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Analyzing cancer-specific alterations found in tumor's RNA

Researchers at EMBL-EBI were among the leaders of a large international consortium that carried out a joint analysis of data from over 1000 donors of more than 25 cancer types, studying data on their whole genomes along with tumor transcriptome data, which indicates the genes that are active within a tumor.

6 Feb 2020

Successful gene therapy trial in patients with X-linked Chronic Septic Granulomatosis

American and British teams led by Drs Kohn (University of California, Los Angeles), Malech (NIH), Williams (Boston Children's) and Trasher (Great Ormond Street Institute of Child Health) published yesterday in Nature Medicine the conclusive results of a gene therapy trial conducted in the United States and Great Britain in 9 patients with X-linked Chronic Septic Granulomatosis (X-CGD), a rare and severe immune dysfunction. Six of them are free of treatment for complications generated by the disease.

28 Jan 2020

Scientists discover new drug target for prostate cancer in the non-coding genome

Scientists at Princess Margaret Cancer Centre have identified the drivers of a crucial gene involved in prostate cancer, revealing new targets for drug design.

23 Jan 2020

'Methylation clock' gene found to have functional role in aging of the eye

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age.

16 Jan 2020

New method uses MRI, machine learning to forecast genetic mutations in glioma tumors

Researchers at Osaka University have developed a computer method that uses magnetic resonance imaging (MRI) and machine learning to rapidly forecast genetic mutations in glioma tumors, which occur in the brain or spine. The work may help glioma patients to receive more suitable treatment faster, giving better outcomes.

9 Jan 2020

New research could lead to an improved vaccine to protect against meningococcal infections

New research from experts at the University of Nottingham could lead to an improved vaccine to protect against the bacterium, Neisseria meningitides that causes sepsis and meningitis.

22 Dec 2019

Data results of NCI-MATCH trial in tumors with DNA mismatch repair deficiencies

Final results are published from an evaluation of 42 patients treated with the immune checkpoint inhibitor nivolumab in the large multi-arm precision medicine trial, NCI-Molecular Analysis for Therapy Choice (NCI-MATCH or EAY131).

20 Dec 2019

Using math equations to detect and forecast liver cancer risk

The use of mathematical modeling in the study of biological systems has become a challenging and rewarding field of research as it yields many unknown pieces of information. A new study published online on December 16, 2019, in the journal Proceedings of the National Academy of Science (PNAS).

17 Dec 2019

Researchers discover regulatory map of the human EphB4 gene

Pierluigi Scalia and coworkers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia, and the affiliated Italian research organization ISOPROG, have announced the regulatory map of the human EphB4 gene.

3 Dec 2019

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

25 Nov 2019

Cell factors decide if a cancer grows or dies, says new study

A new study published today in the journal Cell Reports by scientists at the German Cancer Research Center (DKFZ) shows that the direction taken by a cancer cell depends on the configuration of the cell itself as well as the activation of a universal cancer cell receptor called CD95.

19 Nov 2019

Altering malarial parasite genes to prevent malaria

Malaria is a mosquito-borne disease caused by the parasitic organism called Plasmodium, of which there are several types that cause the different kinds of malarial fever. This age-old infection still kills over 400,000 people every year, all over the world. A new study published in the journal Cell on November 14, 2019, shows how a simple tweaking of the genes of this organism could quite conceivably lead to the elimination of this disease altogether.

14 Nov 2019

Clinical analysis reveals high expression of apoptosis protein in chemoresistant TNBC

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

13 Nov 2019

Juvenile immune arthritis – new treatments wanted

Juvenile immune arthritis (JIA) is a severely undertreated condition, and new medications are badly needed to relieve the signs and symptoms of the illness, according to a new study presented at the 2019 ACR/ARP Annual Meeting.

11 Nov 2019

Scientists discover role for vitamin D in melanoma

A new study published in Cancer Research suggests that high levels of vitamin D may reduce the aggressive nature of melanoma cells and improve survival rates.

8 Nov 2019

How the SETD1A gene produces schizophrenia in mice

A new study published in the journal Neuron on October 9, 2019 reports that scientists have unlocked part of the secrets of the SETD1A gene – how mutations in the gene put the individual at risk for the condition.

26 Oct 2019

HIV-1 Tat expression leads to perturbations in cellular protein expression, research suggests

The cover for issue 54 of Oncotarget features Figure 2, "Comparative proteomic profiling of the peptides/proteins identified from 293T, IL16lamp2b and mExo-Tat samples," by Lu, et al.

4 Oct 2019

Researchers elucidate enzymes that control long-term memory, learning process in the brain

When we first purchase a smart phone, all of our settings and applications are the same. But as time passes, everyone's phones will change drastically as we adapt them to our own individual needs and preferences. In the same way, our memories and life experiences are loaded into our brains, making one person unique from another.

2 Oct 2019

Scientists use ultrasound to detect active genes in live cells

A startling new study shows that ultrasound can help scientists to understand whether specific genes are in the active or inactive state in live cells.

27 Sep 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019