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Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.

4 Jan 2024

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

A new study published in the journal Diabetes demonstrates that a glucagon-like peptide-1 receptor (GLP-1R) agonist, a member of a class of medication used to treat Type 2 diabetes and obesity, can lead to a rapid improvement in insulin sensitivity.

4 Jan 2024

Salk scientists map brain circuit triggering the crippling panic attacks

Overwhelming fear, sweaty palms, shortness of breath, rapid heart rate - these are the symptoms of a panic attack, which people with panic disorder have frequently and unexpectedly.

4 Jan 2024

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Over the past decades, scientists have made substantial progress unveiling the underlying mechanisms behind many psychiatric disorders.

4 Jan 2024

Combination therapy of dapagliflozin and semaglutide shows superior efficacy in type 2 diabetes management

Study demonstrates that combining dapagliflozin and semaglutide significantly improves glycemic control and other health parameters in type 2 diabetes patients, outperforming dapagliflozin alone.

3 Jan 2024

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

Spicing up the fight: Saffron's powerful impact on prostate cancer revealed

Saffron-treated prostate cancer (PCa) cells.

3 Jan 2024

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

The current achievements in the development of a pan-coronavirus vaccine.

3 Jan 2024

Unlocking the appetite-stimulating secrets of cannabis through rodent brain studies

Study reveals that cannabinoid-1 receptor-expressing neurons in the mediobasal hypothalamus play a key role in the appetite-stimulating effects of inhaled cannabis in rodents, offering insights into potential treatments for anorexia.

2 Jan 2024

Scientists link growth hormone to anxiety and fear memory through specific neuron group

Growth hormone (GH) acts on many tissues throughout the body, helping build bones and muscles, among other functions.

2 Jan 2024

Brain receptor discovery opens door to new therapies for addiction and mental health

Researchers at the Icahn School of Medicine at Mount Sinai have uncovered insights into the potential mechanism of action of the antipsychotic medication asenapine, a possible therapeutic target for substance use and neuropsychiatric disorders.

2 Jan 2024

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.

2 Jan 2024

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

27 Dec 2023

Understanding the genetic basis of hereditary diffuse gastric cancer

Gastric cancer, a significant global health burden, claims over 7% of cancer-related deaths annually. Although only 1-3% of cases have a genetic basis, understanding these genetic drivers is crucial for developing preventative strategies.

26 Dec 2023

Fox urine compound effectively repels flies through multisensory activation

Crop damage in agriculture and the transmission of vector-borne diseases by insect pests have become worldwide threat nowadays.

25 Dec 2023

Microglia found to play a key role in regulating the body's response to anesthesia

Though it may be a surprise to the millions of people who undergo general anesthesia every year for medical procedures, the biological mechanism for how different anesthetics block consciousness is still not fully understood.

22 Dec 2023

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.

22 Dec 2023

Receptor News and Research

Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

GLP-1R agonist liraglutide rapidly improves insulin sensitivity in pre-diabetics, independent of weight loss

Salk scientists map brain circuit triggering the crippling panic attacks

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Combination therapy of dapagliflozin and semaglutide shows superior efficacy in type 2 diabetes management

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

Spicing up the fight: Saffron's powerful impact on prostate cancer revealed

Are pan-coronavirus vaccines an achievable goal in providing broad protection against human coronaviruses?

Unlocking the appetite-stimulating secrets of cannabis through rodent brain studies

Scientists link growth hormone to anxiety and fear memory through specific neuron group

Brain receptor discovery opens door to new therapies for addiction and mental health

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Understanding the genetic basis of hereditary diffuse gastric cancer

Fox urine compound effectively repels flies through multisensory activation

Microglia found to play a key role in regulating the body's response to anesthesia

St. Jude researchers crack the code of the β2-adrenergic receptor

Previously unrecognized class of antibodies can broadly neutralize multiple virus strains

TMDU researchers develop novel method to identify protein-protein binding interfaces

Study reveals cytoglobin's pivotal role in cilia movement and organ positioning during development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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