Precision Medicine News and Research

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Novel polygenic hazard score captures age variations of aggressive prostate cancer

An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually.

12 Jan 2018

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

Mount Sinai Researchers have just discovered that patients in the Ashkenazi Jewish population with Crohn's disease (a chronic inflammatory of the digestive system) are more likely to carry the LRRK2 gene mutation.

11 Jan 2018

Study finds genetic variations linked to BMI and obesity risk

It's not just diet and physical activity; your genes also determine how easily you lose or gain weight. In a study published in the January issue of Nature Genetics, researchers at the Icahn School of Medicine at Mount Sinai and other institutions of the Genetic Investigation of Anthropometric Traits consortium found 13 genes that carry variations associated with body mass index.

10 Jan 2018

CHOP researchers explore effective nutritional therapies for mitochondrial disease

Defects in mitochondria, the tiny structures that power our cells by functioning as biological batteries, cause an array of complex, often life-threatening disorders that can affect any and all organs and systems.

10 Jan 2018

New discovery could help treat breast cancer through precision medicine

University of Alberta researchers have discovered a mechanism that may make cancer cells more susceptible to treatment. The research team found that the protein RYBP prevents DNA repair in cancer cells, including breast cancer.

9 Jan 2018

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

By the end of 2019, Regeneron plans to sequence the exomes of all 500,000 people within the UK Biobank resource, all with associated health records, creating an unprecedented resource linking human genetic variations to human biology and disease.

9 Jan 2018

Leukemia patients currently ineligible for targeted therapy may benefit from new drugs

Patients with an aggressive form of leukemia, currently ineligible for any type of targeted therapy, may in fact benefit from some of these new drugs, according to new research by Queen Mary University of London.

9 Jan 2018

New PET tracer can identify, track bacterial lung infection better than current imaging methods

Researchers at the University of Louisville, Kentucky, have demonstrated that a new radiotracer, 2-18F-fluorodeoxysorbitol (18F-FDS), can identify and track bacterial infection in lungs better than current imaging methods and is able to differentiate bacterial infection from inflammation.

8 Jan 2018

Newly identified biomarkers predict cancer patient’s response to immunotherapy

Researchers at the University of Zurich have identified biomarkers in the blood that make it possible to predict whether cancer patients will respond positively to immunotherapy.

8 Jan 2018

Polygenic risk score predicts early-onset heart disease risk

A risk score based on multiple genetic differences, or polygenic risk score, predicted significantly more cases of early-onset heart disease than standard tests for single genetic defects, according to new research in the American Heart Association's journal Circulation: Genomic and Precision Medicine.

8 Jan 2018

Genetic differences can influence efficiency of medicines

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency.

5 Jan 2018

UC Davis expert expresses caution on genetically engineered HSCs

In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death during transplantation.

4 Jan 2018

New yardstick offers practical recommendations for treatment of atopic dermatitis

Patients with atopic dermatitis (AD) - also known as eczema - often face a tough, uphill battle for treatment. Symptoms include severe itching, scaly rashes, extreme dry skin and inflammation.

4 Jan 2018

New total-body PET scanner could revolutionize patient diagnosis and care

The new total-body PET/CT scanner could revolutionize our understanding and treatment of disease through analysis of better imaging data from the whole body.

3 Jan 2018

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Research led by Ludwine Messiaen, Ph.D., professor of genetics at the University of Alabama at Birmingham, shows that missense mutations in a cluster of just five codons in the NF1 gene are an important risk factor for severe symptoms of the genetic disease neurofibromatosis type 1.

28 Dec 2017

Scientists discover five new regions of the genome that increase asthma risk

An international study led by scientists from Inserm and Paris Diderot Universit, the University of Chicago, the National Heart and Lung Institute and the University of Colorado Anschutz Medical Campus together with researchers of the Trans-National Asthma Genetics Consortium has discovered five new regions of the genome that increase the risk of asthma.

22 Dec 2017

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

The "mutational burden," or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

21 Dec 2017

Scientists identify new genes that influence how the body regulates blood pressure

Researchers at the University of Georgia have identified several new genes that influence how the body regulates blood pressure. This may help scientists develop novel blood pressure treatments or even allow them to tailor prevention strategies for individuals based on their genes.

19 Dec 2017

Researchers examine human mutations' impact on therapeutic effect of medicine

Every person has a unique DNA sequence in their genome. Now researchers from the University of Copenhagen and the MRC Laboratory of Molecular Biology in Cambridge have tried to quantify what these differences in the genome mean in the context of the genes targeted by drugs.

15 Dec 2017

Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies

Porvair Sciences are teaming up with Suzhou Tianlong Bio Technology Co Ltd (China), together with Swansea University and Xi'an Jiaotong University in a collaborative project entitled, "Automating & Stratification of Epigenetics in Healthcare" that is part of the Innovate UK / Jiangsu Industrial Challenge Programme.

From Chromatrap® - Porvair Sciences Ltd 15 Dec 2017

Precision Medicine News and Research

Novel polygenic hazard score captures age variations of aggressive prostate cancer

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

Study finds genetic variations linked to BMI and obesity risk

CHOP researchers explore effective nutritional therapies for mitochondrial disease

New discovery could help treat breast cancer through precision medicine

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

Leukemia patients currently ineligible for targeted therapy may benefit from new drugs

New PET tracer can identify, track bacterial lung infection better than current imaging methods

Newly identified biomarkers predict cancer patient’s response to immunotherapy

Polygenic risk score predicts early-onset heart disease risk

Genetic differences can influence efficiency of medicines

UC Davis expert expresses caution on genetically engineered HSCs

New yardstick offers practical recommendations for treatment of atopic dermatitis

New total-body PET scanner could revolutionize patient diagnosis and care

UAB study shows missense mutations as key risk factor for severe symptoms of neurofibromatosis type 1

Scientists discover five new regions of the genome that increase asthma risk

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

Scientists identify new genes that influence how the body regulates blood pressure

Researchers examine human mutations' impact on therapeutic effect of medicine

Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies

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