Central Nervous System News and Research

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CNIO researchers describe presence of MDH2 gene mutations in hereditary neuroendocrine tumors

Researchers in the Hereditary Endocrine Cancer Group of the Spanish National Cancer Research Centre -- led by Alberto Cascón and Mercedes Robledo -- have described the presence of mutations in the MDH2 gene, in a family with very rare neuroendocrine tumours associated with a high hereditary component: pheochromocytomas and paragangliomas that affect the suprarenal and parathyroid glands (groups of chromaffin cells in the central nervous system), respectively.

30 Mar 2015

Researchers present new studies on cognition and reasoning at CNS conference in San Francisco

Even rats can imagine: A new study finds that rats have the ability to link cause and effect such that they can expect, or imagine, something happening even if it isn't.

30 Mar 2015

Experimental drug that attacks brain tumor cells passes early tests

An experimental drug that attacks brain tumor tissue by crippling the cells' energy source called the mitochondria has passed early tests in animal models and human tissue cultures, say Houston Methodist scientists.

25 Mar 2015

Funding helps researchers to kiss MS goodbye

Murdoch University researchers have received funding to investigate the link between the Epstein-Barr virus infection, more commonly known as glandular fever or the ‘kissing disease’, and the debilitating disease Multiple Sclerosis (MS).

24 Mar 2015

Harmful effects of smoking may be reflected in the facial movements of unborn babies

The harmful effects of smoking during pregnancy may be reflected in the facial movements of mothers' unborn babies, new research has suggested.

24 Mar 2015

Deuterium-containing sigma-1 agonist demonstrates anti-seizure, anti-inflammatory effects in TBI model

Research results published in the Journal of Neurotrauma and conducted by the Walter Reed Army Institute of Research (WRAIR) as part of a collaboration with Concert Pharmaceuticals, Inc. showed that a novel deuterium-containing sigma-1 agonist invented at Concert, called C-10068, demonstrated anti-seizure and anti-inflammatory effects in a preclinical model of traumatic brain injury (TBI).

24 Mar 2015

Funding helps researchers to kiss Multiple Sclerosis (MS) goodbye

24 Mar 2015

Keystone meeting focuses on neuroinflammation, Alzheimer's and other neurodegenerative diseases

As Alzheimer's disease sweeps through the brain, do the brain's immune cells sit idly by and let it happen? Or could they overreact and make the disease worse?

23 Mar 2015

Hydrazine not prevalent in smokeless tobacco products

After many years of speculation, it has finally been established that hydrazine is not a prevalent contaminant in contemporary smokeless tobacco products (STPs).

18 Mar 2015

New drug-like molecule shows promise in preventing MS progression

Walter and Eliza Hall Institute scientists have developed a new drug-like molecule that can halt inflammation and has shown promise in preventing the progression of multiple sclerosis (MS).

17 Mar 2015

Study shows fatigue pathways are more sensitive in patients with chronic fatigue syndrome

The mechanism that causes high-performance athletes to "feel the burn" turns out to be the culprit in what makes people with chronic fatigue syndrome feel exhausted by the most common daily activities, new University of Florida Health research shows.

13 Mar 2015

Cancer drug promotes neuronal regeneration after spinal cord injury

Damage to the spinal cord rarely heals because the injured nerve cells fail to regenerate. The regrowth of their long nerve fibers is hindered by scar tissue and molecular processes inside the nerves.

13 Mar 2015

Glucocorticoid therapies promote functional recovery of blood-brain barrier after blast injury

Barclay Morrison III, associate professor of biomedical engineering at Columbia Engineering, has led the first study to determine underlying biological mechanisms that promote functional recovery of the blood-brain barrier (BBB) after blast injury. The research demonstrates that treatment with the glucocorticoid, dexamethasone, after primary blast injury promotes rapid recovery of an in vitro model of the BBB, a highly restrictive semi-permeable barrier whose primary function is to maintain the brain's microenvironment and protect it from potentially toxic substances.

12 Mar 2015

New stem cell treatment reverses disability in certain MS patients

A PIONEERING new stem cell treatment ‘rebooting’ the immune system in some multiple sclerosis sufferers is being hailed as an encouraging step forward in the treatment of the disease in sufferers who fail to respond to standard therapies.

11 Mar 2015

UIC researchers identify genetic variation that increases MS risk in women

Researchers at the University of Illinois at Chicago have identified a genetic variation that in women significantly increases their risk of developing multiple sclerosis.

5 Mar 2015

Enrollment completed in Pharma Two B's P2B001 Phase IIb study for Parkinson's disease treatment

Pharma Two B announced today that enrollment has been completed in the company's Phase IIb study of P2B001 for the treatment of early stage Parkinson's disease. One hundred and forty-nine patients enrolled in the study conducted at 29 clinical sites throughout the US and Israel.

4 Mar 2015

Grifols, Alkahest sign definitive agreements

Grifols, a global healthcare company and leading producer of plasma therapies, and Alkahest, a Redwood City, California based, privately held biopharmaceutical company founded upon the pioneering work of Dr. Tony Wyss-Coray and other leading scientists at Stanford University, today announced that they have signed definitive agreements whereby Grifols will make a major equity investment in Alkahest, and the companies will work together to develop novel plasma-based products for the treatment of cognitive decline in aging and disorders of the central nervous system (CNS), including Alzheimer's.

4 Mar 2015

Existing drug could help treat MS, other neurological diseases

Damage to myelin, the fatty insulator that enables communication between nerve cells, characterizes multiple sclerosis (MS) and other devastating neurological diseases.

3 Mar 2015

TREM2 protein may help slow progression of multiple sclerosis, Alzheimer's disease

Highlighting a potential target in the treatment of multiple sclerosis (MS) and Alzheimer's disease, new research suggests that triggering a protein found on the surface of brain cells may help slow the progression of these and other neurological diseases.

3 Mar 2015

Study shows importance of disclosing physician conflicts of interest in MS ISCTs to potential participants

If you're one of the nearly half a million Americans living with multiple sclerosis (MS) - a slowly disabling disease of the central nervous system - you are likely dependent on disease-modifying drugs to prevent symptoms such as vision problems, balance issues and weakness. Often, these treatments have been developed through pharmaceutical industry-sponsored clinical trials (ISCT) in collaboration with academic or private practice physicians who care for MS patients.

2 Mar 2015

Central Nervous System News and Research

CNIO researchers describe presence of MDH2 gene mutations in hereditary neuroendocrine tumors

Researchers present new studies on cognition and reasoning at CNS conference in San Francisco

Experimental drug that attacks brain tumor cells passes early tests

Funding helps researchers to kiss MS goodbye

Harmful effects of smoking may be reflected in the facial movements of unborn babies

Deuterium-containing sigma-1 agonist demonstrates anti-seizure, anti-inflammatory effects in TBI model

Funding helps researchers to kiss Multiple Sclerosis (MS) goodbye

Keystone meeting focuses on neuroinflammation, Alzheimer's and other neurodegenerative diseases

Hydrazine not prevalent in smokeless tobacco products

New drug-like molecule shows promise in preventing MS progression

Study shows fatigue pathways are more sensitive in patients with chronic fatigue syndrome

Cancer drug promotes neuronal regeneration after spinal cord injury

Glucocorticoid therapies promote functional recovery of blood-brain barrier after blast injury

New stem cell treatment reverses disability in certain MS patients

UIC researchers identify genetic variation that increases MS risk in women

Enrollment completed in Pharma Two B's P2B001 Phase IIb study for Parkinson's disease treatment

Grifols, Alkahest sign definitive agreements

Existing drug could help treat MS, other neurological diseases

TREM2 protein may help slow progression of multiple sclerosis, Alzheimer's disease

Study shows importance of disclosing physician conflicts of interest in MS ISCTs to potential participants

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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