Preclinical News and Research

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A complete transcriptomic analysis of astrocytes in Alzheimer's disease

An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.

18 Mar 2022

Study shows BCG vaccination reduces SARS-CoV-2-induced lung inflammation in hamsters

Researchers tested the effectiveness of the BCG vaccine in SARS-CoV-2-infected Syrian hamsters.

18 Mar 2022

Excessive daytime napping among older people may foreshadow dementia

Daytime napping among older people is a normal part of aging – but it may also foreshadow Alzheimer's disease and other dementias.

18 Mar 2022

New approach radically increases the success of breast cancer immunotherapy

A study published in the journal Nature Cancer, carried out within the Cancer Programme at the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar) by the Cancer Stem Cells and Metastasis Dynamics Laboratory, led by Dr. Toni Celià-Terrassa, and the Laboratory of Molecular Cancer Therapy, coordinated by Dr. Joan Albanell, with the participation of international centers, has discovered an approach that radically increases the success of immunotherapy in one of the most aggressive types of tumors, triple-negative breast cancer.

17 Mar 2022

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Researchers explored neuroinflammation and COVID-19-induced ischemic stroke recovery.

17 Mar 2022

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

High-grade serous carcinoma is the most aggressive form of ovarian cancer and accounts for the majority of advanced-stage cases.

16 Mar 2022

SLU physician-scientist receives NIH funding for Short Bowel Syndrome research

A Saint Louis University School of Medicine scientist and SLUCare physician has received funding from the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health (NIH) to study Short Bowel Syndrome (SBS).

16 Mar 2022

Irradiation of tumors with laser protons tested for the first time

Irradiation with fast protons is a more effective and less invasive cancer treatment than X-rays. However, modern proton therapy requires large particle accelerators, which has experts investigating alternative accelerator concepts, such as laser systems to accelerate protons.

14 Mar 2022

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Tiny structures called nanoparticles can be used to carry substances to certain parts of the body - for example, to deliver a chemotherapy drug to a tumor.

11 Mar 2022

Novel nanoparticles enable synergy of radiation and photodynamic therapies of deep tumor tissues

Researchers Dr Yansong Feng and Prof. Hong Zhang at the Van 't Hoff Institute for Molecular Sciences at the University of Amsterdam (UvA) have designed and synthesized novel multi-layered, multi-functional nanoparticles that enable a combination of radiotherapy and photodynamic therapy for deep cancer tissue.

10 Mar 2022

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Researchers explored strategies to develop an mRNA-based COVID-19 vaccine that could elicit safer and wider protection against SARS-CoV-2 variants of concern.

10 Mar 2022

Anti-Müllerian hormone plays an active role in polycystic ovary syndrome

High levels of anti-Mullerian hormone (AMH) have traditionally been thought of as merely a passive byproduct of polycystic ovary syndrome (PCOS), but a new preclinical study by Weill Cornell Medicine researchers suggests that the hormone plays an active role in the disorder and may contribute to problems with ovulation and fertility.

10 Mar 2022

A medium-chain fatty acid may help protect against heart attack injuries

A medium-chain fatty acid found in energy drinks might one day help protect against heart attack injuries.

9 Mar 2022

Patient-derived circulating tumor cells could be used to identify drug targets for leptomeningeal disease

Leptomeningeal disease is a rare complication of several different types of cancer, including melanoma. It occurs when tumor cells migrate to the cerebrospinal fluid and the tissue that surrounds the brain and spinal column known as the meninges.

8 Mar 2022

Biotech spinout receives $42 million to develop 'future-proofed' coronavirus vaccines

Prime Minister Boris Johnson today announced that DIOSynVax, a biotech spinout of the University of Cambridge, will receive $42million to develop a vaccine candidate that could provide protection against both existing and future variants of SARS-CoV-2 - the virus that causes COVID-19 - as well as other major coronaviruses, including those that cause SARS and MERS.

8 Mar 2022

Preclinical News and Research

A complete transcriptomic analysis of astrocytes in Alzheimer's disease

Study shows BCG vaccination reduces SARS-CoV-2-induced lung inflammation in hamsters

Excessive daytime napping among older people may foreshadow dementia

New approach radically increases the success of breast cancer immunotherapy

Narrative review reports two important mediators in SARS-CoV-2-induced ischemic stroke recovery

Novel metabolic mechanisms contribute to how ovarian cancer evades immune attack, research finds

SLU physician-scientist receives NIH funding for Short Bowel Syndrome research

Irradiation of tumors with laser protons tested for the first time

Lower, more frequent doses of nanomedicines may provide additional benefits for cancer patients

Novel nanoparticles enable synergy of radiation and photodynamic therapies of deep tumor tissues

Study finds chimeric mRNA induces potent and broadly acting neutralizing antibodies against SARS-CoV-2 variants

Anti-Müllerian hormone plays an active role in polycystic ovary syndrome

A medium-chain fatty acid may help protect against heart attack injuries

Patient-derived circulating tumor cells could be used to identify drug targets for leptomeningeal disease

Biotech spinout receives $42 million to develop 'future-proofed' coronavirus vaccines

Illinois Tech receives $2.17 million NIH grant to develop drug treatments for cholera

Study identifies new immune checkpoint that may be exploited for cancer treatment

Current and future perspectives of mRNA technology

Current progress in SARS-CoV-2 vaccine candidates

Researchers discover functional links between potassium channel gene variants and neonatal epilepsy

New Approach Methodologies, the 3Rs and Multimodal Imaging in Preclinical Research - eBook eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics