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Research shows basophils are key players in lung development

Lungs are vital organs required for the uptake of oxygen in exchange for carbon dioxide. However, the enormous complexity of the respiratory organ is often underestimated and deserves a closer look: A broad range of specialized cells work closely together to ensure the proper functioning of the lung and provide the vital gas exchange.

12 Oct 2018

Cornell dots equipped with antibody fragments offer a new cancer weapon

Antibody-based imaging of a particularly aggressive form of breast cancer is undergoing clinical trials worldwide, but the path from trial to application is being hampered by a major obstacle: safety.

12 Oct 2018

Study reveals factors linked to the development of Crohn's disease

How cells talk to each other, and what they say, has long held fascination for Seema Khurana, professor of biology and biochemistry.

5 Oct 2018

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today updated positive results from its Phase 1/2 clinical study of lumasiran, an investigational, subcutaneously administered RNAi therapeutic targeting glycolate oxidase for the treatment of primary hyperoxaluria type 1.

4 Oct 2018

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that it has submitted a Clinical Trial Authorization application to the Medicines and Healthcare products Regulatory Agency to initiate a Phase 1/2 study of ALN-AAT02, an investigational RNAi therapeutic targeting alpha-1 antitrypsin for the treatment of AAT deficiency-associated liver disease.

3 Oct 2018

Study highlights need for population-specific precision medicine programs in Latin America

Drug safety and effectiveness vary greatly among populations worldwide. Genetics is one of the factors that contribute to variability in drug response.

3 Oct 2018

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today further progress on the Company's platform efforts in extrahepatic delivery of novel siRNA conjugates, including central nervous system (CNS) and ocular delivery in rat and non-human primates (NHPs).

3 Oct 2018

Scientists investigate effect of flu-causing virus on three lung-derived cell lines

Perhaps inspired by the annual 3 to 5 million cases of severe influenza worldwide, the Guinness World Record organization is advertising for individuals or organizations to attempt a record for the most people getting a flu awareness lesson at once.

29 Sep 2018

New Vatican-based white paper describes expert-led effort to improve global palliative care

A new white paper, developed by the Vatican-based Pontifical Academy for Life, describes the broad-based, expert-led effort to develop recommendations for improving global palliative care.

28 Sep 2018

Rochester and Minnesota team receives grant to create center for child maltreatment studies

The University of Rochester's Mt. Hope Family Center, in conjunction with the University of Minnesota's Institute for Translational Research in Children's Mental Health, has received a multi-million-dollar grant to create a national center for child maltreatment studies, becoming one of only three academic institutional partnerships in the United States to receive this prestigious award from the National Institutes of Health.

28 Sep 2018

Dennis and Mireille Gillings Foundation donates £600,000 for pilot FLIER program

The Academy of Medical Sciences is delighted to announce a pledge of £600,000 from the Dennis and Mireille Gillings Foundation towards a pilot programme to develop two cohorts of innovative new leaders in medical science.

28 Sep 2018

UCI researchers receive $3.4 million grant to study new class of cancer killing immunotherapeutics

UCI School of Medicine researchers have been awarded a $3.4 million grant by the National Cancer Institute as part of the Beau Biden Cancer Moonshot initiative.

27 Sep 2018

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today positive topline results from the interim analysis of the ENVISION Phase 3 Study of givosiran, an investigational RNAi therapeutic targeting aminolevulinic acid synthase 1 for the treatment of acute hepatic porphyria.

27 Sep 2018

IU-Regenstrief partnership receives 1 of 11 grants for next generation of learning health system researchers

A partnership between Indiana University School of Medicine and the Regenstrief Institute is one of 11 U.S. recipients selected to train researchers to conduct patient-centered outcomes research within learning health systems.

27 Sep 2018

African swine fever virus does not pose risk to humans

The ASF pathogen is a virus which infects domestic pigs and wild boar and which leads to a severe, often lethal, disease in these animals. It is transferred via direct contact or with excretions from infected animals, or through ticks.

26 Sep 2018

PCORI, AHRQ announce awards to support patient-centered outcomes research in learning health systems

The Agency for Healthcare Research and Quality (AHRQ) and the Patient-Centered Outcomes Research Institute (PCORI) today announced $40 million in awards over five years to 11 institutions to support the training of researchers to conduct patient-centered outcomes research (PCOR) within learning health systems (LHS).

26 Sep 2018

Hybrid theranostic complex shows high therapeutic efficacy against tumor cells

Emerging cancer nanotechnology enables target-delivery of substantial payloads of drugs to cancer sites with concomitant reduction of side-effects due to the lesser accumulation in the critical organs.

25 Sep 2018

Human-oriented perspective needed to better understand Parkinson's disease

Analysis published in Drug Discovery Today reveals the gap between animal models of Parkinson's disease and our understanding of the neurodegenerative processes underlying the disease, and calls for the implementation of modern, human biology-based technologies to better understand pathological processes and improve treatment outcome.

25 Sep 2018

Scientist intends to fight pathogenic bacteria with viruses

Dr. Li Deng of Helmholtz Zentrum München has been awarded a Starting Grant of the European Research Council. The scientist intends to tackle antimicrobial resistance by fighting bacteria with their natural enemies - the viruses. The grant is endowed with nearly 1.5 million euros for five years.

21 Sep 2018

Scientists achieve breakthrough in accelerated diagnosis of multi-resistant hospital pathogens

A team of researchers at the University of Cologne's Faculty of Medicine and the German Center for Infection Research has achieved a scientific breakthrough in the accelerated diagnosis of multi-resistant hospital pathogens.

20 Sep 2018

Translation News and Research

Research shows basophils are key players in lung development

Cornell dots equipped with antibody fragments offer a new cancer weapon

Study reveals factors linked to the development of Crohn's disease

Alnylam announces positive results from Phase 1/2 study of lumasiran for treating primary hyperoxaluria-1

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Study highlights need for population-specific precision medicine programs in Latin America

Alnylam reports further progress on broadening the therapeutic potential of RNAi

Scientists investigate effect of flu-causing virus on three lung-derived cell lines

New Vatican-based white paper describes expert-led effort to improve global palliative care

Rochester and Minnesota team receives grant to create center for child maltreatment studies

Dennis and Mireille Gillings Foundation donates £600,000 for pilot FLIER program

UCI researchers receive $3.4 million grant to study new class of cancer killing immunotherapeutics

Alnylam announces positive results from Phase 3 Study of givosiran for treating acute hepatic porphyria

IU-Regenstrief partnership receives 1 of 11 grants for next generation of learning health system researchers

African swine fever virus does not pose risk to humans

PCORI, AHRQ announce awards to support patient-centered outcomes research in learning health systems

Hybrid theranostic complex shows high therapeutic efficacy against tumor cells

Human-oriented perspective needed to better understand Parkinson's disease

Scientist intends to fight pathogenic bacteria with viruses

Scientists achieve breakthrough in accelerated diagnosis of multi-resistant hospital pathogens

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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