Cell Death News and Research

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Targeting RNA repeats

RNA repeats are stretches of code in the body that incrementally repeat. For example, in the most common cause of adult-on-set muscular dystrophy a RNA has a repeat of r(CUG) and this three letter code can repeat thousands of times.

20 Feb 2017

MRC researchers discover genetic 'switch' that plays key role in Parkinson's disease

A genetic 'switch' has been discovered by MRC researchers at the University of Leicester which could help to prevent or delay the symptoms of Parkinson's disease.

17 Feb 2017

HCI researchers uncover how epithelial cells naturally turn over to maintain constant numbers

Research published today in Nature from scientists at Huntsman Cancer Institute (HCI) at the University of Utah shows how epithelial cells naturally turn over, maintaining constant numbers between cell division and cell death.

15 Feb 2017

Two-drug combination shows promise against diabetic retinopathy in animal models

A two-drug cocktail provided better protection against diabetes-related vision loss than a single drug during testing in rat models, a team of University of Florida Health and Dutch researchers has found.

15 Feb 2017

Analyzing copies of genes may offer new therapeutic approaches for ovarian cancer

A team of 18 University of California San Diego School of Medicine and Moores Cancer Center researchers has developed a new tool to analyze an often overlooked aspect of cancer genetics -- an alteration that results in the loss or gain in a copy of a gene.

15 Feb 2017

Scientists identify how imbalance of calcium in mitochondria may contribute to Alzheimer's disease

Calcium in the mitochondria -- the energy factory of cells -- may be one of the keys to understanding and treating Alzheimer's disease and dementia.

14 Feb 2017

Researchers unlock specific mechanisms behind Aβ-induced cytoxicity in Alzheimer's disease

Alzheimer's disease is a progressive neurodegenerative disorder that leads to dementia via advanced neuronal dysfunction and death. A person with Alzheimer's disease suffers loss of control over thought, memory and language abilities.

14 Feb 2017

LMU study shows crucial role of microRNAs in protecting precursors of neurons

Programmed cell death is an integral part of embryonic development. Exploring the regulation of the process, Ludwig-Maximilians-Universitaet in Munich researchers have shown that so-called microRNAs protect the precursors of neurons from 'precocious' elimination.

13 Feb 2017

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

Researchers have identified a gatekeeper protein that prevents pancreatic cancer cells from transitioning into a particularly aggressive cell type and also found therapies capable of thwarting those cells when the gatekeeper is depleted.

9 Feb 2017

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

A new therapeutic agent tested in a mouse model of multiple sclerosis (MS) produced anti-inflammatory activity and prevented loss of cells in the optic nerve, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania, with Pittsburgh-based Noveome Biotherapeutics.

9 Feb 2017

Loss of Golgi function may contribute to pathology of neurodegenerative diseases

Disabling a part of brain cells that acts as a tap to regulate the flow of proteins has been shown to cause neurodegeneration, a new study from The University of Manchester has found.

From The University of Manchester 9 Feb 2017

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Mycobacterium tuberculosis has been called "the perfect pathogen." These bacteria hijack human macrophages, persist inside the cells to evade immune destruction, and then prevent the macrophage from undergoing programmed cell death.

8 Feb 2017

Adjusting KYNA levels can have significant effects on schizophrenia-like behavior, mice study finds

A new study by University of Maryland School of Medicine researchers has found that in mice, adjusting levels of a compound called kynurenic acid can have significant effects on schizophrenia-like behavior. The study appeared in the latest issue of the journal Biological Psychiatry.

7 Feb 2017

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

Bladder dysfunction is a reality for about half of patients with diabetes and now scientists have evidence that an immune system receptor that's more typically activated by bacteria is a major contributor.

7 Feb 2017

New research shows that nuts can inhibit growth of cancer cells

Roasted and salted, ground as a baking ingredient or fresh from the shell - for all those who enjoy eating nuts, there is good news from nutritionists at Friedrich Schiller University Jena.

6 Feb 2017

Spatial structure of amyloid fibrils linked to Parkinson's disease highly dependent on salt concentration

By combining two-dimensional infrared spectroscopy and atomic force microscopy, Amsterdam researchers have established that the spatial structure of amyloid fibrils related to Parkinson's disease is highly dependent on salt concentration during protein aggregation.

6 Feb 2017

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital and King's College London have discovered a treatment that improves the neurological symptoms in a mouse model of juvenile Batten disease.

6 Feb 2017

Cell Death News and Research

Targeting RNA repeats

MRC researchers discover genetic 'switch' that plays key role in Parkinson's disease

HCI researchers uncover how epithelial cells naturally turn over to maintain constant numbers

Two-drug combination shows promise against diabetic retinopathy in animal models

Analyzing copies of genes may offer new therapeutic approaches for ovarian cancer

Scientists identify how imbalance of calcium in mitochondria may contribute to Alzheimer's disease

Researchers unlock specific mechanisms behind Aβ-induced cytoxicity in Alzheimer's disease

LMU study shows crucial role of microRNAs in protecting precursors of neurons

Scientists identify vulnerabilities of highly aggressive pancreatic cancer cells

New therapeutic agent shows potential for treating optic neuritis linked to multiple sclerosis

Loss of Golgi function may contribute to pathology of neurodegenerative diseases

New ‘release and kill’ strategy may shorten treatment periods for patients with tuberculosis

Adjusting KYNA levels can have significant effects on schizophrenia-like behavior, mice study finds

Scientists show how immune receptor activated by bacteria contributes to diabetic bladder dysfunction

New research shows that nuts can inhibit growth of cancer cells

Spatial structure of amyloid fibrils linked to Parkinson's disease highly dependent on salt concentration

Scientists discover treatment that improves symptoms in mouse model of juvenile Batten disease

Study provides insights into functions of astrocytes following brain injury or disease

Yale researchers identify new genetic defect in brain tumor cells that prevents DNA repair

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Event Guide: 3rd Annual TRP Supply Chain & Manufacturing Summit eBook

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Advancing degrader and proximity-based drug development

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Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics