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NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month.

2 Sep 2024

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

The SGLT2 inhibitor empagliflozin confers kidney-protective benefits and can therefore be given safely and effectively to patients when they are hospitalized for acute myocardial infarction (MI), a Mount Sinai-led global team of researchers has shown.

1 Sep 2024

Study links blood markers to long-term cardiovascular risk in women

Research supported by the National Institutes of Health has found that measuring two types of fat in the bloodstream along with C-reactive protein (CRP), a marker of inflammation, can predict a woman's risk for cardiovascular disease decades later.

1 Sep 2024

RESHAPE-HF2 trial shows M-TEER as effective treatment for functional mitral regurgitation

Mitral transcatheter edge-to-edge repair (M-TEER) reduced cardiovascular death and heart failure (HF)-related hospitalizations with improved health status in patients with HF and moderate to severe functional mitral regurgitation (FMR), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

MATTERHORN trial finds TEER non-inferior to surgery for secondary mitral regurgitation

There was no difference in efficacy between transcatheter edge-to-edge repair (TEER) and surgery in patients with secondary mitral regurgitation (MR), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

No-touch graft harvesting shows no advantage over conventional technique in CABG

No-touch graft harvesting did not appear to be beneficial compared with the conventional technique for coronary artery bypass grafting (CABG), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

T-TEER shows promising outcomes in severe tricuspid regurgitation patients after one year

Tricuspid transcatheter edge-to-edge repair (T-TEER) significantly reduced the severity of secondary tricuspid regurgitation and improved quality of life after 1 year, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

Research suggests flexible approach to antiplatelet management after drug-eluting stent implantation

Among patients undergoing non-cardiac surgery more than 1 year after coronary drug-eluting stent (DES) implantation, there was no difference with respect to ischaemic outcomes or major bleeding between perioperative aspirin monotherapy and receiving no antiplatelet therapy, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

TAVI outperforms surgery in reducing complications for women with severe aortic stenosis

Transcatheter aortic valve implantation (TAVI) was superior to surgical aortic valve replacement for reducing death, stroke or rehospitalization in women with severe aortic stenosis, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

Study finds no added benefit to routine potassium supplementation after CABG

For the prevention of new-onset atrial fibrillation (AF) after isolated coronary artery bypass graft (CABG) surgery, giving potassium supplements only when levels dropped below the lower limit of normal was non-inferior to routinely supplementing potassium to the upper limit of normal, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

New imaging technology enhances detection of tumor remnants

The imaging techniques currently used in biological research cannot penetrate into deeper tissue layers.

30 Aug 2024

New ESC guidelines highlight broader approach to managing chronic coronary syndromes

The 2024 ESC Guidelines on the management of chronic coronary syndromes (CCS) include a focus on both larger and smaller blood vessels of the heart; new models to estimate chances of blocked large arteries (so-called obstructive coronary artery disease); optimal selection and sequence of tests; drugs and interventions to prevent disease complications and improve symptoms, and the fundamental role of patient involvement.

30 Aug 2024

Updated atrial fibrillation guidelines focus on risk management and patient-centered care

The 2024 ESC Guidelines for the management of atrial fibrillation, developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS), contain a number of new approaches and treatment-specific recommendations to help manage the surging numbers of patients with AF worldwide.

30 Aug 2024

Major surgery complications unaffected by use of renin-angiotensin system inhibitors

There was no difference in major post-operative complications in patients who continued vs. stopped renin-angiotensin system inhibitors (RASIs) before non-cardiac surgery, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

30 Aug 2024

ESC consensus statement highlights obesity's impact on cardiovascular disease

The ESC Clinical Consensus Statement on Obesity and Cardiovascular Disease, presented at this year's ESC Congress (London, UK, 30 August to 2 September) summarizes current evidence on the epidemiology and etiology of obesity; the interplay between obesity, cardiovascular risk factors and cardiac conditions; the clinical management of patients with cardiac disease and obesity; and weight loss strategies including lifestyle changes, interventional procedures, and anti-obesity medications with particular focus on their impact on cardiometabolic risk and cardiac outcomes.

30 Aug 2024

The Arctic Sea revealed as a potential treasure trove for new medicines

Researchers discovered new antivirulence and antibacterial compounds from Arctic marine actinobacteria, offering potential solutions to combat antibiotic-resistant E. coli infections.

30 Aug 2024

Marijuana use linked to elevated nicotine levels in plastic surgery patients

Marijuana use is common among patients considering plastic surgery and is associated with elevated nicotine levels on laboratory tests, reports a paper in the September issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.

29 Aug 2024

Exploring the role of suvorexant in reducing delirium among older adults

Delirium is a sudden onset and temporary state of disturbed consciousness or cognition, occurring due to underlying medical issues like fever or alcohol withdrawal.

29 Aug 2024

Multimodal approaches enhance detection of Idiopathic Normal Pressure Hydrocephalus

A recent case report published in Cyborg Bionic Systems details the diagnosis of Idiopathic Normal Pressure Hydrocephalus (iNPH) using multimodality diagnostic approaches, highlighting significant advancements in medical diagnostics and patient care.

29 Aug 2024

Tirzepatide beats semaglutide in lowering diabetes risk and cardiovascular events in obesity patients

A study published in eClinicalMedicine found that tirzepatide outperforms semaglutide in reducing the risk of type 2 diabetes and major cardiovascular events among individuals with obesity, with or without existing diabetes, while also achieving greater weight loss.

28 Aug 2024

Surgery News and Research

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

Study links blood markers to long-term cardiovascular risk in women

RESHAPE-HF2 trial shows M-TEER as effective treatment for functional mitral regurgitation

MATTERHORN trial finds TEER non-inferior to surgery for secondary mitral regurgitation

No-touch graft harvesting shows no advantage over conventional technique in CABG

T-TEER shows promising outcomes in severe tricuspid regurgitation patients after one year

Research suggests flexible approach to antiplatelet management after drug-eluting stent implantation

TAVI outperforms surgery in reducing complications for women with severe aortic stenosis

Study finds no added benefit to routine potassium supplementation after CABG

New imaging technology enhances detection of tumor remnants

New ESC guidelines highlight broader approach to managing chronic coronary syndromes

Updated atrial fibrillation guidelines focus on risk management and patient-centered care

Major surgery complications unaffected by use of renin-angiotensin system inhibitors

ESC consensus statement highlights obesity's impact on cardiovascular disease

The Arctic Sea revealed as a potential treasure trove for new medicines

Marijuana use linked to elevated nicotine levels in plastic surgery patients

Exploring the role of suvorexant in reducing delirium among older adults

Multimodal approaches enhance detection of Idiopathic Normal Pressure Hydrocephalus

Tirzepatide beats semaglutide in lowering diabetes risk and cardiovascular events in obesity patients

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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