered that a chemical found in a synthetic opioid, MPTP, induced the onset of a form of Parkinson's disease.

23 Jun 2019

Researchers develop model of intestinal infection that could advance vaccine development

The intestinal parasite Cryptosporidium, which causes a diarrheal disease, is very good at infecting humans. It's the leading cause of waterborne disease from recreational waters in the United States.

21 Jun 2019

Highlights and key takeaways from the 2019 Boston Bacterial Meeting (BBM)

Missed out on the 2019 Boston Bacterial Meeting (BBM)? Read our round-up of the key takeaways, areas of discussion, speakers and more.

19 Jun 2019

Complement system shown to remove dead cells in retinitis pigmentosa, contradicting previous research

Researchers have found that the complement system seems to protect against retinal degeneration in retinitis pigmentosa.

18 Jun 2019

Breastmilk antibody necessary to prevent necrotizing enterocolitis in preterm infants

A new study from the University of Pittsburgh and UPMC Children's Hospital of Pittsburgh finds that an antibody in breastmilk is necessary to prevent necrotizing enterocolitis (NEC)- an often deadly bacterial disease of the intestine-in preterm infants.

17 Jun 2019

Augusta vision scientist receives grant to learn more about keratoconus’ causes and treatments

It's an eye condition where genetics and environmental factors like ultraviolet light and vigorous eye rubbing conspire to make the usual curvature of the cornea more pointy, leaving us with double vision and nearsighted.

17 Jun 2019

New discovery could improve therapies for Duchenne muscular dystrophy

A new multi-institution study spearheaded by researchers at Florida State University and the University of California, Los Angeles suggests a tiny protein could play a major role in combating heart failure related to Duchenne muscular dystrophy (DMD), the most common lethal genetic disorder among children.

16 Jun 2019

Polycomb protein EED plays a complex role in brain development

The dentate gyrus (DG) is the input region of the hippocampus and plays an important role in learning and memory.

13 Jun 2019

Study shows how fine motor tasks promote plastic reorganization of certain brain region

When we train the reaching for and grasping of objects, we also train our brain. In other words, this action brings about changes in the connections of a certain neuronal population in the red nucleus, a region of the midbrain.

12 Jun 2019

Researchers develop new gene-targeted approach to study chronic wasting disease in mice

Infectious proteins called prions cause a group of related, fatal and incurable neurodegenerative disorders, including bovine spongiform encephalopathy or Mad Cow disease and Creutzfeldt-Jakob disease, both of which affect humans.

12 Jun 2019

UIC researchers describe role of unique pressure-sensing protein in lung edema

Researchers at the University of Illinois at Chicago describe for the first time the role of a unique, pressure-sensing protein in the development of lung edema -- a condition in which chronic high vascular pressure in the lungs causes fluid from the bloodstream to enter the air spaces of the lungs.

11 Jun 2019

Researchers succeed in conquering chronic infection with hepatitis B virus

Researchers at Helmholtz Zentrum München and the Technical University of Munich, working in collaboration with researchers at the University Medical Center Hamburg-Eppendorf and the University Hospital Heidelberg, have for the first time succeeded in conquering a chronic infection with the hepatitis B virus in a mouse model.

11 Jun 2019

Study shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cells

Patients with chronic myeloid leukemia can be treated with tyrosine kinase inhibitors. While these effective drugs lead to deep remission and prolonged survival, primitive leukemia stem cells resist elimination during the remission and persist as a major barrier to cure.

11 Jun 2019

Bacteriophage can have a profound impact on the dynamics of gut microbiome, study finds

The gut microbiome is a complex, interconnected ecosystem of species. And, like any ecosystem, some organisms are predators and some are prey.

7 Jun 2019

CAPON protein may facilitate link between two most well-known Alzheimer's culprits

A new protein involved in Alzheimer's disease has been identified by researchers at the RIKEN Center for Brain Science.

7 Jun 2019

Rettsyndrome.org funds research that will benefit boys and girls with MECP2-related disorders

Rettsyndrome.org announced their funding of two new research projects today. Jeannie T. Lee, MD, Ph.D. of Massachusetts General Hospital is awarded a two-year ANGEL Grant for $600,000 to focus on reactivating the silent X chromosome for Rett syndrome and Davut Pehlivan, MDof Baylor College of Medicine is awarded a two-year Mentored Clinical Fellowship for $250,000 to study MECP2 Duplication syndrome.

6 Jun 2019

Mouse Model News and Research

Scientists discover pathway that prevents buildup of Alzheimer's protein

Researchers study link between childhood viral infections and cerebral autoimmune disease

Scientists use advanced imaging to track brain tumor 'turncoats'

New promising approach repairs system of blood vessels following stroke

Scientists discover new drug target for chemically induced Parkinson's disease

Researchers develop model of intestinal infection that could advance vaccine development

Highlights and key takeaways from the 2019 Boston Bacterial Meeting (BBM)

Complement system shown to remove dead cells in retinitis pigmentosa, contradicting previous research

Breastmilk antibody necessary to prevent necrotizing enterocolitis in preterm infants

Augusta vision scientist receives grant to learn more about keratoconus’ causes and treatments

New discovery could improve therapies for Duchenne muscular dystrophy

Polycomb protein EED plays a complex role in brain development

Study shows how fine motor tasks promote plastic reorganization of certain brain region

Researchers develop new gene-targeted approach to study chronic wasting disease in mice

UIC researchers describe role of unique pressure-sensing protein in lung edema

Researchers succeed in conquering chronic infection with hepatitis B virus

Study shows how SIRT1 plays key role in maintaining the regenerative potential of leukemic stem cells

Bacteriophage can have a profound impact on the dynamics of gut microbiome, study finds

CAPON protein may facilitate link between two most well-known Alzheimer's culprits

Rettsyndrome.org funds research that will benefit boys and girls with MECP2-related disorders

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