Mouse Model News and Research

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'Digital twins' of individual patients may help find best medication to each patient

Advanced computer models of diseases can be used to improve diagnosis and treatment. The goal is to develop the models to "digital twins" of individual patients.

30 Jul 2019

Combination therapy could be a promising treatment for late-stage acute lymphoblastic leukemia

Acute lymphoblastic leukemia accounts for one in five adult leukemias, and is the most common pediatric cancer in the United States.

29 Jul 2019

Asthma drug can inhibit changes in early stages of diabetic retinopathy

In a study published July 26 online in the journal Diabetes, physician-researchers from University Hospitals Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine found that the asthma medication montelukast (brand name Singulair) can inhibit early changes in diabetic retinopathy, the eye disease which develops due to diabetes, in a mouse model of type 1 diabetes.

29 Jul 2019

Scientists reverse social traits associated with autism in mouse model

Research has been ongoing in the field of genetic mutations and changes and brain and other neural disorders including Autism Spectrum Disorders (ASD) and a new study in mice models of autism has shown a possible link between mutations or deletions of the SHANK3 gene and a rare disorder called Phelan-McDermid syndrome and ASD.

29 Jul 2019

Scientists discover novel mechanism of action for NK cells in checkpoint inhibitor for cancer

PD-L1 checkpoint inhibitors are a powerful and growing form of immunotherapy used to treat melanoma, kidney cancer, head and neck cancers, Hodgkin's lymphoma and other cancers.

27 Jul 2019

Australian researchers discover gene that plays key role in aggressive childhood cancer

Neuroblastoma accounts for 15% of total childhood cancer deaths. The survival rate of high-risk neuroblastoma patients is 50%.

27 Jul 2019

Study provides clues to neural circuits underlying social deficits linked to ASD

Although psychiatric disorders can be linked to particular genes, the brain regions and mechanisms underlying particular disorders are not well-understood.

26 Jul 2019

Salk study unlocks new way to target hard-to-treat cancers

Now, a new Salk Institute study, published on July 24, 2019, in the journal Science Advances, shows that researchers could target these hard-to-treat cancers by pursuing drugs that keep a cellular "switch," called CREB, from triggering tumor growth.

25 Jul 2019

Disruption of immune cell behavior may spur heart disease, heart failure

On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie.

From Johns Hopkins Medicine 19 Jul 2019

Low estrogen causes muscle loss in women after menopause

Pioneering research shows the essential role played by the female hormone estrogen in preserving muscle bulk and strength in women.

19 Jul 2019

Researchers develop a more precise version of CRISPR-Cas9 gene-editing system

A gene defect in humans causes progressive hearing loss in humans, resulting in deafness by their mid-20s. The same genetic mutation causes deafness in the Beethoven-mouse model.

18 Jul 2019

Gut infection can lead to a pathology resembling Parkinson's disease

A new study by Montreal scientists published today in Nature demonstrates that a gut infection can lead to a pathology resembling Parkinson's disease in a mouse model lacking a gene linked to the human disease.

17 Jul 2019

Research opens possibility of developing single-dose gene therapy for inherited arrhythmias

Researchers at Boston Children's Hospital report creating the first human tissue model of an inherited heart arrhythmia, replicating two patients' abnormal heart rhythms in a dish, and then suppressing the arrhythmia with gene therapy in a mouse model.

17 Jul 2019

Fungal infection study identifies specific genetic vulnerability among Hmong people

Ten years ago, in Marathon County, Wisconsin, 55 people were sickened by an uncommon fungal infection called blastomycosis. Thirty patients were hospitalized. Two people died.

16 Jul 2019

Novel biomarker-guided approach has potential for treatment of common liver cancer

A study at The University of Texas MD Anderson Cancer Center discovered a cellular pathway tied to cancer that may be beneficial in reducing side effects and extending duration of immunotherapy in some patients with hepatocellular carcinoma, the most common form of liver cancer.

16 Jul 2019

Metabolic enzyme tied to obesity and fatty liver disease

A team of researchers at the Clemson University found that Cyp2b gene, which metabolizes endo and xenobiotics, may be linked to age-onset obesity and dyslipidemia, especially in males.

11 Jul 2019

UCR biomedical professor to investigate how body's cannabis-like molecules influence obesity

More than two-thirds of adults in the United States are overweight or obese. Eating foods containing high levels of fats and sugars -- the "Western diet" -- can lead to obesity and significantly reduce life expectancy.

11 Jul 2019

Research reveals genetic cause of deadly digestive disease in children

Nearly 10 years ago, a group of Israeli clinical researchers emailed Lawrence Berkeley National Laboratory (Berkeley Lab) geneticist Len Pennacchio to ask for his team's help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children.

11 Jul 2019

Researchers report how a popular antidepressant drug could rewire the brain

Prozac, the trade name for the drug fluoxetine, was introduced to the U.S. market for the treatment of depression in 1988.

10 Jul 2019

Retina can restructure itself following gene therapy

Following gene therapy, the retina can restructure itself and regain normal light responses, according to research in mice published in JNeurosci.

From Society for Neuroscience 10 Jul 2019

Mouse Model News and Research

'Digital twins' of individual patients may help find best medication to each patient

Combination therapy could be a promising treatment for late-stage acute lymphoblastic leukemia

Asthma drug can inhibit changes in early stages of diabetic retinopathy

Scientists reverse social traits associated with autism in mouse model

Scientists discover novel mechanism of action for NK cells in checkpoint inhibitor for cancer

Australian researchers discover gene that plays key role in aggressive childhood cancer

Study provides clues to neural circuits underlying social deficits linked to ASD

Salk study unlocks new way to target hard-to-treat cancers

Disruption of immune cell behavior may spur heart disease, heart failure

Low estrogen causes muscle loss in women after menopause

Researchers develop a more precise version of CRISPR-Cas9 gene-editing system

Gut infection can lead to a pathology resembling Parkinson's disease

Research opens possibility of developing single-dose gene therapy for inherited arrhythmias

Fungal infection study identifies specific genetic vulnerability among Hmong people

Novel biomarker-guided approach has potential for treatment of common liver cancer

Metabolic enzyme tied to obesity and fatty liver disease

UCR biomedical professor to investigate how body's cannabis-like molecules influence obesity

Research reveals genetic cause of deadly digestive disease in children

Researchers report how a popular antidepressant drug could rewire the brain

Retina can restructure itself following gene therapy

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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