Cell Membrane News and Research

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Human gingival epithelial cells become damaged by cannabis smoke condensate

In a new study, scientists evaluated the effect of cannabis smoke condensate (CSC) on the gingival epithelial cells.

5 Jul 2022

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

The viral replication cycle is crucial for a virus to spread inside the body and cause disease. Focusing on that cycle in the hepatitis A virus (HAV), UNC School of Medicine scientists discovered that replication requires specific interactions between the human protein ZCCHC14 and a group of enzymes called TENT4 poly(A) polymerases.

4 Jul 2022

Identification of potent SARS-CoV-2 macrodomain inhibitors

A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) inhibitor based on structure.

30 Jun 2022

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

Scientists create new fluorophores that could help fight cancer

Scientists from the Ural Federal University and the Ural Branch of the Russian Academy of Sciences have created new fluorescent chemical compounds (fluorophores) for photodynamic therapy of cancerous tumors, the latest method of treating cancer.

27 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

Inhibiting pore formation in cells may facilitate prevention, treatment of NASH-associated liver cancer

Need another reason to think twice before ordering that extra helping of fries? It could lead to a higher risk of developing liver cancer.

24 Jun 2022

Researchers determine optimal conditions to perform impedance cytometry

Having a good eye for detail is an essential skill for many professions. In particular, biologists use special techniques and advanced technology to analyze individual cells with unprecedented precision.

24 Jun 2022

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag's N-terminal matrix domain.

21 Jun 2022

Study uncovers novel treatment for chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma (ChRCC) is a rare form of kidney cancer for which there are currently no proven treatments for metastatic or unresectable disease.

20 Jun 2022

GPR183 gene a novel drug target for severe COVID-19

In a recent study posted to the bioRxiv* pre-print server, researchers provide the first preclinical evidence of the usefulness of antagonists of G-protein coupled receptor 183 (GPR183), also known as Epstein-Barr virus-induced gene 2 (EBI2), in reducing coronavirus disease 2019 (COVID-19) severity.

17 Jun 2022

Effectiveness of a hybrid vaccine against COVID-19 and influenza

Researchers assessed the efficiency of a hybrid vaccine against influenza and COVID-19 viruses.

16 Jun 2022

New component of cell death process could play key role in infection-fighting strategy

Researchers have unmasked a component of the cell death process that could play a vital role in a better infection-fighting strategy.

16 Jun 2022

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

In a recent study posted to the bioRxiv* pre-print server, researchers illustrated the cryo-electron microscopic (cryo-EM) structure of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein in lipid nanodiscs to 3.5 angstroms (Å) resolution.

16 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

The severity of COVID-19 compared to seasonal influenza

In a recent study under review at the Archives of Virology journal and currently posted to the Research Square* preprint server, investigators in Israel assessed the disparities and similarities between seasonal influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Jun 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Study shines new light on the role of key Parkinson’s disease protein

One of the hallmarks of Parkinson's disease (PD) is the accumulation in the brain of a protein known as alpha-synuclein. For more than two decades, alpha-synuclein has been a focal point of attention for researchers, clinicians and drug makers interested in PD.

9 Jun 2022

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

Several years ago, a promising therapeutic using stem cell factor (SCF) emerged that could potentially treat a variety of ailments, such as ischemia, heart attack, stroke and radiation exposure.

8 Jun 2022

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

Researchers at UT Southwestern have developed a first-of-its-kind ultrasound-guided cancer immunotherapy platform that delivers immune-stimulating agents to cells for the development of systemic anti-tumor immunity.

7 Jun 2022

Cell Membrane News and Research

Human gingival epithelial cells become damaged by cannabis smoke condensate

Scientists discover how a protein and enzymes interact to allow hepatitis A virus replication

Identification of potent SARS-CoV-2 macrodomain inhibitors

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

Scientists create new fluorophores that could help fight cancer

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Inhibiting pore formation in cells may facilitate prevention, treatment of NASH-associated liver cancer

Researchers determine optimal conditions to perform impedance cytometry

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Study uncovers novel treatment for chromophobe renal cell carcinoma

GPR183 gene a novel drug target for severe COVID-19

Effectiveness of a hybrid vaccine against COVID-19 and influenza

New component of cell death process could play key role in infection-fighting strategy

Cryo-electron microscopy structure of SARS-CoV-2 membrane protein

The potential mechanisms of SARS-CoV-2 to induce DNA damage

The severity of COVID-19 compared to seasonal influenza

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Study shines new light on the role of key Parkinson’s disease protein

New therapeutic avoids major allergic reactions while maintaining therapeutic activity

New microbubble-assisted ultrasound-guided immunotherapy helps improve anti-tumor immunity

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