Genetic News and Research

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Study could lead towards a personalised medicine for chemoresistant lymphomata

To date, tests have only been carried out on cells, but a piece of research conducted by the Department of Genetics at the UPV/EHU's Faculty of Medicine in collaboration with MD Anderson and the CNIO is opening up the door for the treatment of lymphoma types that have a lower survival rate. The study of the molecular characteristics of the tumours would enable molecules that are altered in a specific way to be identified and turned into new therapeutic targets that would improve the prognosis of patients with chemoresistant lymphomata.

16 Dec 2013

New approach for combating seasonal flu

Reducing glucose metabolism dials down influenza viral infection in laboratory cell cultures, providing an entirely new approach for combating seasonal flu, according to research that will be presented on Sunday, Dec. 15, at the American Society for Cell Biology annual meeting in New Orleans.

15 Dec 2013

Daily exercise lessens harmful physiological effects of short-term overeating, inactivity, says study

Daily exercise lessens many of the harmful physiological effects of short-term overeating and inactivity, shows a new study [published 15 December] in The Journal of Physiology, which is well timed with the Christmas holiday approaching.

15 Dec 2013

Four U.S. researchers to receive grants to improve cognition in individuals living with Down syndrome

The Scientific Advisory Board of the Jerome Lejeune Foundation USA has recommended 4 U.S. researchers to receive grants from the Foundation for its second funding cycle of 2013.

15 Dec 2013

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

The Genetics Society of America (GSA) is pleased to announce the selection of eleven early career researchers - five graduate students and six postdoctoral researchers - as recipients of a spring 2014 DeLill Nasser Award for Professional Development in Genetics.

15 Dec 2013

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

A study in mice shows how a breakdown of the brain's blood vessels may amplify or cause problems associated with Alzheimer's disease. The results published in Nature Communications suggest that blood vessel cells called pericytes may provide novel targets for treatments and diagnoses.

14 Dec 2013

Deep genome sequencing used to predict clinical outcomes in patients with breast cancer tumors

New research from University Hospitals (UH) Case Medical Center Seidman Cancer Center and Case Comprehensive Cancer Center at Case Western Reserve University examined how changes in the genetic composition of breast cancer tumors after brief exposure to either biologic therapy or chemotherapy can predict future clinical outcomes in patients.

13 Dec 2013

New mutations in the estrogen receptor drive strong drug resistance exhibited by human breast tumors

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

13 Dec 2013

New test may help decrease risk of suicidality in patients treated with antidepressants

The new test, based on research carried out at the Max Planck Institute of Psychiatry, should help doctors to decrease the risk of suicidality in patients treated with antidepressants who show certain gene markers. Sundance is completing a new round of funding to extend the initial validation results reported by the Institute. The company plans to launch the test immediately as a laboratory developed test. In addition, clinical studies in support of a U.S. Food and Drug Administration submission for market clearance, CE marking and reimbursement will be initiated. Sundance expects to submit its application to the agencies within 18 months.

13 Dec 2013

Bioethics Commission releases ethical recommendations to manage incidental and secondary findings

Researchers conduct a memory study, scan a participant's brain, and find more than they bargain for: a tumor. What do the researchers owe the participant? What does the participant want to know?

13 Dec 2013

Transport of bacterial substrates through injectisome observed almost in real time

When attacking body cells, bacteria, such as salmonellae or Yersinia (plague pathogens), inject specific bacterial proteins through hollow, syringe-like structures - called injectisomes - into the host cells. These substances reprogram the cells and can thus overcome their defense. From then on, they can infiltrate the cells unhindered in large numbers, and trigger diseases such as typhus, plague, or cholera.

13 Dec 2013

Standardized research approaches needed for developing new treatments for neurofibromatosis

As potentially effective new treatments for neurofibromatosis (NF) are developed, standardized research approaches—including outcome measures specific to NF—are needed. The first report from the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration has been published as a supplement to Neurology, the Official Journal of the American Academy of Neurology (AAN).

13 Dec 2013

Researchers uncover second rare genetic mutation linked to higher risk of Alzheimer's disease

A research team from The University of Nottingham has helped uncover a second rare genetic mutation which strongly increases the risk of Alzheimer's disease in later life.

13 Dec 2013

State highlights: States scramble to change newborn screening programs; obesity rate flat; New York hospital charges vary considerably

States across the country are making significant changes to their newborn screening programs after a Milwaukee Journal Sentinel investigation found that thousands of hospitals were sending babies' blood samples late to state labs that test for rare yet deadly genetic disorders. From keeping labs open on weekends to identifying problem hospitals and providing them with regular performance reports, dozens of health officials are reviewing and retooling their state-run programs (Gabler, 12/11).

13 Dec 2013

Names of 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences unveiled

The names of the 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences were unveiled at an exclusive ceremony at the NASA Ames Research Center, Mountain View, CA. At a total awarded amount of $21 million, sponsored by Sergey Brin & Anne Wojcicki, Jack Ma & Cathy Zhang, Yuri & Julia Milner and Mark Zuckerberg & Priscilla Chan, the prizes aim to celebrate scientists and generate excitement about the pursuit of science as a career.

13 Dec 2013

Gene Expression Barcode 3.0 tool proves to be a vital resource for cancer research

A newly improved internet research tool is helping cancer researchers and physicians make sense out of a deluge of genetic data from nearly 100,000 patients and more than 50,000 mice.

13 Dec 2013

Researchers find way to stop first part of breast cancer metastasis in mice

Cell biologists at Johns Hopkins have identified a unique class of breast cancer cells that lead the process of invasion into surrounding tissues. Because invasion is the first step in the deadly process of cancer metastasis, the researchers say they may have found a weak link in cancer's armor and a possible new target for therapy.

13 Dec 2013

More outreach needed for family members who carry genetic risks of cancer

A study done by researchers at Fox Chase Cancer Center shows that many relatives of patients who undergo testing for a gene linked to breast and ovarian cancers misinterpret the results, and less than half of those who could benefit from genetic testing say they plan to get tested themselves-despite the fact that knowing your genetic status may help catch the disease in its earliest stages.

13 Dec 2013

University of Colorado medical school professor uncovers variant of NKH

People from around the country and the world turn to Johan Van Hove, MD, PhD, for advice on a rare metabolic disease known as NKH, which can disrupt the body in devastating and even deadly ways. Now, Van Hove, a University of Colorado medical school professor, has identified a new disease related to NKH, a finding that resolves previously baffling cases including the death of a Colorado girl.

13 Dec 2013

Boys who grow up in two-parent homes less likely to have high blood pressure as adults

In a study of African-American men, researchers from the National Institutes of Health found that boys who grew up in two-parent homes were less likely to have high blood pressure as adults compared to those raised by a single parent. Reported in the Dec. 12, 2013, issue of the journal Hypertension, this is the first study of an African-American population to document an association between childhood family living arrangements and blood pressure.

13 Dec 2013

Genetic News and Research

Study could lead towards a personalised medicine for chemoresistant lymphomata

New approach for combating seasonal flu

Daily exercise lessens harmful physiological effects of short-term overeating, inactivity, says study

Four U.S. researchers to receive grants to improve cognition in individuals living with Down syndrome

Eleven researchers receives 2014 DeLill Nasser Award for Professional Development in Genetics

Study: Brain blood vessel cells may be therapeutic targets for Alzheimer's disease

Deep genome sequencing used to predict clinical outcomes in patients with breast cancer tumors

New mutations in the estrogen receptor drive strong drug resistance exhibited by human breast tumors

New test may help decrease risk of suicidality in patients treated with antidepressants

Bioethics Commission releases ethical recommendations to manage incidental and secondary findings

Transport of bacterial substrates through injectisome observed almost in real time

Standardized research approaches needed for developing new treatments for neurofibromatosis

Researchers uncover second rare genetic mutation linked to higher risk of Alzheimer's disease

State highlights: States scramble to change newborn screening programs; obesity rate flat; New York hospital charges vary considerably

Names of 2014 Breakthrough Prize winners in Fundamental Physics and Life Sciences unveiled

Gene Expression Barcode 3.0 tool proves to be a vital resource for cancer research

Researchers find way to stop first part of breast cancer metastasis in mice

More outreach needed for family members who carry genetic risks of cancer

University of Colorado medical school professor uncovers variant of NKH

Boys who grow up in two-parent homes less likely to have high blood pressure as adults

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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