Bile News and Research

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Study represents a major step in seeking alternative cancer treatments for non-responders

Research led by VHIO's Alena Gros signposts a new, less invasive approach to identify killer T lymphocytes in patients with gastrointestinal tumors with low mutational burden who are refractory to approved immune-based treatments.

16 Oct 2019

Good news for IBS sufferers as researchers identify “gut itch”

Researchers have identified receptors that cause the pain experienced in cases of irritable bowel syndrome.

16 Oct 2019

SOX9 broadly modifies the severity of Alagille syndrome liver disease in mice

Alagille syndrome is a rare pediatric genetic disorder that can affect the liver, heart, kidneys, blood vessels, skeleton and other tissues.

11 Oct 2019

How do gallstones form?

The human body is known to produce stones in various locations, most commonly in the kidneys, the bladder, the gallbladder and the appendix. Many of these stones appear without any obvious reason. However, a new study published in the journal Immunity shows the whole storyline for the first time: how gallstones are formed.

9 Oct 2019

Functional three-organoid stem cell system could lead to unprecedented advances for precision medicine

Using iPS cells, a Japanese research group has successfully grown a connected set of organs at the same time, including a liver and a pancreas connected by a bile duct.

27 Sep 2019

New AGA guideline on evaluation of chronic diarrhea released

Diagnosing patients with chronic watery diarrhea can be difficult for health care providers, since several causes with specific therapies, such as inflammatory bowel disease (IBD), microscopic colitis and chronic infection, need to be ruled out.

23 Sep 2019

Diarrhea linked significantly to weight gain

A study has shown that obesity is linked to chronic diarrhea, independent of other lifestyle or eating habits.

19 Sep 2019

Multidrug-resistant bacteria may have been around longer than thought

Researchers from Osaka University have made the striking discovery that multidrug-resistant bacteria may have been around longer than we thought.

13 Sep 2019

Supercooling helps preserve human transplant organs longer

Now a new supercooling technique for human organs promises to extend the period from the moment of removal to 1.5 days rather than just a few hours. This provides a useful window of time within which transplant teams and patients can hope to get a viable organ.

10 Sep 2019

Gut microbiome and IBD – the connection maybe in diet says study

A new study has shown conclusive evidence that inflammatory bowel disease or IBD is intimately associated with the gut microbial environment which can be altered with prescription diet. The microbiome within the human gut is a collection of healthy and helpful bacteria that help in several functions of the body including development and maintenance of immunity.

10 Sep 2019

Microbiome loss from antibiotic use affects response to flu vaccine

Every living person has trillions of microbes living in their digestive tract, and more than 400 species of bacteria in the gut, more than the number of cells in the body. The normal gut flora is important to maintain eubiosis, the microbial balance in the body.

9 Sep 2019

Oral antibiotics that kill gut microorganisms can alter immune response to flu vaccines

The normal human gut microbiome is a flourishing community of microorganisms, some of which can affect the human immune system. In a new paper published this week in Cell, researchers found that oral antibiotics, which can kill gut microorganisms, can alter the human immune response to seasonal influenza vaccination.

8 Sep 2019

Younger people getting cancer due to obesity

Obesity rates around the globe are ballooning - literally! Approximately 1.9 billion adults who are 18 years and older were overweight in 2016, and of these, more than 650 million were obese. The number of obese people has nearly tripled since 1975.

4 Sep 2019

FDA recommends health care facilities to transition away from fixed endcap duodenoscope models

Today, the U.S. Food and Drug Administration is recommending that duodenoscope manufacturers and health care facilities transition to different types of duodenoscopes that may pose less risk to patient safety.

31 Aug 2019

Remodeling unhealthful gut microbiomes with the help of synthetic peptides

You are what you eat -; right down to the microbiome living in your gut. Diet can affect which microbes are in the intestinal tract, and research has shown that harmful gut microbiome changes can lead to illnesses such as heart disease, obesity and cancer.

27 Aug 2019

Researchers discover how fatty liver disease develops in lean people

Researchers from The Westmead Institute for Medical Research (WIMR) have discovered how fatty liver disease develops in lean people, aiding the development of potential treatments for these patients.

26 Aug 2019

Gallstone formation may be driven by neutrophils

Neutrophils generate sticky webs of DNA called neutrophil extracellular traps (NETs) that act as a “glue” during gallstone formation.

19 Aug 2019

Bile pigment may play an unexpected role in protecting the brain

In studies in mice, Johns Hopkins Medicine researchers report they have found that bilirubin, a bile pigment most commonly known for yellowing the skin of people with jaundice, may play an unexpected role in protecting brain cells from damage from oxidative stress.

From Johns Hopkins Medicine 13 Aug 2019

Discovery of unusual HBV in shrews offers new opportunity to better understand the disease

The discovery of an unusual hepatitis B virus from shrews offers new opportunities of better understanding the chronic progression of the disease. International research teams were able to demonstrate that an important protein which is essential for the development of a chronic course of infection is not present in this virus.

3 Aug 2019