DNA Damage News and Research

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Breakthrough research reveals how to target malignant DNA in aggressive cancers

Scientists have discovered a way to target elusive circular fragments of DNA that drive the survival of some of the most aggressive cancers, paving the way for future treatments.

9 Nov 2024

How bacteria trigger colon cancer

Investigation shows how bacterial adhesins contribute to colon cancer mutations, suggesting new avenues for therapeutic intervention in colorectal cancer.

7 Nov 2024

Epigenetic silencing of BEND4 unveils new path for PDAC treatment

A novel discovery in the field of pancreatic cancer treatment has been unveiled, revealing the epigenetic silencing of BEND4 as a potential synthetic lethal marker for enhancing the efficacy of ATM inhibitors in pancreatic cancer treatment.

7 Nov 2024

Study uncovers how certain E. coli bacteria in the gut promote colon cancer

Scientists have uncovered how certain E. coli bacteria in the gut promote colon cancer by binding to intestinal cells and releasing a DNA-damaging toxin.

6 Nov 2024

A novel synthetic lethal target for ATM inhibitors in pancreatic cancer

5 Nov 2024

Radioprotective effects of Licochalcone B against radiation-induced cell damage

Radiation injury poses a serious threat to human health, causing complex and multifaceted damage to cells and tissues. Such injury can be caused by various factors, including nuclear accidents, medical radiation therapy, and space travel.

29 Oct 2024

Unraveling the mystery of cancer resistance

Every multicellular creature - whether soaring through the skies, swimming in the ocean's depths or roaming the earth's surface - shares a common vulnerability: the uncontrolled growth of cells known as cancer.

29 Oct 2024

Persistent activation of DNA damage response in the liver after MASLD reversal

Metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced form, metabolic dysfunction-associated steatohepatitis, have emerged as the most prevalent liver diseases worldwide.

25 Oct 2024

Key mutations discovered in cancer cells linked to WRN inhibitor resistance

Researchers have discovered key mutations in certain cancer cells that make them resistant to WRN inhibitors, a new class of anti-cancer drugs.

24 Oct 2024

Study reveals complex role of polyploidy in cancer and treatment resistance

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies.

21 Oct 2024

Polyploidy can be a double-edged sword in cancer

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies.

21 Oct 2024

Breakthrough in understanding microtubule formation in cells

Inside every cell, a network of tiny filaments, called the microtubule cytoskeleton, helps maintain the cell's shape, allows it to divide, and transports vital materials from one part of the cell to another.

15 Oct 2024

Discovery of USP50 protein sheds light on DNA replication processes

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified in a new study.

14 Oct 2024

Understanding the impact of sperm DNA damage on IVF pregnancy risks

For the first time, researchers have linked specific frequent defects in sperm to risk of pregnancy complications and negative impacts on the health of the baby.

12 Oct 2024

Researchers identify cause and potential therapeutic approach for diabetic kidney disease

Diabetic kidney disease – a complication of diabetes – is considered the leading cause of chronic kidney disease and kidney failure worldwide.

10 Oct 2024

New research offers hope for treating metabolic dysfunction-associated liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) — previously known as "non-alcoholic fatty liver disease" — affects about 25% of the global population.

9 Oct 2024

Mosaic Therapeutics appoints Dr Barry Davies as CSO

Dr. Barry Davies joins Mosaic Therapeutics as CSO, bringing 25 years of drug discovery expertise to advance targeted oncology therapies and precision medicine.

8 Oct 2024

Common breast cancer therapies may speed up aging, study shows

A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center has revealed that common breast cancer treatments, including chemotherapy, radiation, and surgery, may accelerate the biological aging process in breast cancer survivors.

8 Oct 2024

When CDK12/13 stalls, healthy prostate cells take a malignant turn

CDK12 is established as a tumor suppressor in prostate cancer, with its loss driving aggressive disease and creating vulnerabilities for targeted therapies.

7 Oct 2024

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment.

4 Oct 2024