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Genome-wide study finds link between CHD1L gene and HIV control

"We searched for human genetic variation that associates with spontaneous control of HIV and identified a novel region in the genome that is only variable in populations of African ancestries," says Professor Jacques Fellay at EPFL's School of Life Sciences.

2 Aug 2023

Insilico Medicine uses AI to discover novel SIK2 inhibitors

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.

2 Aug 2023

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

With a survival rate in the single digits, pancreatic ductal adenocarcinoma (PDAC) is highly lethal. In fact, by the time PDAC is clinically diagnosed, it is already considered incurable via surgery or other means in up to 90% of patients.

2 Aug 2023

Is there clinical value in screening healthy children with genome sequencing compared with a gene panel for medically actionable pediatric conditions?

Researchers compared the efficacy of proactive genome sequencing and a medically actionable gene panel in identifying potential risk for pediatric-onset disorders in healthy newborns and children.

2 Aug 2023

What are the mediators linking cardiometabolic risk factors and severe COVID-19?

Researchers performed a genome-wide association study to explore whether biomarker levels are causally related to COVID-19 hospitalization.

2 Aug 2023

Analytical and clinical evaluation of antigen-based rapid diagnostic tests against the most encountered SARS-CoV-2 variants

A recent study has assessed the sensitivity of Ag-RDTs against the most prevalent BA.5 Omicron sub-lineage.

2 Aug 2023

Cancer's silent progression: research delves into evolutionary clues in breast cancer

Researchers performed phylogenetic analyses to trace the evolution of breast cancer and precursor lesions.

2 Aug 2023

Genomic sequencing: A key tool for responding to pandemics

Many of the answers for effectively responding to a pathogen lie in its genome.

1 Aug 2023

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

A Penn Medicine and Children's Hospital of Philadelphia (CHOP) team will seek to develop treatments for three rare, incurable genetic diseases with the help of a $26 million grant from the National Institutes of Health (NIH).

1 Aug 2023

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Researchers at City of Hope, one of the largest cancer research and treatment organizations in the United States, today published a new study explaining how they took a protein once thought to be too challenging for targeted therapy, proliferating cell nuclear antigen (PCNA), and developed a targeted chemotherapy that appears to annihilate all solid tumors in preclinical research.

1 Aug 2023

Study highlights metabolite targets for depression prevention that are easily modifiable through diet interventions

Researchers used a UHPLC and mass spectrometry-based Metabolon platform to identify and characterize circulating metabolites associated with depression.

1 Aug 2023

Novel algorithm characterizes RNA motifs in SARS-CoV and SARS-CoV-2

Researchers developed a novel algorithm to analyze large genomic datasets of RNA viruses, applying it to SARS-CoV-2 and SARS-CoV.

1 Aug 2023

Investigating the neurological effects of SARS-CoV-2: anosmia and neuroinvasion as separate phenomena

A group of researchers investigated the neurotropic potential of SARS-CoV-2 and its variants by studying their ability to invade the brain through the olfactory pathway in hamsters.

1 Aug 2023

Insights into the relationship between COVID-19 and mental health

Researchers investigated the causal consequences and genetic mechanisms that link the results of SARS-CoV-2 to anxiety disorders.

1 Aug 2023

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Researchers compared the shared genetic risk and biological foundations of neurological and mental illnesses.

1 Aug 2023

Chinese researchers sequence the genomes of over 100 oat plants

Oat is among the top ten cereal crop species in terms of global production. It can adapt to different climates, and farmers can grow it successfully even in harsh environments where other crops such as rice and corn fail. However, not all oat plants are the same.

31 Jul 2023

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Early on, every stem cell faces a fateful choice. During skin development, for instance, the embryonic epidermis begins as a single layer of epidermal progenitor cells.

31 Jul 2023

Genetics may explain why some people are more likely to participate in genetic studies

Why do some people take part in genetic studies while others do not? The answer may lie within our genetic makeup.

31 Jul 2023

New reference database Greengenes2 improves reproducibility of microbiome studies

Two leading sequencing techniques are no longer at odds, thanks to an international effort led by scientists at University of California San Diego.

27 Jul 2023

Transcription factors may drive development of different colorectal cancer subtypes

New research in colorectal cancers directed by investigators at the Johns Hopkins Kimmel Cancer Center suggests that expression of transcription factors — proteins that help turn specific genes on or off by binding to nearby DNA — may play a central role in the degree of DNA methylation across the genome, contributing to the development of different subtypes of these cancers.

27 Jul 2023

Genome News and Research

Genome-wide study finds link between CHD1L gene and HIV control

Insilico Medicine uses AI to discover novel SIK2 inhibitors

TTUHSC researcher receives $1.76 million grant to investigate new pancreatic cancer treatment

Is there clinical value in screening healthy children with genome sequencing compared with a gene panel for medically actionable pediatric conditions?

What are the mediators linking cardiometabolic risk factors and severe COVID-19?

Analytical and clinical evaluation of antigen-based rapid diagnostic tests against the most encountered SARS-CoV-2 variants

Cancer's silent progression: research delves into evolutionary clues in breast cancer

Genomic sequencing: A key tool for responding to pandemics

Penn Medicine and CHOP receive $26 million NIH grant to develop treatments for three rare genetic diseases

Phase 1 clinical trial underway to test City of Hope-developed cancer treatment

Study highlights metabolite targets for depression prevention that are easily modifiable through diet interventions

Novel algorithm characterizes RNA motifs in SARS-CoV and SARS-CoV-2

Investigating the neurological effects of SARS-CoV-2: anosmia and neuroinvasion as separate phenomena

Insights into the relationship between COVID-19 and mental health

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Chinese researchers sequence the genomes of over 100 oat plants

Rockefeller researchers reveal the mechanisms behind malignant turn of events in cancer

Genetics may explain why some people are more likely to participate in genetic studies

New reference database Greengenes2 improves reproducibility of microbiome studies

Transcription factors may drive development of different colorectal cancer subtypes

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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