Dysfunctional neurons repaired in dementia mouse model

Dysfunctional neurons in the hippocampus of adult female mice modeling dementia can be repaired and reconnected to distant parts of the brain, reports a new study published in JNeurosci. The similarity between the mouse model and the human condition underscores the therapeutic potential of targeting these cells in dementia patients.

Dysfunctional neurons repaired in dementia mouse model

Representative images of the hippocampus and Entorhinal cortex. Credit:Terreros-Roncal et al. JNeurosci (2019).

The hippocampus generates new brain cells throughout life and is implicated in neurodegenerative diseases. María Llorens-Martín and colleagues at the Centro de Biología Molecular "Severo Ochoa" (CBMSO, CSIC-UAM) used a mouse model of frontotemporal dementia to investigate the effects of the disease on dentate granule cells.

Compared to control subjects, the researchers observed strikingly similar alterations in newborn neurons from their mouse model and from human brain tissue of patients with frontotemporal dementia. In mice, chemically activating the cells and placing animals in a stimulating environment with running wheels and toys reversed the alterations and restore some of the connectivity disrupted by dementia. If translated to humans, these results suggest potential new directions for combating cognitive decline in the elderly.

Source:

Society for Neuroscience

Journal reference:

Terreros-Roncal, J. et al. (2019) Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia. JNeurosci. doi.org/10.1523/JNEUROSCI.2724-18.2019.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Society for Neuroscience. (2019, May 28). Dysfunctional neurons repaired in dementia mouse model. News-Medical. Retrieved on July 15, 2019 from https://www.news-medical.net/news/20190528/Dysfunctional-neurons-repaired-in-dementia-mouse-model.aspx.

  • MLA

    Society for Neuroscience. "Dysfunctional neurons repaired in dementia mouse model". News-Medical. 15 July 2019. <https://www.news-medical.net/news/20190528/Dysfunctional-neurons-repaired-in-dementia-mouse-model.aspx>.

  • Chicago

    Society for Neuroscience. "Dysfunctional neurons repaired in dementia mouse model". News-Medical. https://www.news-medical.net/news/20190528/Dysfunctional-neurons-repaired-in-dementia-mouse-model.aspx. (accessed July 15, 2019).

  • Harvard

    Society for Neuroscience. 2019. Dysfunctional neurons repaired in dementia mouse model. News-Medical, viewed 15 July 2019, https://www.news-medical.net/news/20190528/Dysfunctional-neurons-repaired-in-dementia-mouse-model.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News-Medical.Net.
Post a new comment
Post
You might also like... ×
Sleep patterns can predict Alzheimer’s pathology later in life