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Researchers discover potential new way to target pancreatic tumors with high IFN signaling

UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN).

18 Feb 2021

Clinical trial launched to analyze bovine-derived immunoglobulins for preventing COVID-19 side effects

The Hospital del Mar Medical Research Institute (IMIM), Hospital del Mar, the University of California-Davis and the University of Texas have launched a clinical trial to analyze how useful a food supplement can be for preventing the worst side effects of COVID-19.

18 Feb 2021

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

A team of scientists from Australia and Brazil recently investigated the involvement of endothelial cells in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Feb 2021

Mice study finds altered brain connectivity after prolonged anesthesia

Prolonged anesthesia, also known as medically induced coma, is a life-saving procedure carried out across the globe on millions of patients in intensive medical care units every year.

17 Feb 2021

Researchers develop new tool for tackling disseminated intravascular coagulation

Researchers have developed a new tool for addressing disseminated intravascular coagulation (DIC) - a blood disorder that proves fatal in many patients.

17 Feb 2021

Researchers develop a better solution to treat short bowel syndrome

Short Bowel Syndrome (SBS) is a medical disorder caused by a lack of a fully functional small intestine.

17 Feb 2021

Nanobodies protect against SARS-CoV-2 variants in animal model

Nanobodies are a potential therapeutic strategy for treating COVID-19. While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration.

15 Feb 2021

New mouse model of SARS-CoV-2 infection reflects features of human infection

Now, a new preprint research paper posted to the bioRxiv server reports the development of a modified mouse model that allows productive SARS-CoV-2 infection of the mouse lungs, as well as the exploration of type I and III interferon responses in this condition.

14 Feb 2021

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

Researchers from Cuba, China, and France have demonstrated the potential of coupling a viral antigen with the tetanus toxoid protein as a vaccination approach to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

14 Feb 2021

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice.

11 Feb 2021

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

Publishing their work in Nature, scientists at the UNC School of Medicine and UNC Gillings School of Global Public Health found that the orally administered experimental drug EIDD-2801 halts SARS-CoV-2 replication and prevents infection of human cells in a new in vivo lab model containing human lung tissue.

10 Feb 2021

Traumatic or stressful events in childhood may lead to changes in key brain structures

A new study from University of Alberta researchers has shown that traumatic or stressful events in childhood may lead to tiny changes in key brain structures that can now be identified decades later.

9 Feb 2021

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Although SGLT-2 inhibitors are central to the treatment of diabetes, their exact mode of action was hitherto unknown.

8 Feb 2021

Bernese researchers develop a second generation lung-on-chip

The lung is a complex organ whose main function is to exchange gases. It is the largest organ in the human body and plays a key role in the oxygenation of all the organs.

8 Feb 2021

Novel hybrid device to boost research on metastatic process of breast cancer cells

European researchers are working on a novel hybrid device to better understand the metastatic process of cancer cells travelling from breast to bone and fast screen new drugs against it.

6 Feb 2021

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Senescent cells accumulate in organs during aging, promote tissue dysfunction, and cause numerous aging-related diseases like cancer. The cells arise through a process called "cellular senescence," a permanent cell cycle arrest resulting from multiple stresses.

5 Feb 2021

Imaging technique can differentiate Alzheimer's disease from dementia with Lewy bodies

Scientists in Portugal and the United Kingdom were able to confirm that an imaging technique that traces neuronal dopaminergic deficiency in the brain is able to differentiate, in vivo, Alzheimer's disease from lesser-known dementia with Lewy bodies.

5 Feb 2021

Finding ways to relieve painful intercourse

Researchers at Flinders University are working to remedy this situation by identifying what triggers this chronic pain in the female reproductive tract.

4 Feb 2021

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

A new study server reports highly protective neutralizing monoclonal antibodies against the SARS-CoV-2.

4 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

in vivo News and Research

Researchers discover potential new way to target pancreatic tumors with high IFN signaling

Clinical trial launched to analyze bovine-derived immunoglobulins for preventing COVID-19 side effects

Endothelial SARS-CoV-2 infection induces proinflammatory responses without supporting viral amplification, finds study

Mice study finds altered brain connectivity after prolonged anesthesia

Researchers develop new tool for tackling disseminated intravascular coagulation

Researchers develop a better solution to treat short bowel syndrome

Nanobodies protect against SARS-CoV-2 variants in animal model

New mouse model of SARS-CoV-2 infection reflects features of human infection

Vaccine candidate containing tetanus toxoid potentially protective against SARS-CoV-2

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

Traumatic or stressful events in childhood may lead to changes in key brain structures

Study elucidates the mode of action of SGLT2 inhibitors in diabetes

Bernese researchers develop a second generation lung-on-chip

Novel hybrid device to boost research on metastatic process of breast cancer cells

GLS1 inhibitor selectively eliminates senescent cells, ameliorates age-associated disorders

Imaging technique can differentiate Alzheimer's disease from dementia with Lewy bodies

Finding ways to relieve painful intercourse

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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