Clinical Trial News and Research

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Clinigen launches 'What is Possible?' campaign to expand access to rare disease treatments

Clinigen, the global pharmaceutical services company, today launched a new campaign called ‘What is Possible?’ to help empower patients and medical professionals to ask what more is possible in the treatment of rare diseases.

4 Mar 2024

Microbial signatures linked to immunotherapy response across cancers

The microbiome can identify those who benefit from combination immunotherapy across multiple different cancers, including rare gynecological cancers, biliary tract cancers and melanoma.

1 Mar 2024

SickKids study offers new path for pediatric rare disease clinical trials

Using a novel methodology, researchers at The Hospital for Sick Children (SickKids) are the first in pediatric research to use data from an international real-world cohort to overcome the barriers associated with conducting randomized clinical trials in children with rare diseases.

29 Feb 2024

Consistent Evidence Links Ultra-Processed Food To Over 30 Damaging Health Outcomes

Consistent evidence shows that higher exposure to ultra-processed foods is associated with an increased risk of 32 damaging health outcomes including cancer, major heart and lung conditions, mental health disorders, and early death.

29 Feb 2024

New approach detects T cells in "cold" tumors, paves way for broader immunotherapy

Most cancers are thought to evade the immune system. These cancers don't carry very many mutations, and they aren't infiltrated by cancer-fighting immune cells. Scientists call these cancers immunologically "cold."

29 Feb 2024

Novel drug combination shows promise for treating advanced skin cancers in kidney transplant recipients

People who have had a kidney transplant are at high risk for developing skin cancers. New research directed by investigators from the Johns Hopkins Kimmel Cancer Center is exploring the best combination of treatments to target skin cancers while preserving the transplanted organs.

28 Feb 2024

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement – recombinant human insulin-like growth factor 1 and its binding protein-3 (rhIGF-1/BP3) – protected neonatal mice from necrotizing enterocolitis (NEC), a deadly intestinal disease that often strikes extremely premature infants.

28 Feb 2024

Bio-Hermes data reveals strong correlation between blood biomarkers and Alzheimer's amyloid plaques

The Global Alzheimer's Platform Foundation, (GAP) is releasing the first results from the Bio-Hermes-001 Study.

28 Feb 2024

New blood biomarkers identified to predict cardiovascular risk in rheumatoid arthritis patients

Rheumatoid arthritis impacts approximately 2 million people in the United States and is associated with increased risk of cardiovascular disease.

28 Feb 2024

Resistant starch diet proves a game changer for weight loss and diabetes control

Supplementation with resistant starch leads to weight loss and improved insulin sensitivity by altering the gut microbiome and increasing secondary bile acids, according to a recent study in Nature Metabolism.

27 Feb 2024

FB1006: AI-discovered drug advances to clinical trials for ALS treatment

Amyotrophic Lateral Sclerosis (ALS) is a fatal type of motor neuron disease characterized by progressive degeneration of nerve cells in the spinal cord and brain, resulting in muscle weakness and paralysis that can include the inability to walk and speak, or even swallow and breathe.

27 Feb 2024

Cognitive behavioral therapy helps prevent postpartum mental health challenges in low-resource settings

Results from a large clinical trial funded by the National Institutes of Health show that an intervention for anxiety provided to pregnant women living in Pakistan significantly reduced the likelihood of the women developing moderate-to-severe anxiety, depression, or both six weeks after birth.

26 Feb 2024

Glitazone drug use by diabetic patients associated with lower risk of primary and secondary brain cancer

Diabetic patients who take anti-diabetic drugs - known as glitazones - long term had a lower risk of primary and secondary brain cancer compared with diabetic patients on other medications, new research led by the University of Bristol has found.

26 Feb 2024

Study: Antibody combination shows safety and anti-tumor activity in advanced cancer patients

In an early phase clinical trial, a combination of antibody-based medications targeting the immune system generated promising safety data and anti-tumor activity in individuals with various types of advanced cancer.

26 Feb 2024

Fish oil in pregnancy linked to child weight gain and metabolic risks

A study in The American Journal of Clinical Nutrition finds that fish oil supplementation during pregnancy is linked to increased risk of weight gain and metabolic syndrome in offspring at age ten.

25 Feb 2024

Omalizumab shows promise in preventing food allergy reactions in children, study finds

A drug can make life safer for children with food allergies by preventing dangerous allergic responses to small quantities of allergy-triggering foods, according to a new study led by scientists at the Stanford School of Medicine.

25 Feb 2024

Researchers identify new therapeutic for patients with a rare autoimmune disease EGPA

An international team, including researchers from McMaster University and St. Joseph's Healthcare Hamilton, has identified a new therapeutic for patients with a rare autoimmune disease called eosinophilic granulomatosis with polyangiitis (EGPA).

24 Feb 2024

Global health boost as new vaccine SKYTyphoid gains WHO prequalification

SK bioscience and the International Vaccine Institute (IVI) announced today that the typhoid conjugate vaccine developed by SK bioscience with technology transfer from IVI has achieved the World Health Organization prequalification (PQ), which paves the way for public procurement of the vaccine by UN organizations and gives a boost to the global TCV supply.

23 Feb 2024

Off-the-shelf cancer vaccine shows promising results in patients with KRAS-mutated tumors

Samara Rahman, 74, considers herself lucky. She gets to take walks on the beach, go swimming and ride her bike - all things that were taken from her when she was diagnosed with pancreatic cancer in November of 2022.

22 Feb 2024

Study: Early advanced therapy significantly improves Crohn's disease outcomes

A large-scale clinical trial of treatment strategies for Crohn's disease has shown that offering early advanced therapy to all patients straight after diagnosis can drastically improve outcomes, including by reducing the number of people requiring urgent abdominal surgery for treatment of their disease by ten-fold.

22 Feb 2024

Clinical Trial News and Research

Clinigen launches 'What is Possible?' campaign to expand access to rare disease treatments

Microbial signatures linked to immunotherapy response across cancers

SickKids study offers new path for pediatric rare disease clinical trials

Consistent Evidence Links Ultra-Processed Food To Over 30 Damaging Health Outcomes

New approach detects T cells in "cold" tumors, paves way for broader immunotherapy

Novel drug combination shows promise for treating advanced skin cancers in kidney transplant recipients

Investigational protein replacement protects neonatal mice from deadly intestinal disease

Bio-Hermes data reveals strong correlation between blood biomarkers and Alzheimer's amyloid plaques

New blood biomarkers identified to predict cardiovascular risk in rheumatoid arthritis patients

Resistant starch diet proves a game changer for weight loss and diabetes control

FB1006: AI-discovered drug advances to clinical trials for ALS treatment

Cognitive behavioral therapy helps prevent postpartum mental health challenges in low-resource settings

Glitazone drug use by diabetic patients associated with lower risk of primary and secondary brain cancer

Study: Antibody combination shows safety and anti-tumor activity in advanced cancer patients

Fish oil in pregnancy linked to child weight gain and metabolic risks

Omalizumab shows promise in preventing food allergy reactions in children, study finds

Researchers identify new therapeutic for patients with a rare autoimmune disease EGPA

Global health boost as new vaccine SKYTyphoid gains WHO prequalification

Off-the-shelf cancer vaccine shows promising results in patients with KRAS-mutated tumors

Study: Early advanced therapy significantly improves Crohn's disease outcomes

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