Clinical Trial News and Research

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Scientists develop safer CAR T-cell strategy for treating lymphomas

In the treatment of aggressive lymphomas and blood cancer (leukaemia), so-called chimeric antigen receptor T cells (CAR T cells) are increasingly being used.

9 Feb 2024

Selective androgen receptor modulator has anti-tumor effects in ER-positive breast cancer patients

A research paper published today (8 February 2024) in The Lancet Oncology demonstrates that the drug enobosarm, a selective androgen receptor modulator which stimulates the male sex hormone receptor has anti-tumour effects in estrogen receptor positive breast cancer patients.

8 Feb 2024

Stroke patients see lower death rates with AI-guided treatment

Ischemic stroke survivors who received care recommendations from an artificial intelligence (AI)-based system had fewer recurrent strokes, heart attacks or vascular death within three months, compared to people whose stroke treatment was not guided by AI tools, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2024.

8 Feb 2024

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

A new research perspective was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma."

8 Feb 2024

Flat positioning may give stroke patients an edge before surgery

Positioning patients with large vessel ischemic (clot-caused) stroke with their heads flat (0-degrees) before surgery to remove the blood clot resulted in significant improvements in neurological function, compared to patients whose heads were elevated (at a 30-degree angle), according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2024.

8 Feb 2024

NCCN publishes first-ever treatment recommendations pertaining to neuroblastoma

The National Comprehensive Cancer Network (NCCN) - an alliance of leading cancer centers - today published its first ever set of treatment recommendations pertaining to neuroblastoma.

8 Feb 2024

Study explores traditional Atlantic diets as a potential solution for diet-related diseases and environmental sustainability

Researchers from Spain investigated the effect of a traditional Atlantic diet on health and the environment.

8 Feb 2024

Combining clot busters and blood thinners shows no advantage for people with ischemic strokes

Giving blood thinners in addition to clot-busting medications to people with ischemic strokes (clot-caused strokes) did not improve their outcomes 90 days later, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2024.

7 Feb 2024

Reducing unnecessary testing or treatments in older patients

When a doctor ordered a routine prostate screening for an 80-year-old man - as doctors often do - a dramatic yellow alert popped up on the electronic health record with dire warnings.

7 Feb 2024

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

AMG 133, an engineered bispecific molecule, demonstrated significant weight loss with a favorable safety profile in a phase 1 clinical trial, offering a promising new treatment option for obesity.

7 Feb 2024

Snacking on pistachios may combat metabolic syndrome risk without weight gain

More than half of Americans do not currently meet the daily recommendation of 5–7 ounce equivalents of nuts and seeds per week.

7 Feb 2024

Experimental mRNA vaccine against CMV elicits promising immune responses

An experimental mRNA vaccine against human cytomegalovirus (CMV), a common virus that can infect babies during pregnancy, elicited some of the most promising immune responses to date of any CMV vaccine candidate, according to a study by Weill Cornell Medicine investigators.

7 Feb 2024

New link between stress, immune system, and depression discovered

Chronic stress affects the immune system and the brain. UZH researchers now show that a particular enzyme found in cells of the immune system enters the brain under stress.

7 Feb 2024

AI helps predict antidepressant response in a week

In patients with major depression disorder it is, thanks to use of artificial intelligence, now possible to predict within a week whether an antidepressant will work.

7 Feb 2024

Eleven stroke researchers to be recognized during the 2024 International Stroke Conference

Eleven scientists leading the way in stroke research will be recognized during the American Stroke Association's International Stroke Conference 2024 for their exceptional professional achievements.

6 Feb 2024

New cell therapy shows promise for critically ill COVID-19 patients with ARDS

Promising trial results indicate that a new type of cell therapy could improve the prognosis of those who are critically ill with acute respiratory distress syndrome (ARDS) resulting from severe Covid-19.

6 Feb 2024

Doppler ultrasound detects placental issues in small babies, study finds

A Doppler ultrasound that measures the blood flow of small unborn babies can reveal whether or not the placenta is working properly. In case of repeated deviations from these Doppler measurements, additional monitoring of the unborn baby is necessary.

5 Feb 2024

New weight loss drug may be an effective strategy for preventing or treating high blood pressure

The new weight loss medication tirzepatide significantly lowered the systolic blood pressure (the top number in a blood pressure reading) for nearly 500 adults with obesity who took the medication for about eight months, according to new research published today in Hypertension, an American Heart Association journal.

5 Feb 2024

First gene therapy trial aims to restore hearing in children

The aim of this clinical trial, which has just received approval in France, is to assess the safety and efficacy of a new gene therapy drug in children aged between 6 and 31 months with profound hearing loss.

5 Feb 2024

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer

A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research Institute (IGTP) have found a new therapeutic strategy for patients with a specific subtype of metastatic prostate cancer resistant to standard chemotherapy treatment with docetaxel.

5 Feb 2024

Clinical Trial News and Research

Scientists develop safer CAR T-cell strategy for treating lymphomas

Selective androgen receptor modulator has anti-tumor effects in ER-positive breast cancer patients

Stroke patients see lower death rates with AI-guided treatment

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

Flat positioning may give stroke patients an edge before surgery

NCCN publishes first-ever treatment recommendations pertaining to neuroblastoma

Study explores traditional Atlantic diets as a potential solution for diet-related diseases and environmental sustainability

Combining clot busters and blood thinners shows no advantage for people with ischemic strokes

Reducing unnecessary testing or treatments in older patients

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

Snacking on pistachios may combat metabolic syndrome risk without weight gain

Experimental mRNA vaccine against CMV elicits promising immune responses

New link between stress, immune system, and depression discovered

AI helps predict antidepressant response in a week

Eleven stroke researchers to be recognized during the 2024 International Stroke Conference

New cell therapy shows promise for critically ill COVID-19 patients with ARDS

Doppler ultrasound detects placental issues in small babies, study finds

New weight loss drug may be an effective strategy for preventing or treating high blood pressure

First gene therapy trial aims to restore hearing in children

PI3K/AKT and MEK/ERK pathways targeted in new therapy for docetaxel-resistant prostate cancer

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