Genomic News and Research

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Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

Abdominal obesity increases risk of pancreatic cancer

Researchers report that abdominal obesity determined by body mass index adjusted waist-to-hip ratio is a significant risk factor for pancreatic cancer.

30 Aug 2022

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Researchers identify and characterize the targets of Vit D on COVID-19 and osteoporosis.

30 Aug 2022

Understanding recombination rates in RNA viruses

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30 Aug 2022

Disrupting a virus’s genome packaging can halt replication, study finds

Like savvy international travelers, viruses know exactly how to pack. With the genetic instructions for the next generation folded just so, snuggled into a custom-made outer covering studded with cell-grabbing proteins, these tiny invaders quest for new digs on the reg.

30 Aug 2022

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Researchers performed a structural bioinformatics analysis to evaluate the binding energy of the SARS-CoV-2 Omicron variants of concern spike protein receptor-binding domain to human angiotensin-converting enzyme 2 receptor compared to other VOCs.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022

Viruses modify host cellular machinery to produce high amounts of viral progeny

The study, published in Nature Communications, shows a new mechanism whereby viruses modify cellular machinery so that it can better read the instructions in the genome of the invading virus.

29 Aug 2022

The clinical and virological outcomes associated with molnupiravir or nirmatrelvir–ritonavir use in hospitalized patients with mild-to-moderate COVID-19

Researchers investigated whether early treatment with oral antivirals prevented all-cause mortality in hospitalized patients infected with SARS-CoV-2 new variant of concern Omicron BA.2 subvariant.

29 Aug 2022

Researchers propose a novel, non-discriminatory classification of the monkeypox virus

Researchers proposed a novel, non-discriminatory classification of the monkeypox virus.

29 Aug 2022

NRL fungal experiment to launch as part of NASA's scheduled Artemis I mission

An experiment prepared by the U.S. Naval Research Laboratory (NRL) will launch as part of NASA's scheduled Artemis I mission to orbit the moon Aug. 29.

26 Aug 2022

Evolution can favor flexible proteins, research suggests

When you think of proteins – the enzymes, signaling molecules, and structural components in every living thing – you might think of single strands of amino acids, organized like beads on a string.

26 Aug 2022

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications.

25 Aug 2022

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

In a new study, researchers assessed the impact of mutagenesis on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and the effects of mutations in the neutral regions and non-neutral regions of the genome.

25 Aug 2022

Facial recognition algorithms show genetic similarities in genetically unrelated look-alike humans

In a new study, researchers identified look-alike humans who were genetically unrelated using facial recognition (FR) algorithms for multi-omics studies.

25 Aug 2022

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

T cells used in immunotherapy treatments can get exhausted by the task of fighting cancer cells or get shutdown as they enter tumors.

24 Aug 2022

SARS-CoV-2 variants of concern emerging from chronic COVID infections, study shows

The coronavirus variants of concern are emerging from chronic, long-term COVID infections in people who may be immune comprised and unable to clear the virus, a new study strongly suggests.

23 Aug 2022

Epistasis leads to the reduction in genetic barrier to COVID-19 neutralizing antibody escape

A new study addresses the important question of how the SARS-CoV-2 virus would evolve in the future to be able to escape diverse and broadly neutralizing antibodies.

23 Aug 2022

Association between infant intestinal microbiome and respiratory diseases of childhood

In a new study, researchers performed a systematic review to assess the association between the composition of infant gut microbiota and childhood respiratory disorders.

23 Aug 2022

Researchers discover how patients with mutations in a DNA sequence develop pancreatic malformations

Researchers at the Centre for Genomic Regulation have identified a DNA sequence that is crucial for pancreatic differentiation and function – and for the first time – describe how it works.

22 Aug 2022

Genomic News and Research

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Abdominal obesity increases risk of pancreatic cancer

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Understanding recombination rates in RNA viruses

Disrupting a virus’s genome packaging can halt replication, study finds

The effects of amino acid substitutions on the affinity of the SARS-CoV-2 spike RBD to the human receptor hACE2

Study reveals a 'stealing' mechanism that contributes to antibody diversity

Viruses modify host cellular machinery to produce high amounts of viral progeny

The clinical and virological outcomes associated with molnupiravir or nirmatrelvir–ritonavir use in hospitalized patients with mild-to-moderate COVID-19

Researchers propose a novel, non-discriminatory classification of the monkeypox virus

NRL fungal experiment to launch as part of NASA's scheduled Artemis I mission

Evolution can favor flexible proteins, research suggests

New approach using CRISPR can engineer massive quantities of cells for therapeutic applications

SARS-CoV-2 mutational spectra based on reconstructed phylogenetic tree

Facial recognition algorithms show genetic similarities in genetically unrelated look-alike humans

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

SARS-CoV-2 variants of concern emerging from chronic COVID infections, study shows

Epistasis leads to the reduction in genetic barrier to COVID-19 neutralizing antibody escape

Association between infant intestinal microbiome and respiratory diseases of childhood

Researchers discover how patients with mutations in a DNA sequence develop pancreatic malformations

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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