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Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

A Phase 2 trial led by City of Hope, a world-renowned research and treatment center for cancer and diabetes, suggests that adding the novel ataxia telangiectasia and Rad3-related (ATR) inhibitor drug berzosertib to standard-of-care chemotherapy for patients with metastatic urothelial cancer does not extend progression-free survival.

27 Aug 2021

Researchers assess the significance of rehabilitation exercises for osteoarthritis patients

Osteoarthritis is a disease of the whole joint, typified by structural alterations in bone, ligaments, and joints, that render them weak. In its severe form, it is extremely debilitating for patients, resulting in hindered mobility and the incidence of severe pain.

27 Aug 2021

Researchers identify mechanism for formation of rare colorectal cancer subtype

Researchers from Rutgers Cancer Institute of New Jersey, the state's only National Cancer Institute-designated Comprehensive Cancer Center, recently discovered a mechanism to explain what drives the formation of mucinous colorectal adenocarcinoma (MAC), a rare subtype of colorectal cancer (CRC), and has also identified the genes responsible for the regulation of this mechanism.

25 Aug 2021

NIH grant renewed to continue work at the Penn Center for Musculoskeletal Disorders

Long-time funding for work at the Penn Center for Musculoskeletal Disorders has been renewed for another five years by the National Institute of Arthritis, Musculoskeletal, and Skin Diseases of the National Institutes of Health.

25 Aug 2021

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

New information from a study reported on in STEM CELLS might result in more effective treatments for osteoarthritis and other cartilage diseases, as well as hereditary disorders affecting cartilage development.

25 Aug 2021

Population peak could contribute to less meaningful social interactions and reproduction suppression

A predicted population drop at the end of the century could be explained by stress from meaningless social interactions, according to a review article published in the Endocrine Society's journal, Endocrinology.

24 Aug 2021

Waterloo experts are developing new cancer treatments with high-intensity focused ultrasound

Researchers are bringing the use of acoustic waves to target and destroy cancerous tumors closer to reality.

24 Aug 2021

Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

A team of scientists from Australia has recently identified a frameshift deletion mutation in ORF7a of the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The mutation results in the production of a truncated peptide with altered functionality. The study is currently available on the medRxiv* preprint server while awaiting peer review.

24 Aug 2021

Analysis of seadragon genome offers new insights into its phenotype and sex-determination locus

A study by Prof. LIN Qiang from the South China Sea Institute of Oceanology (SCSIO) of the Chinese Academy of Sciences and his collaborators from Singapore and Germany lifts the veil on seadragons' mysterious looks, and sheds light on a sex-determination locus shared by seadragons and alligator pipefish, both members of the Syngnathidae family.

22 Aug 2021

Study illuminates genetic understanding of aggressive childhood leukemias

New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination.

20 Aug 2021

First-ever endoscopic "triple valve" surgery in the U.S. performed at UC Medical Center

UC Health cardiac surgeons have successfully performed the United States' first-ever endoscopic "triple valve" surgery at UC Medical Center.

19 Aug 2021

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

A scientific achievement for researchers at Tel Aviv University: printing an entire active and viable glioblastoma tumor using a 3D printer.

18 Aug 2021

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

A new phase I clinical study shows, for the first time, how treatment with a type of stem cell called mesenchymal stromal cells is able to regulate important factors driving inflammation in patients with chronic obstructive pulmonary disease (COPD) for a period for time.

18 Aug 2021

Treatment with stem cell grafts promotes tendon healing in sheep

Tendon injuries in sheep that were treated with stem cell grafts achieved, in just two months, a diameter and hardness similar to the original healthy tendon, according to the results of a study released in STEM CELLS Translational Medicine.

16 Aug 2021

Bioengineers develop implantable piezoelectric therapeutic devices

Bioengineers have developed biocompatible generators that create electrical pulses when compressed by body motions.

16 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

Bone News and Research

Adding berzosertib to standard treatment for metastatic urothelial cancer does not extend patient survival

Researchers assess the significance of rehabilitation exercises for osteoarthritis patients

Researchers identify mechanism for formation of rare colorectal cancer subtype

NIH grant renewed to continue work at the Penn Center for Musculoskeletal Disorders

New discovery may lead to more effective treatments for osteoarthritis, other cartilage diseases

Population peak could contribute to less meaningful social interactions and reproduction suppression

Waterloo experts are developing new cancer treatments with high-intensity focused ultrasound

Frameshift deletion mutation in ORF7a may provide fitness advantage to Australia's SARS-CoV-2 delta variants

Analysis of seadragon genome offers new insights into its phenotype and sex-determination locus

Study illuminates genetic understanding of aggressive childhood leukemias

First-ever endoscopic "triple valve" surgery in the U.S. performed at UC Medical Center

Researchers create the first 3D-bioprinted model of active glioblastoma tumor

Study shows how mesenchymal stromal cells regulate factors driving inflammation in COPD patients

Treatment with stem cell grafts promotes tendon healing in sheep

Bioengineers develop implantable piezoelectric therapeutic devices

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

UC San Diego scientists develop new method to keep cultured cells healthy

Natural vs. vaccine-induced COVID-19 immunity

Acclaimed Pacific Shores Medical Group joins City of Hope

Excess screen time detrimental to adolescents’ mental health

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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