Genetic Information News and Research

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Expert cautions against rushing into genetic testing

Just because scientific advances now allow individuals to learn their genetic make-up doesn't mean they should rush into genetic testing in hopes of making revolutionary improvements to their health, cautions a geneticist and practicing physician at the University of North Carolina at Chapel Hill.

1 Jun 2008

Spontaneous mutations widespread in non-familial schizophrenia

People with schizophrenia from families with no history of the illness were found to harbor eight times more spontaneous mutations - most in pathways affecting brain development - than healthy controls, in a study supported in part the National Institutes of Health?s (NIH) National Institute of Mental Health (NIMH). By contrast, no spontaneous mutations were found in people with schizophrenia who had family histories of the illness.

30 May 2008

Estrogen drives distinct, aggressive prostate cancer

Using a breakthrough technology, researchers led by a Weill Cornell Medical College scientist have pinpointed the hormone estrogen as a key player in about half of all prostate cancers.

28 May 2008

Clockwork PCR including sample prep

Analysis and diagnosis in a chip format are coming of age, but their practical application has been limited because until now, the sample usually had to be prepared separately and on a nonminiaturized scale.

6 May 2008

Whole-organ genomic survey depicts journey from normal to malignant cell

Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation.

5 May 2008

U.S. Congress passes genetic nondiscrimination act

The U.S. House of Representatives passed the Genetic Information Nondiscrimination Act (GINA) today by a vote of 414-1, building on the momentum of last week's unanimous Senate vote.

1 May 2008

Scientists solve mystery about critical mechanism of gene expression

Although letters representing the three billion pairs of molecules that form the "rungs" of the helical DNA "ladder" are routinely called the human "genetic code," the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the code.

22 Apr 2008

TOR signaling and dietary restriction

University of Washington scientists have uncovered details about the mechanisms through which dietary restriction slows the aging process.

17 Apr 2008

Computational approaches to the role of epigenetic marks in transcription regulation

A closer alliance between computational and experimental researchers is needed to make progress towards one of biology's most challenging goals, understanding how epigenetic marks contribute to regulation of gene expression.

11 Apr 2008

miRNAs can control the fertility of female mice

Small molecules known as miRNAs, which are generated naturally by the body, regulate the conversion of genetic information into proteins.

9 Apr 2008

New potential approach to treat spinal muscular atrophy

In the neuromuscular disease called spinal muscular atrophy, or SMA, a protein deficiency caused by a single gene mutation leads to serious damage in growing nerve cells and the muscles they control.

7 Apr 2008

Answer to troublesome question of why some genetic assoc. studies have failed replication attempts

A team of researchers from Harvard School of Public Health (HSPH), Brigham and Women's Hospital (BWH), and elsewhere have described a possible reason why some studies have been unable to replicate associations between genes and traits -- namely that the strength of a gene/trait association might vary with age and that current study designs typically fail to take that into account.

4 Apr 2008

11 "snips" associated with type 2 diabetes

Mathematicians at Michigan Technological University have developed powerful new tools for winnowing out the genes behind some of humanity's most intractable diseases.

2 Apr 2008

New genetic clues to diabetes

An international team that included scientists from the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), today reported it has identified six more genetic variants involved in type 2 diabetes, boosting to 16 the total number of genetic risk factors associated with increased risk of the disease.

1 Apr 2008