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Removing damaged mitochondria may relieve chronic inflammatory conditions

Researchers have discovered a potential new way to treat chronic inflammatory diseases, by eliminating damaged mitochondria before they trigger excessive inflammation.

12 Apr 2019

Active lifestyle influences regenerative capacity of neurons after spinal cord injury

The influence of an active lifestyle on the regenerative capacity of the peripheral nervous system, that is, the set of cranial and spinal nerves that control motor and sensory functions, is described here for the first time, explains Ángel Barco, who has led the participation of the Institute of Neurosciences UMH-CSIC, in Alicante, in this international study.

11 Apr 2019

Single-cell sequencing sheds light on landscape of myeloid cells in lung tumors

The recent emergence of immunotherapy has marked a sea change in research and care for many forms of cancer, bringing new hope to patients and families around the world. For those who respond to treatment, the results can be dramatic.

10 Apr 2019

MDMA has been shown to improve PTSD symptoms, but how?

According to a new study, MDMA can increase the sensitivity of the brain to learning the reward value of social behaviors, which may explain its effects on PTSD.

8 Apr 2019

Gum disease bacterium releases toxins that may cause Alzheimer's

Researchers have provided the strongest evidence to date that a bacterium involved in periodontitis contributes to the development of Alzheimer’s disease, rheumatoid arthritis and aspiration pneumonia.

8 Apr 2019

Promising diagnostic, prognostic tools for onset and progression of ALS

Amyotrophic lateral sclerosis is a motor neuron disease with rampant progression and that it is typically fatal within 5 years of prognosis.

5 Apr 2019

New hope for treating devastating brain cancer in children

There could be new treatments on the horizon for diffuse intrinsic pontine glioma, or DIPG, a devastating form of brain cancer that afflicts young children and is currently incurable.

5 Apr 2019

Research unravels possible factor for female bias in lupus

The autoimmune disease lupus, which can cause fatigue, a facial rash, and joint pain, strikes females far more often than males. Eight-five percent of people with lupus are female, and their second X chromosome seems partly to blame.

5 Apr 2019

PET images of microglial activation levels could better predict Alzheimer's disease progression

Researchers have discovered a way to better predict progression of Alzheimer's disease. By imaging microglial activation levels with positron emission tomography, researchers were able to better predict progression of the disease than with beta-amyloid PET imaging, according to a study published in the April issue of the Journal of Nuclear Medicine.

4 Apr 2019

Developing imaging techniques for early detection of eye and brain diseases

The eyes may be the window to the soul, but to scientists, they are also the window to the brain. In particular, the retina, a delicate light-sensing neural network with specialized cells at the back of the eyeball, is linked directly to the brain via the optic nerve and is considered by some to be part of the brain itself.

4 Apr 2019

Novel strategy to ameliorate symptoms of mitochondrial disease

Diseases affecting mitochondria, the powerhouses of our cells, are often caused by mutations in the mitochondrial DNA. Symptoms of such mitochondrial diseases in mice can be ameliorated by increasing their levels of mitochondrial DNA, according to a study by researchers at Karolinska Institutet.

3 Apr 2019

New mouse model for Joubert Syndrome developed

A new mouse model for Joubert Syndrome has been developed by University of Bath scientists, who hope it will accelerate research to understand how the disease develops as well as help develop and evaluate therapeutic approaches.

3 Apr 2019

Pitt study sheds light on how immune cells help tumors to escape body's defenses

New research from the University of Pittsburgh School of Medicine and the UPMC Hillman Cancer Center sheds light on how tumors use the body's regulators of immunity for their own benefit.

2 Apr 2019

Potential drug targets cause of adult-onset muscular dystrophy

People diagnosed with myotonic dystrophy type 1 have difficulty unclenching muscles due to a genetic defect that generates toxic material within their cells.

1 Apr 2019

Research reveals genomic basis of acute erythroid leukemia

Acute erythroid leukemia is a high-risk cancer with a dismal prognosis, uncertain genetic basis and controversy surrounding the diagnosis. That is changing, thanks to research led by St. Jude Children's Research Hospital that appears today in the journal Nature Genetics.

30 Mar 2019

IASLC 2019 Small Cell Lung Cancer Meeting focuses on immunotherapy and patient perspective

While non-small cell lung cancer is the more common form of lung cancer and attracts the lion's share of the research funding, recent developments in small cell lung cancer may be shifting that slightly.

29 Mar 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

Research Recognition Award will help improve lives of young people with absence epilepsy

The 2019 Epilepsy League Research Recognition Award and prize money of CHF 25,000 is set to benefit young people: Dr. phil. Martina Hubacher is researching “The absent mind – Neurocognition and sleep in young people with absence seizures” at the University Children's Hospital Basel.

25 Mar 2019

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

A synthetic peptide appears to directly disrupt the destructive inflammation that occurs in nephritis, enabling the kidneys to better recover and maintain their important functions, investigators report.

25 Mar 2019

Exposure to dim light at night may contribute to spread of breast cancer to bones

Exposure to dim light at night, which is common in today's lifestyle, may contribute to the spread of breast cancer to the bones, researchers have shown for the first time in an animal study.

25 Mar 2019

Mouse Model News and Research

Removing damaged mitochondria may relieve chronic inflammatory conditions

Active lifestyle influences regenerative capacity of neurons after spinal cord injury

Single-cell sequencing sheds light on landscape of myeloid cells in lung tumors

MDMA has been shown to improve PTSD symptoms, but how?

Gum disease bacterium releases toxins that may cause Alzheimer's

Promising diagnostic, prognostic tools for onset and progression of ALS

New hope for treating devastating brain cancer in children

Research unravels possible factor for female bias in lupus

PET images of microglial activation levels could better predict Alzheimer's disease progression

Developing imaging techniques for early detection of eye and brain diseases

Novel strategy to ameliorate symptoms of mitochondrial disease

New mouse model for Joubert Syndrome developed

Pitt study sheds light on how immune cells help tumors to escape body's defenses

Potential drug targets cause of adult-onset muscular dystrophy

Research reveals genomic basis of acute erythroid leukemia

IASLC 2019 Small Cell Lung Cancer Meeting focuses on immunotherapy and patient perspective

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

Research Recognition Award will help improve lives of young people with absence epilepsy

Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis

Exposure to dim light at night may contribute to spread of breast cancer to bones

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