Mouse Model News and Research

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New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing promising therapeutic drugs from those unlikely to be successful.

13 Dec 2018

Exercise may reduce colorectal cancer risk after weight loss

New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism.

13 Dec 2018

Baculovirus virion completely eliminates liver-stage parasites in mouse model

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasites, which can lay dormant for months or years as in the case of Plasmodium vivax. Researchers from Kanazawa University have successfully demonstrated that administration of a baculovirus virion completely eliminates liver-stage parasites in a mouse model via BV-induced fast-acting innate immunity.

13 Dec 2018

SLU researchers explore how fetal exposure to inflammation can alter immunity in newborns

Saint Louis University researchers are studying how fetal exposure to inflammation can alter immune responses after birth.

12 Dec 2018

Drug repositioning strategy identifies potential new treatments for epilepsy

Drug repositioning-- taking known drugs and identifying new applications for them--is an attractive concept for speeding up the process of bringing drugs to human testing for unmet medical needs.

11 Dec 2018

Breast tumors recruit bone marrow cells to boost their growth, study reveals

Tel Aviv University researchers have discovered that breast cancer tumors boost their growth by recruiting stromal cells that originate in bone marrow.

10 Dec 2018

MIT researchers develop antimicrobial peptides from South American wasp’s venom

The venom of insects such as wasps and bees is full of compounds that can kill bacteria. Unfortunately, many of these compounds are also toxic for humans, making it impossible to use them as antibiotic drugs.

7 Dec 2018

Elevated hormone flags liver disease in mice with serious genomic disorder

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder.

6 Dec 2018

Subset of immune B cells delays onset of type 1 diabetes in animal model

Researchers have conducted a study showing that a specific subset of immune B cells delays the onset of type 1 diabetes in mice.

6 Dec 2018

Mapping brain microglia

Microglia are known to be important to brain function. The immune cells have been found to protect the brain from injury and infection and are critical during brain development, helping circuits wire properly. They also seem to play a role in disease -- showing up, for example, around brain plaques in people with Alzheimer's.

6 Dec 2018

UAB research may point a path to more effective influenza vaccines

Seasonal influenza vaccines are typically less than 50 percent effective, according to Centers for Disease Control and Prevention studies. Research at the University of Alabama at Birmingham, published this week in Nature Immunology, may point a path to more effective vaccines.

6 Dec 2018

Scientists support original theory about pancreas regeneration

A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

5 Dec 2018

Eliminating microglia can reverse some aspects of stress sensitization, study shows

Using an animal model of chronic stress, researchers at The Ohio State University have shown that the immune cells of the brain, called microglia, hold unique signatures of chronic stress that leave the animal more sensitive to future stressful experiences, evident by increased anxiety and immune responses.

4 Dec 2018

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

In certain forms of cancer, connective tissue forms around and within the tumor. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumor in different ways.

4 Dec 2018

Customizing Genetically Engineered Models for Specific Research Applications

In this interview conducted at SfN 2018, Philip Dubé from Taconic Biosciences, goes into detail about genetically engineered models and their importance in understanding neurodegenerative diseases.

From Taconic Biosciences, Inc. 4 Dec 2018

Using nanocarrier-delivered microRNA to target sepsis

One in three patients who die in the U.S. dies of sepsis, according to the Centers for Disease Control and Prevention. It is one of the leading causes of death in intensive care units and, with an estimated price tag of $20 billion in 2011, the most expensive condition that hospitals treat.

3 Dec 2018

Scientists alleviate schizophrenic symptoms in mice

Despite extensive research efforts, schizophrenia remains one of the least understood brain disorders. One promising area of research is in receptors on the surfaces of brain cells that help sense growth factors.

30 Nov 2018

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

Adoptive cell transfer is a promising cancer immunotherapy that involves isolating T cells from cancer patients that are capable of targeting their tumor, selecting the more active T cells and expanding those in the lab, and then transfusing them back into patients.

30 Nov 2018

Curry spice may improve exercise intolerance related to heart failure

New research suggests that curcumin, a main ingredient in curry, may improve exercise intolerance related to heart failure. The study is published ahead of print in the Journal of Applied Physiology.

29 Nov 2018

New method could improve outcome of leukemia patients receiving stem-cell transplants

Stem-cell transplantation is an effective form of therapy to fight leukemia. In many cases, however, the transferred immune cells of the donor also attack the recipients' healthy tissue - often with fatal consequences.

28 Nov 2018