Genetic News and Research

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rEVO Biologics commences ATryn Phase 3 clinical program for treatment of preeclampsia in pregnant women

rEVO Biologics Inc., a subsidiary of LFB SA, today announced the initiation of the Phase 3 clinical program for ATryn for the treatment of preeclampsia in pregnant women during the 24th to 28th week of pregnancy.

31 Mar 2014

Amgen reports positive findings from AMG 145 Phase 3 studies in patients at risk for cardiovascular disease

Amgen (NASDAQ: AMGN) today announced new detailed data from three Phase 3 studies that showed treatment with its novel investigational cholesterol-lowering medication, evolocumab (AMG 145), resulted in a statistically significant reduction of 55-66 percent in low-density lipoprotein cholesterol (LDL-C) compared to placebo in patients with high cholesterol.

31 Mar 2014

Genetic markers could help predict heart attack in patients with heart disease

Researchers at the Intermountain Medical Center Heart Institute in Salt Lake City have identified a biological process that may help physicians predict when someone with heart disease is likely to have a heart attack in the near future.

31 Mar 2014

International scientists identify novel genetic defects that induce oesophageal cancer

A team of scientists from the Cancer Science Institute of Singapore at the National University of Singapore and National University Cancer Institute Singapore, and their collaborators from the Cedars-Sinai Medical Centre, UCLA School of Medicine, demonstrated that a number of novel genetic defects are able to induce oesophageal cancer.

31 Mar 2014

New gene-editing system holds potential for treating many genetic disorders

Using a new gene-editing system based on bacterial proteins, MIT researchers have cured mice of a rare liver disorder caused by a single genetic mutation.

31 Mar 2014

Carb breakdown gene linked to obesity, researchers find

Researchers at King's College London and Imperial College London have discovered that people with fewer copies of a gene coding for a carb-digesting enzyme may be at higher risk of obesity. The findings, published in Nature Genetics, suggest that dietary advice may need to be more tailored to an individual's digestive system, based on whether they have the genetic predisposition and necessary enzymes to digest different foods.

31 Mar 2014

New high-risk cancer causing mutation identified for melanoma development

Researchers have discovered that mutations in a specific gene are responsible for a hereditary form of melanoma.

31 Mar 2014

Whole-genome sequencing in newborns could help detect, manage wide array of disorders

Should whole-genome sequencing be used in the public-health programs that screen newborns for rare conditions?

29 Mar 2014

Johns Hopkins neuroscientists identify cause of brain degeneration in Huntington's disease

Working with genetically engineered mice, Johns Hopkins neuroscientists report they have identified what they believe is the cause of the vast disintegration of a part of the brain called the corpus striatum in rodents and people with Huntington's disease: loss of the ability to make the amino acid cysteine.

29 Mar 2014

Genetic variations influence risk for developing choline deficiency symptoms

What is now considered to be the "right" amount of the essential nutrient, choline, might actually be "wrong," depending on who you are. That's because scientists have found that the "right" amount of choline needed by an individual is influenced by a wide range of factors, including gender, life stage, race and ethnicity of the individual.

29 Mar 2014

Certain inherited DNA sequences may affect prognosis of bladder cancer patients

While patients diagnosed with bladder cancer usually face a favorable prognosis, many experience recurrence after treatment. Because frequent, painful screenings are needed to identify recurrences, the ablility to identify patients at high risk of recurrent cancer could help to improve quality of life for all bladder cancer patients.

29 Mar 2014

Findings underscore importance of universal pediatric cholesterol screening

Roughly one out of three kids screened for high cholesterol between the ages of 9 and 11 has borderline or high cholesterol, potentially placing them at greater risk for future cardiovascular disease, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session.

29 Mar 2014

Two pediatricians win March of Dimes/Col. Harland D. Sanders Lifetime Achievement Award in Genetics

Two pediatricians whose research led to the need for early identification of and treatment of severe combined immunodeficiency (SCID) and its inclusion in newborn screening have received the March of Dimes/Col. Harland D. Sanders Lifetime Achievement Award in Genetics.

29 Mar 2014

Elsevier launches open access journal addressing role of cognitive functioning in schizophrenia

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the launch of Schizophrenia Research: Cognition, a new open access journal dedicated to publishing original research, concise research reports, brief reports, letters to the editor, and review papers addressing the role of cognitive functioning in schizophrenia.

28 Mar 2014

Researchers find new drug target for mitochondrial dysfunction

Mitochondria, long known as "cellular power plants" for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer's disease, and Parkinson's disease, and are the hallmarks of a number of genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure. Despite a fairly strong understanding of the pathology of such genetic mitochondrial disorders, efforts to treat them have been largely ineffective.

28 Mar 2014

Research findings help explain rare genetic disorder that causes immunodeficiency syndrome

IRCM researchers led by Javier M. Di Noia, PhD, uncovered a new function of AID, a crucial enzyme for the immune response. The discovery, recently published by the scientific journal Proceedings of the National Academy of Sciences, helps explain a rare genetic disorder that causes an immunodeficiency syndrome.

28 Mar 2014

Genetic News and Research

rEVO Biologics commences ATryn Phase 3 clinical program for treatment of preeclampsia in pregnant women

Amgen reports positive findings from AMG 145 Phase 3 studies in patients at risk for cardiovascular disease

Genetic markers could help predict heart attack in patients with heart disease

International scientists identify novel genetic defects that induce oesophageal cancer

New gene-editing system holds potential for treating many genetic disorders

Carb breakdown gene linked to obesity, researchers find

New high-risk cancer causing mutation identified for melanoma development

Whole-genome sequencing in newborns could help detect, manage wide array of disorders

Johns Hopkins neuroscientists identify cause of brain degeneration in Huntington's disease

Genetic variations influence risk for developing choline deficiency symptoms

Certain inherited DNA sequences may affect prognosis of bladder cancer patients

Findings underscore importance of universal pediatric cholesterol screening

Two pediatricians win March of Dimes/Col. Harland D. Sanders Lifetime Achievement Award in Genetics

Elsevier launches open access journal addressing role of cognitive functioning in schizophrenia

Researchers find new drug target for mitochondrial dysfunction

Research findings help explain rare genetic disorder that causes immunodeficiency syndrome

Tgen professor to receive 2014 Hope Funds Award for developing numerous cancer treatments

Tumor suppressor gene linked to stem cell function

Schizophrenia Research: Cognition, an online open access journal from Elsevier

Research points strong reason to develop new class of antidepressant drug

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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