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Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide.

15 Apr 2025

Researchers develop drug cocktail to target enteroviruses

Enteroviruses are a group of viruses that cause everything from the common cold to meningitis, polio, type 1 diabetes, and much more. Over 100 different types have been described by researchers, and millions of people are infected each year.

15 Apr 2025

Discovery of special dendritic cells sheds light on food allergy prevention

The immune system must be able to quickly attack invaders like viruses, while also ignoring harmless stimuli, or allergies can result. Immune cells are known to ignore or "tolerate" molecules found on the body's own healthy cells, for instance, as well as nonthreatening substances from outside the body like food.

15 Apr 2025

Inherited genetic variants play crucial role in cancer development and behavior

A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the National Cancer Institute-funded Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the genes we are born with-known as germline genetic variants-play a powerful, underappreciated role in how cancer develops and behaves.

15 Apr 2025

Inherited mutations in healthy cells may contribute to cancer development

Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked.

15 Apr 2025

MGI tech celebrates 10 years of DNBSEQ™ technology: driving genomics forward with speed, scale, and accessibility

MGI's DNBSEQ™ technology redefines genomics, delivering exceptional sequencing performance and enabling multi-omics applications for diverse scientific fields.

From MGI 15 Apr 2025

Lithium shifts circadian rhythms early in bipolar disorder and may offer clues to treatment response

A randomized controlled trial shows that lithium treatment in bipolar disorder patients reduces daytime activity, advances its onset time, and increases volatility in circadian rest-activity patterns. These changes appear early and independently of mood, offering promise as early biomarkers of treatment response.

14 Apr 2025

Why measles is back in the U.S. and what doctors must know now

Measles is making a troubling comeback in the U.S., driven by declining vaccination rates and rising vaccine hesitancy. Pediatric infectious disease experts provide clinical guidance to help healthcare providers recognize, manage, and prevent measles in today’s outbreak-prone environment.

14 Apr 2025

Selective depletion of PD-1 positive lymphocytes using a novel bispecific killer engager

This new article publication from Acta Pharmaceutica Sinica B, discusses a bispecific killer engager for targeted depletion of PD-1 positive lymphocytes.

14 Apr 2025

Food pantries uncover hidden diabetes crisis in West Chicago

A screening initiative in West Chicago found that 50% of food-insecure individuals had abnormal A1c levels, with many unaware they were diabetic or prediabetic. The findings highlight a critical gap in diagnosis and control among underserved communities.

13 Apr 2025

New study connects parasitic disease to genetic changes in the cervical lining

New research has revealed that Schistosoma haematobium (S. haematobium), a parasitic infection affecting millions globally, can trigger cancer-related gene activity in the cervical lining, with changes becoming even more pronounced after treatment.

12 Apr 2025

Psychologists explore ethical issues associated with human-AI relationships

It's becoming increasingly commonplace for people to develop intimate, long-term relationships with artificial intelligence (AI) technologies.

11 Apr 2025

Northwestern scientists identify key genes behind Parkinson's development

A longstanding mystery in Parkinson's disease research has been why some individuals carrying pathogenic variants that increase their risk of PD go on to develop the disease, while others who also carry such variants do not.

11 Apr 2025

Boosting tumor-infiltrating lymphocyte therapy with the power of B cells

Researchers at Moffitt Cancer Center have found that tapping into the body's own immune system and activating a type of immune cell known as B cells, could be the key to boosting the effectiveness of tumor-infiltrating lymphocyte, or TIL therapy.

11 Apr 2025

Understanding the complex spectrum of Castleman disease

Castleman disease (CD) is a rare, non-clonal lymphoproliferative disorder that manifests with a wide range of histologic and clinical features.

11 Apr 2025

Bacteria engineered for remote sensing through color signatures

Bacteria can be engineered to sense a variety of molecules, such as pollutants or soil nutrients. In most cases, however, these signals can only be detected by looking at the cells under a microscope or similarly sensitive lab equipment, making them impractical for large-scale use.

11 Apr 2025

COVID-19 treatments show minimal serious side effects

Numerous treatment options for COVID-19 have been approved by the U.S. Food and Drug Administration over the last four years, including antiviral drugs and monoclonal antibodies that suppress an excessive immune response.

11 Apr 2025

GSK3β identified as a driver of drug resistance in BRAF mutant melanoma

A new research perspective was published in Oncotarget, Volume 16, on April 4, 2025, titled "GSK3β activation is a key driver of resistance to Raf inhibition in BRAF mutant melanoma cells."

11 Apr 2025

New blood test method improves accuracy of cancer detection

A new, error-corrected method for detecting cancer from blood samples is much more sensitive and accurate than prior methods and may be useful for monitoring disease status in patients following treatment, according to a study by Weill Cornell Medicine and New York Genome Center investigators.

11 Apr 2025