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Yale researchers identify multiple genes involved in suppression of axon regeneration

When central nervous system cells in the brain and spine are damaged by disease or injury, they fail to regenerate, limiting the body's ability to recover.

2 Mar 2021

SARS-CoV-2 UK variant shows low virulence and high shedding in hamster model

A new study compares the pathogenicity and infectiousness of one such variant, the VOC 202012/01 (B.1.1.7 lineage) from the United Kingdom, with the globally dominant D614G mutation-carrying strains.

2 Mar 2021

CN Bio awarded Innovate UK grant to develop single and multi-organ models for COVID-19 research

CN Bio today announced it has received a grant from Innovate UK to develop human-relevant MPS to advance investigations into SARS-CoV-2 infection.

From CN Bio 2 Mar 2021

Researchers discover new ingredient that has protective effects against Parkinson’s disease

Sesame seed oil, used by many for its nutty aroma and high burn-point, is made by extracting the fatty oils from sesame seeds, with the empty shells thrown out as waste. In a literal instantiation of the age-old adage "one man's trash is another man's treasure", researchers discovered that a chemical called sesaminol, abundant in this waste, has protective effects against Parkinson's disease.

2 Mar 2021

Unique nanoparticles can package and deliver gene-editing machinery to the liver

The genome editing technology CRISPR has emerged as a powerful new tool that can change the way we treat disease. The challenge when altering the genetics of our cells, however, is how to do it safely, effectively, and specifically targeted to the gene, tissue and organ that needs treatment.

2 Mar 2021

Scientists establish infection models for SARS-CoV-2 UK & South African variants

New research suggests Syrian golden hamsters could be a potentially useful preclinical model for testing vaccine immunity against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.17 and B.1.351 variant.

1 Mar 2021

Study shows how D614G variant gains upper hand over original SARS-CoV-2 virus

Prior to the emergence of new mutants of the coronavirus, such as the British variant B.1.1.7, the SARS-CoV-2 variant named D614G had already mutated from the original SARS-CoV-2 pathogen that triggered the pandemic.

27 Feb 2021

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

The Innovation Center of NanoMedicine (Director General: Prof. Kazunori Kataoka, Location: Kawasaki in Japan, Abbreviation: iCONM) reported in ACS Nano (Impact Factor: 14.588 in 2019) together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery (Prof. Tatsuya Yamasoba) and the group of Prof. Horacio Cabral of the Department of Bioengineering (Prof. Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene, has been developed.

27 Feb 2021

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Curcumin is a polyphenol compound produced by plants of the Curcuma longa species and has been reported to have many physiological activities, which include anti-oxidation, anti-inflammatory, anti-cancer, and anti-amyloid properties.

27 Feb 2021

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Researchers have developed a stable and ultrapotent homotrimeric Pittsburgh inhalable Nanobody 21 (PiN-21) against SARS-CoV-2 infection in Syrian hamsters. They demonstrated the high therapeutic efficacy of this homotrimeric Nb, leveraging both intranasal and aerosol delivery.

26 Feb 2021

Scientists receive grant to investigate tumor development within a natural environment

Unlike many of us during the COVID-19 pandemic, biological cells are not isolated from the outside world. Chemical variations, intercellular activity, and other microenvironmental factors impact cell survival.

25 Feb 2021

Study pinpoints potential transmission advantage of SARS-CoV-2 variant B.1.1.7

Researchers in the UK have shown that the increased transmissibility of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.1.7 that emerged in the UK during the coronavirus disease 2019 (COVID-19) pandemic does not appear to be the result of increased viral replication or immune escape.

25 Feb 2021

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ("AI") and drug discovery -- linking together generative chemistry and biology for the first time -- to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ("IPF") and be validated with multiple human cell and animal model experiments.

25 Feb 2021

In Vivo Probes for Detecting Inflammation Markers in Humans and Animals

News-Medical talks to Parry Hashemi about research on in vivo probes for detecting inflammation markers in humans and animals she will present at Pittcon.

From Pittcon 24 Feb 2021

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

A team of researchers examined PT150, which is an allosteric modulator of androgen and glucocorticoid receptors, to assess whether it had any antiviral activity or immunomodulatory activity to decrease the hyperinflammatory response of SARS-CoV-2 infection.

24 Feb 2021

New glioma-targeted nano-therapeutic offers a potential treatment for glioblastomas

With a survival rate of only five years, the most common and aggressive form of primary brain tumor, glioblastoma multiforme, is notoriously hard to treat using current regimens that rely on surgery, radiation, chemotherapy, and their combinations.

24 Feb 2021

Research predicts which mammal species can spread SARS-CoV-2

Scientists worldwide are fighting to contain the ongoing COVID-19 pandemic, which has already claimed more than 2.48 million lives. Preventing spillback infections is essential to containing the pandemic. To do so, it is vital to understand the nature of the virus, i.e., its susceptibility to a range of hosts.

23 Feb 2021

in vivo News and Research

Yale researchers identify multiple genes involved in suppression of axon regeneration

SARS-CoV-2 UK variant shows low virulence and high shedding in hamster model

CN Bio awarded Innovate UK grant to develop single and multi-organ models for COVID-19 research

Researchers discover new ingredient that has protective effects against Parkinson’s disease

Unique nanoparticles can package and deliver gene-editing machinery to the liver

Scientists establish infection models for SARS-CoV-2 UK & South African variants

Study shows how D614G variant gains upper hand over original SARS-CoV-2 virus

Efficacy of polymeric nano-micelles depends on expression level of c-Myc

Study demonstrates the novel agonistic effect of curcumin on lipid transcription

Inhalable nanobody shows potent anti-SARS-CoV-2 activity in vivo

Scientists receive grant to investigate tumor development within a natural environment

Study pinpoints potential transmission advantage of SARS-CoV-2 variant B.1.1.7

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

In Vivo Probes for Detecting Inflammation Markers in Humans and Animals

Corticosteroid receptor inhibitor shows anti-SARS-CoV-2 activity in vivo

New glioma-targeted nano-therapeutic offers a potential treatment for glioblastomas

Research predicts which mammal species can spread SARS-CoV-2

Researchers study how seasons influence the brain function

Could rotavirus vaccine platforms aid in the immunization campaign against SARS-CoV-2?

Maturation of 'mini brain' organoids matches human brain development

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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