Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Dimeric IgA antibodies help identify recent SARS-CoV-2 infection

A fascinating new study, released as a preprint on the medRxiv* server, adds a highly appealing tool to the armory of detection techniques for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its validation could allow the early and accurate detection of recent or active infection, which is valuable in tracing contacts and preventing forward transmission of the virus.

5 Jul 2021

EULAR Patient Research Partners join in new research project to advance treatment of psoriatic arthritis

Eleven Patient Research Partners (PRPs) from three organizations (EULAR, GRAPPA-EU, and EUROPSO) participate in the new research project HIPPOCRATES, ensuring the patients' perspective is preserved and prioritized in all research activities to maximize the project's impact.

2 Jul 2021

Researchers highlight easily adoptable methods to improve outcomes for patients with gastroesophageal cancer

Two Roswell Park Comprehensive Cancer Center experts were invited to present new insights on treatment of gastroesophageal cancers during the European Society for Medical Oncology World Congress on Gastrointestinal Cancer 2021.

2 Jul 2021

Salivary markers of oxidative stress during severe COVID-19

An interesting study from researchers at the University of Sharjah, Sharjah, United Arab Emirates, presents evidence that an elevated level of expression of oxidant molecules may be correlated with severe infection and lung injury.

2 Jul 2021

New PET imaging method tracks immunotherapeutic efficacy in mouse models

Several cancer tumors grow through immunosuppression; that is, they manipulate biological systems in their microenvironments and signal to a specific set of immune cells--those that clear out aberrant cells--to stop acting. It is no wonder that immunotherapy designed to re-establish anti-tumor immunity is rapidly becoming the treatment of choice for these cancers.

2 Jul 2021

Discovery of blood biomarker opens new perspectives for dietary prevention of AMD-related risks

Age-related macular degeneration (AMD) is the principal cause of vision loss in industrialised countries, with nearly 20 million people affected in Europe in 2020. Although identified as a risk factor, until now it was impossible to evaluate retinal omega-3 fatty acid deficits.

30 Jun 2021

Researchers identify specific biomarkers for coronary microvascular disease

Although cardiovascular disease is the main cause of illness among women in the U.S., certain conditions such as coronary microvascular disease (CMD) cannot be easily diagnosed. In a new study, researchers at the University of Illinois Urbana-Champaign have identified specific biomarkers for CMD, which might reduce future hospitalizations.

30 Jun 2021

Researchers identify key protein that allows cancer-destroying viruses to enter tumor cells

Researchers from the Laboratory of Oncolytic-Virus-Immuno-Therapeutics (LOVIT) at the LIH Department of Oncology (DONC) are working on the development of novel anticancer strategies based on oncolytic viruses, "good" viruses that can specifically infect, replicate in and kill cancer cells.

30 Jun 2021

New biomarkers can predict HIV remission after antiretroviral therapy interruption

New biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are critical for the development of new therapeutic strategies that can achieve infection control without ART, a condition defined as functional cure.

29 Jun 2021

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

The LSL60101 compound, a specific ligand of the I2-IR receptors in the brain, could shed light on the development of future strategies against Alzheimer's disease.

29 Jun 2021

IU School of Medicine wins $30 million NIA funding to study Alzheimer’s disease and related dementias

National Centralized Repository for Alzheimer's Disease and Related Dementias grant has been renewed for another five years with funding expected to total $30 million from the National Institute on Aging (NIA), within the National Institutes of the Health.

29 Jun 2021

Clinical observations show acute myocarditis developed after mRNA COVID-19 vaccination

Four patients suffering from acute myocarditis after mRNA COVID-19 vaccination suggests that further investigation is needed.

29 Jun 2021

Scientists develop a simple, noninvasive diagnostic solution for Alzheimer's disease

An international research team led by HKUST has developed a simple but robust blood test from Chinese patient data for early detection and screening of Alzheimer's disease (AD) for the first time, with an accuracy level of over 96%.

28 Jun 2021

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms of neurotransmitter metabolism genes were studied in patients with prostate cancer (PC) characterized by either reduced or extended serum prostate-specific antigen doubling time corresponding to unfavorable and favorable disease prognosis respectively.

28 Jun 2021

Mutation-signature–associated metrics predict cancer progression in patients

Oncotarget published "Predicting clinical outcomes using cancer progression associated signatures" which reported somatic mutation signatures are an informative facet of cancer etiology, however they are rarely useful for predicting patient outcome.

28 Jun 2021

Multisystem Inflammatory Syndrome in Children significantly affects more Black and Latino children

Multisystem Inflammatory Syndrome in Children (MIS-C) significantly affected more Black and Latino children than white children, with Black children at the highest risk, according to a new observational study of 124 pediatric patients treated at Children's National Hospital in Washington, D.C.

25 Jun 2021

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

A new University of California, Irvine-led study finds that the persistence of a marker of chronic cellular stress, previously associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), also takes place in the brains of Huntington's disease (HD) patients.

24 Jun 2021

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

Now, a new study published on the medRxiv* preprint server proposes a rapid method to identify the mutations in B.1.1.7 (N501Y mutation and H69/V70 deletion) and the impact of this variant on various biomarkers in hospitalized patients. This is the first study that correlates the biomarker levels to SARS-CoV-2 variants.

23 Jun 2021

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

A new study published on the bioRxiv* server describes the changes in the representation of a subset of activated monocytes in this group of patients.

23 Jun 2021

Researchers study COVID-19 immune dysfunction in relation to phosphatidylserine

Often patients suffering from COVID-19 (coronavirus disease) show striking immune dysregulation - causing increased morbidity and mortality. Mechanisms for adaptive immune disturbance, lymphopenia, and thromboinflammation in COVID-19 are still poorly understood.

23 Jun 2021

Biomarker News and Research

Further Reading

Dimeric IgA antibodies help identify recent SARS-CoV-2 infection

EULAR Patient Research Partners join in new research project to advance treatment of psoriatic arthritis

Researchers highlight easily adoptable methods to improve outcomes for patients with gastroesophageal cancer

Salivary markers of oxidative stress during severe COVID-19

New PET imaging method tracks immunotherapeutic efficacy in mouse models

Discovery of blood biomarker opens new perspectives for dietary prevention of AMD-related risks

Researchers identify specific biomarkers for coronary microvascular disease

Researchers identify key protein that allows cancer-destroying viruses to enter tumor cells

New biomarkers can predict HIV remission after antiretroviral therapy interruption

LSL60101 compound improves cognitive deficit in murine models with Alzheimer’s

IU School of Medicine wins $30 million NIA funding to study Alzheimer’s disease and related dementias

Clinical observations show acute myocarditis developed after mRNA COVID-19 vaccination

Scientists develop a simple, noninvasive diagnostic solution for Alzheimer's disease

Study explores the potential role of gene polymorphisms in pathogenesis of prostate cancer

Mutation-signature–associated metrics predict cancer progression in patients

Multisystem Inflammatory Syndrome in Children significantly affects more Black and Latino children

Biomarker of chronic cellular stress is associated with Huntington's disease, shows study

A study of circulating biomarkers in hospitalized patients infected with SARS-CoV-2 alpha variant

CD39+ monocyte count higher in pregnant than non-pregnant COVID-19 patients

Researchers study COVID-19 immune dysfunction in relation to phosphatidylserine

Industry Focus eBook - Protein Analysis (3rd edition) eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

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