Preclinical News and Research

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Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

The Wistar Institute announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.

5 Jan 2022

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

New study results suggest that integrin inhibitors have the potential to both prevent infection with SARS-CoV-2, including the Delta and Omicron variants, and to decrease TGF-β levels, resulting in a decrease in COVID-19 severity, hospitalization, and death, especially in vulnerable and unvaccinated populations.

5 Jan 2022

Unique nanoparticle can deliver genome editing technology to endothelial cells

The lab of Youyang Zhao, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls.

4 Jan 2022

Birth during the pandemic associated with slightly lower scores in infants' motor and social skills

Columbia researchers found that babies born during the pandemic's first year scored lower on a developmental screening test of social and motor skills at 6 months - regardless of whether their mothers had COVID during pregnancy - compared to babies born just before the pandemic.

4 Jan 2022

A closer look at the relationship between COVID-19 and Alzheimer’s disease

Researchers discuss the findings of previous studies on the role of SARS-CoV-2 infection in the progression of Alzheimer's Disease.

4 Jan 2022

COVID-19 tests with the new assay may be just as reliable as laboratory-based molecular tests

Researchers at the University of Illinois Chicago have designed a high-quality assay that can be used in at-home tests for rapid COVID-19 screening.

3 Jan 2022

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Researchers investigate the ability of immunity acquired from SARS-CoV-2 wild-type infection to protect against the Omicron variant in Syrian hamster models.

3 Jan 2022

Impact of a pan-sarbecovirus dendritic-cell targeting vaccine on SARS-CoV-2 variants

A new study used in silico approaches for designing a next-generation CD40-targeting vaccine, CD40.

31 Dec 2021

Microgravity likely to contribute to life-saving stem cell advances on Earth

The secret to producing large batches of stem cells more efficiently may lie in the near-zero gravity conditions of space. Scientists at Cedars-Sinai have found that microgravity has the potential to contribute to life-saving advances on Earth by facilitating the rapid mass production of stem cells.

30 Dec 2021

Combination of rifampicin and resveratrol helps stop dementia, finds study

Dementia is thought to occur when proteins called amyloid-β, tau, and α-synuclein accumulate in the brain and form oligomers. A research group from the Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, had previously shown in a study using mice that the antibiotic rifampicin removes oligomers from the brain and improves cognitive function.

29 Dec 2021

High-fiber diet helps melanoma patients to respond better to immunotherapy

Melanoma patients receiving therapy that makes it easier for their immune system to kill cancer cells respond to treatment better when their diet is rich in fiber, according to a large, international research collaboration that includes the Oregon State University College of Pharmacy.

24 Dec 2021

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

Dietary fiber and probiotics impact gut bacteria and immunotherapy responses in melanoma patients, a new study in patients shows.

24 Dec 2021

New insights into how red meat-rich diet increases cardiovascular disease risk

A Cleveland Clinic-led study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease. The findings were published in Nature Microbiology and build on more than a decade of research by lead author Stanley Hazen, MD, PhD.

23 Dec 2021

INTEGRA supports groundbreaking brain tumor research

INTEGRA Biosciences is proud to be supporting vital translational research into diffuse intrinsic ponsglioma (DIPG) – a rare childhood brain tumor – at the Ludwig Maximilian University of Munich (LMU) with a festive donation of 20,000 EUR.

From INTEGRA Biosciences 21 Dec 2021

Seda announces £4m investment in new state-of-the-art facilities

With huge growth in demand for its services, Seda has acquired a new property and is on track to double its annual turnover to at least £7m in the next two years.

From Seda Pharmaceutical Development Services 17 Dec 2021

Race-based formula used to diagnose lung disease should be changed, study suggests

New results from a long-term epidemiologic study reveal that one of the oldest racially based diagnostic formulas in medicine is no better than a race-neutral equation, which suggests the formula used to diagnose lung disease should be changed.

16 Dec 2021

Study provides new insights into molecular drivers of treatment resistance in prostate cancer

An international research team co-led by scientists at Roswell Park Comprehensive Cancer Center and The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute has identified an important accelerator of treatment-resistant prostate cancer.

14 Dec 2021

Preclinical News and Research

Wistar announces initiation of Phase 2 clinical study of VK-2019 in patients with advanced head and neck cancer

Integrin/TGF-β1 inhibitors highly effective in attenuating COVID-19 severity

Unique nanoparticle can deliver genome editing technology to endothelial cells

Birth during the pandemic associated with slightly lower scores in infants' motor and social skills

A closer look at the relationship between COVID-19 and Alzheimer’s disease

COVID-19 tests with the new assay may be just as reliable as laboratory-based molecular tests

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Impact of a pan-sarbecovirus dendritic-cell targeting vaccine on SARS-CoV-2 variants

Microgravity likely to contribute to life-saving stem cell advances on Earth

Combination of rifampicin and resveratrol helps stop dementia, finds study

High-fiber diet helps melanoma patients to respond better to immunotherapy

High-fiber diet linked with improved survival and response to immunotherapy in melanoma patients

New insights into how red meat-rich diet increases cardiovascular disease risk

INTEGRA supports groundbreaking brain tumor research

Seda announces £4m investment in new state-of-the-art facilities

Race-based formula used to diagnose lung disease should be changed, study suggests

Study provides new insights into molecular drivers of treatment resistance in prostate cancer

Duke Human Vaccine Institute secures federal contract for advancing investigational vaccines

Infant immune system beats the adult immune system at fighting off new pathogens

Former diabetes drug may help in the treatment of breast cancer, study shows

Event guide: 4th LNP Formulation & Process Development Summit eBook

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