Cell Death News and Research

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Newly discovered compound causes cancer cell death, whilst sparing healthy cells

Researchers have discovered a compound that can trigger cancer cells to self-destruct, without causing any damage to healthy cells.

10 Oct 2017

Cells lining blood vessels in the lungs exposed to bacterial toxins don’t die easy, UIC study says

Cells lining blood vessels in the lungs that are exposed to bacterial toxins don't die easy, according to a new study led by researchers at the University of Illinois at Chicago College of Medicine.

10 Oct 2017

UCLA scientists discover potential combination treatment for brain cancer in adults

UCLA scientists have discovered a potential combination treatment for glioblastoma, the deadliest form of brain cancer in adults. The three-year study led by Dr. David Nathanson, a member of UCLA's Jonsson Comprehensive Cancer Center, found that the drug combination tested in mice disrupts and exploits glucose intake, essentially cutting off the tumor's nutrients and energy supply.

9 Oct 2017

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

9 Oct 2017

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

An international team led by scientists at the National Institutes of Health is the first to discover a new way that cells fix an important and dangerous type of DNA damage known as a DNA-protein cross-link.

6 Oct 2017

Research explains why mTOR inhibitors show limited ability to kill cancer

Anti-cancer drugs called mTOR inhibitors slow the growth of cancer cells but show limited ability to cause cancer cell death. New studies explain why.

6 Oct 2017

Scientists explore the reason behind impaired sense of smell in Parkinson's disease

The first symptom of Parkinson's disease is often an impaired sense of smell. This neurodegenerative disease primarily causes irreparable damage to nerve cells in a brain area involved in movement control.

30 Sep 2017

Drug combination produces synergistic effect against growth of triple-negative breast cancer

In the hunt for novel treatments against an aggressive form of breast cancer, researchers combined a new protein inhibitor with a chemotherapy drug to create a powerful combination that resulted in cancer cell death.

26 Sep 2017

Alternative splicing may also trigger cancer, study shows

Cancer, which is one of the leading causes of death worldwide, arises from the disruption of essential mechanisms of the normal cell life cycle, such as replication control, DNA repair and cell death.

22 Sep 2017

New device can monitor mitochondria in the heart to predict cardiac arrest

A new device can assess in real time whether the body's tissues are receiving enough oxygen and, placed on the heart, can predict cardiac arrest in critically ill heart patients, report researchers at Boston Children's Hospital and scientists from Cambridge device maker Pendar Technologies.

21 Sep 2017

UM SOM research identifies four pathogens responsible for majority of diarrheal illnesses

Each year, more than half a million deaths among children under five years of age around the world are caused by diarrheal diseases -- largely due to insufficient access to adequate hygiene, sanitation and clean drinking water.

11 Sep 2017

Researchers discover major mechanism in development of liver cancer

Liver cancer is the second-leading cause of cancer-related death and represents the fastest rising cancer worldwide. In most cases, the tumor develops in patients with chronic liver disease.

11 Sep 2017

CWRU professor wins $3.9 million NIH grant to identify countermeasures against chemical hazards

Kurt Lu, MD, assistant professor of dermatology at Case Western Reserve University School of Medicine, has received a five year, $3.9 million grant from the National Institutes of Health to expand countermeasures against chemical threats, including mustard gas and mustard-related compounds.

7 Sep 2017

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Morbid obesity affects the liver: Almost one-third of all adults suffer from chronic fatty liver disease, which can lead to infections and even trigger cancer. Researchers at the University Children's Hospital Zurich and the University of Zurich have now found a signaling pathway in cells that play an important role in the development of fatty liver disease.

7 Sep 2017

Study sheds light on virulence strategy of intracellular bacteria that cause legionellosis

Intracellular pathogens adopt various strategies to circumvent the defences of the host cell and to proliferate intracellularly. One specific strategy is to target host organelles like the mitochondria. Mitochondria are well-defined cytoplasmic organelles, which take part in a variety of cellular metabolic functions.

7 Sep 2017

Biodegradable nanoparticle injected after spinal cord injury limits damage

After a spinal cord injury, a significant amount of secondary nerve damage is caused by inflammation and internal scarring that inhibits the ability of the nervous system to repair itself.

5 Sep 2017

STING signaling pathway induces apoptosis in T cells

EPFL scientists show that the STING signaling pathway, which helps coordinate the innate immune system, causes cell death in T cells of the adaptive immune system. This “killing” effect includes cancerous T cells, and has implications for treating T cell-derived cancers.

5 Sep 2017

FDA approves drug to treat patients with newly diagnosed CD33-positive AML

The U.S. Food and Drug Administration today approved Mylotarg (gemtuzumab ozogamicin) for the treatment of adults with newly diagnosed acute myeloid leukemia whose tumors express the CD33 antigen (CD33-positive AML).

1 Sep 2017

Defect in DNA repair machinery causes underdevelopment of neural network

DNA is the computer code that programs every event in the body. Despite the importance of DNA fidelity, as the body develops, cells grow and replicate, DNA is constantly turned over. This repeated process can compromise the DNA, which is why the body has many DNA repair machineries.

30 Aug 2017

Study reveals new opportunities for treatment of Type 2 diabetes

Bacteria may be responsible for more than we suspect. Especially when it comes to inflammatory diseases such as Type 2 diabetes.

29 Aug 2017

Cell Death News and Research

Newly discovered compound causes cancer cell death, whilst sparing healthy cells

Cells lining blood vessels in the lungs exposed to bacterial toxins don’t die easy, UIC study says

UCLA scientists discover potential combination treatment for brain cancer in adults

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Scientists discover how ZATT protein fixes DNA damage caused by cancer treatment

Research explains why mTOR inhibitors show limited ability to kill cancer

Scientists explore the reason behind impaired sense of smell in Parkinson's disease

Drug combination produces synergistic effect against growth of triple-negative breast cancer

Alternative splicing may also trigger cancer, study shows

New device can monitor mitochondria in the heart to predict cardiac arrest

UM SOM research identifies four pathogens responsible for majority of diarrheal illnesses

Researchers discover major mechanism in development of liver cancer

CWRU professor wins $3.9 million NIH grant to identify countermeasures against chemical hazards

Researchers find signaling pathway in cells that plays key role in development of fatty liver disease

Study sheds light on virulence strategy of intracellular bacteria that cause legionellosis

Biodegradable nanoparticle injected after spinal cord injury limits damage

STING signaling pathway induces apoptosis in T cells

FDA approves drug to treat patients with newly diagnosed CD33-positive AML

Defect in DNA repair machinery causes underdevelopment of neural network

Study reveals new opportunities for treatment of Type 2 diabetes

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