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UNC researchers find new enzyme target for treating chronic pain

Researchers at the UNC School of Medicine have found a new target for treating chronic pain: an enzyme called PIP5K1C.

22 May 2014

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

Disease progression-free survival is similar for patients with non-small-cell lung cancer and epidermal growth factor receptor mutations whether they receive erlotinib or gefitinib, show the results of a South Korean study.

21 May 2014

Genprex initiates Phase II clinical trial of Oncoprex for late-stage lung cancer patients

Genprex, Inc. announced today that it has enrolled the first patient in a clinical trial evaluating its lead product candidate Oncoprex in combination with erlotinib (Tarceva) for late-stage lung cancer patients.

21 May 2014

Vitamin E-rich oils may increase incidence of asthma, says study

A large new Northwestern Medicine- study upends our understanding of vitamin E and ties the increasing consumption of supposedly healthy vitamin E-rich oils -- canola, soybean and corn - to the rising incidence of lung inflammation and, possibly, asthma.

21 May 2014

Researchers identify drugs to slow progression of idiopathic pulmonary fibrosis

Researchers in separate clinical trials found two drugs slow the progression of idiopathic pulmonary fibrosis, a fatal lung disease with no effective treatment or cure, and for which there is currently no therapy approved by the Food and Drug Administration.

19 May 2014

CHOP oncologist receives Lifetime Achievement Award at ANRA association's international meeting

The Advances in Neuroblastoma Research Association (ANRA) is conferring its highest honor on pediatric oncologist Garrett M. Brodeur, M.D., of the Cancer Center at The Children's Hospital of Philadelphia (CHOP).

16 May 2014

Novel targeted drug shows promise in treating patients with advanced pigmented villonodular synovitis

A novel targeted drug shows promise in treating patients with advanced pigmented villonodular synovitis (PVNS), a rare neoplastic joint disorder, according to new phase I data from Memorial Sloan Kettering Cancer Center and other institutions highlighted to media today in advance of the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO), which will take place from May 30 to June 3 in Chicago.

15 May 2014

Phase I study reveals abemaciclib drug shows evidence of single-agent activity in NSCLC patients

Abemaciclib, an oral drug administered twice daily, currently in development by Eli Lilly and Company (NYSE: LLY), has shown evidence of single-agent activity in patients with advanced non-small cell lung cancer in a Phase I study released ahead of the American Society of Clinical Oncology (ASCO) Annual Meeting to be held in Chicago, Ill.

15 May 2014

SGK1 enzyme, asthma and cancer therapies: an interview with Dr. Jonathan D. Powell, Johns Hopkins Kimmel Cancer Center

SGK1 stands for serum/glucocorticoid-regulated kinase 1. SGK1 is a member of the AGC kinase family, which is a huge family of kinases.

13 May 2014

Amakem commences Phase 2 dose-ranging study of AMA0076 drug for treatment of glaucoma

Amakem Therapeutics, a clinical stage ophthalmology company, today announced that first patients have commenced treatment in a Phase 2 dose-ranging study of its lead drug candidate, AMA0076 for the treatment of glaucoma.

13 May 2014

Melbourne researchers find link between necroptosis and inflammatory disease

A team of Melbourne researchers has shown a recently discovered type of cell death called necroptosis could be the underlying cause of inflammatory disease.

13 May 2014

Researchers use molecular diagnostic methods to detect cancer

The ABC Medical Center, located in Mexico City, implemented various molecular diagnostic methods that can detect the genetic alterations in several types of cancer, so they can select a personalized therapy for each patient and direct it against the mutated genes that cause disease.

13 May 2014

2 genes work together to drive most lethal forms of prostate cancer

Two genes work together to drive the most lethal forms of prostate cancer, according to new research from the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center (CUMC).

13 May 2014

Verastem announces expansion of ongoing COMMAND study in Japan

Verastem, Inc., focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells, today announced the expansion of its ongoing COMMAND study to include clinical trial sites in Japan.

12 May 2014

Study of rare childhood neurodegenerative diseases identifies new source of DNA damage

St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging.

12 May 2014

Kinase News and Research

UNC researchers find new enzyme target for treating chronic pain

Erlotinib, gefitinib have similar efficacy in NSCLC patients with EGFR mutation

Genprex initiates Phase II clinical trial of Oncoprex for late-stage lung cancer patients

Vitamin E-rich oils may increase incidence of asthma, says study

Researchers identify drugs to slow progression of idiopathic pulmonary fibrosis

CHOP oncologist receives Lifetime Achievement Award at ANRA association's international meeting

Novel targeted drug shows promise in treating patients with advanced pigmented villonodular synovitis

Phase I study reveals abemaciclib drug shows evidence of single-agent activity in NSCLC patients

SGK1 enzyme, asthma and cancer therapies: an interview with Dr. Jonathan D. Powell, Johns Hopkins Kimmel Cancer Center

Amakem commences Phase 2 dose-ranging study of AMA0076 drug for treatment of glaucoma

Melbourne researchers find link between necroptosis and inflammatory disease

Researchers use molecular diagnostic methods to detect cancer

2 genes work together to drive most lethal forms of prostate cancer

Verastem announces expansion of ongoing COMMAND study in Japan

Study of rare childhood neurodegenerative diseases identifies new source of DNA damage

Chinese herbal formula protects against hippocampal neurons death via non-classical estrogen pathway

Clovis Oncology reports net loss of $30.7 million for first quarter 2014

Genetic changes linked to altered default mode network in psychosis

ARIAD provides update on corporate developments, reports Q1 2014 financial results

IKKβ links vascular inflammation to obesity and atherosclerosis development

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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