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Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Scientists at Roswell Park Comprehensive Cancer Center have identified a potential new target for the treatment of pancreatic cancer.

3 Feb 2022

Physical exercise increases synaptic resilience against age-related neuropathologies

Researchers from the UPV/EHU's Department of Pharmacology and the CIBER Mental Health network are taking part in a study published in the latest issue of the prestigious journal Alzheimer's & Dementia; it sheds light on the biological processes that mediate the beneficial effect of physical exercise on cognitive skills and mental health.

3 Feb 2022

NIAID's new pandemic preparedness efforts aim to characterize prototype and priority pathogens

As the global COVID-19 pandemic continues into its third year, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is focusing on preparing for a range of other viral threats that could cause a public health emergency.

2 Feb 2022

Assessing an intranasal lentiviral booster against COVID-19 variants

A new study explores the possibility of vaccination via nasal route utilizing a lentiviral vaccination vector (LV) to be administered as a booster dose against COVID-19.

2 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

New RNA therapies for the treatment of heart failure and organ fibrosis

RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic approaches.

1 Feb 2022

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

It is estimated that more than 100 million U.S. adults are affected by chronic pain, a condition that annually costs the country an estimated $560-635 billion in health care costs, disability and lost productivity.

1 Feb 2022

Zika virus vaccine candidate found to be safe and effective in preclinical animal studies

A Zika virus vaccine candidate is effective at preventing the Zika virus passing from mother to fetus in preclinical animal studies, according to a new study in the journal npj Vaccines.

1 Feb 2022

Researchers develop new technique to open the blood-brain barrier in lab animals

University of Maryland School of Medicine researchers developed a technique in laboratory animals to consistently and reproducibly open the blood-brain barrier.

31 Jan 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Study identifies drugs that could help combat mortality in patients with COVID-19

Inflammation is a defense mechanism of the body to fight pathogens. However, when it is widespread and excessive, it can aggravate the pathology and even cause death.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

Preclinical News and Research

Roswell Park scientists identify a potential new treatment target for pancreatic cancer

Physical exercise increases synaptic resilience against age-related neuropathologies

NIAID's new pandemic preparedness efforts aim to characterize prototype and priority pathogens

Assessing an intranasal lentiviral booster against COVID-19 variants

Nanomedicine can be improved with proper and more predictive in vitro assays

New RNA therapies for the treatment of heart failure and organ fibrosis

TTUHSC project awarded new NIH grant to advance research on amygdala pain mechanisms

Zika virus vaccine candidate found to be safe and effective in preclinical animal studies

Researchers develop new technique to open the blood-brain barrier in lab animals

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Study identifies drugs that could help combat mortality in patients with COVID-19

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Research shows minks mimic severe COVID-19 symptoms, including ARDS

USC’s new center aims to address unmet needs in neurodegenerative diseases of the eye and brain

Study investigates how vitamin D or omega fatty acids may affect rates of autoimmune diseases

Hyaluronic acid acts as food to pancreatic cancer cells, study shows

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

Broad and potent neutralizing activity of human IgG1 LALA antibody against SARS-CoV-2 variants

Novel gene therapy for diseased muscle fiber repair

Single type of neuron found to be responsible for keeping our legs in lockstep

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