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Novel method for rapid incidence estimation from SARS-CoV-2 genomes

Daily counts of new COVID-19 cases remain a basis for evaluating the state of the pandemic and are vital for making informed decisions on public interventions.

15 Oct 2021

Phase 2 study shows safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine

The results of a phase 2 clinical trial featuring a SARS-CoV-2 recombinant protein vaccine developed by GlaxoSmithKline are reported, demonstrating a favorable immune response amongst both naïve and non-naïve adults with an acceptable safety profile.

15 Oct 2021

Cell-based quadrivalent influenza vaccine produces sufficient immune response in children

A cell-based influenza vaccine has effectively provided protection against the flu in children and adolescents, according to a new study.

15 Oct 2021

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

A new study reports a cell-based assay that involved the isolation and quantification of SARS-CoV-2 Mpro in human cells in the absence of other proteins.

14 Oct 2021

Increased transmission in open spike conformations of SARS-CoV-2 variants

Researchers from Yale University and the University of Texas have collaborated to investigate mutations in some VOCs.

14 Oct 2021

Mutation of cysteine residues in NRP1 reduces SARS-CoV-2 spike protein entry into cells

Researchers have been investigating altered protein conformations in variants of concern to provide further insight for future therapies against COVID-19.

14 Oct 2021

Small portion of COVID-19 patients infectious long-term

In late December 2019, a novel pneumonia-like lung infection was reported in the Chinese province of Hubei. This, in turn, led to the ongoing coronavirus disease-19 (COVID-19) pandemic. COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is closely related to SARS (Severe Acute Respiratory Syndrome) and MERS (the Middle East Respiratory Syndrome Coronavirus).

13 Oct 2021

Study identifies DNA mutations linking liver disease with obesity and diabetes

For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease.

13 Oct 2021

Genetic characteristics of possible new Alphacoronavirus species found in Bats

A recent study identifies a novel Alphacoronavirus isolated from bats, in Korea, in 2020.

13 Oct 2021

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Oncotarget published "Opposing effects of BRCA1 mRNA expression on patient survival in breast and colorectal cancer and variations among African American, Asian, and younger patients" which reported that LMNB2 is a chromatin remodeling protein that also plays a role in eukaryotic cell proliferation by organizing the nuclear membrane during mitosis.

13 Oct 2021

Women who carry a mutation in PALB2 gene more likely to be diagnosed with breast cancer

Most of us have heard about the BRCA1 and BRCA2 genes. Men and women with a personal and/or family history of breast cancer have been offered testing for mutations in these two genes for a number of years to determine if they are at greater risk for breast and other cancers.

12 Oct 2021

Single-genome sequencing reveals malaria parasite genetics and evolution

Understanding how malaria parasites evolve after a human is bitten by an infected mosquito is very difficult. There can be billions of individual parasites in a patient's bloodstream and traditional genetic sequencing techniques can't identify the raw material for evolution: new mutations.

12 Oct 2021

New source of stem cells could help treat people with Alagille syndrome

Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.

12 Oct 2021

Using genetic screening for selecting the 'best' embryo in IVF

Each year, tens of thousands of babies are born in the United States as the result of IVF (in vitro fertilization) – where several eggs are fertilized outside the mother's body and then an embryo is selected for transfer into her womb.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

Mutation News and Research

Novel method for rapid incidence estimation from SARS-CoV-2 genomes

Phase 2 study shows safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine

Cell-based quadrivalent influenza vaccine produces sufficient immune response in children

Study reveals a highly effective COVID-19 screening system utilizing a live cell-based assay

Increased transmission in open spike conformations of SARS-CoV-2 variants

Mutation of cysteine residues in NRP1 reduces SARS-CoV-2 spike protein entry into cells

Small portion of COVID-19 patients infectious long-term

Study identifies DNA mutations linking liver disease with obesity and diabetes

Genetic characteristics of possible new Alphacoronavirus species found in Bats

Impact of BRCA1 mRNA expression on survival of patients breast and colorectal cancer

Women who carry a mutation in PALB2 gene more likely to be diagnosed with breast cancer

Single-genome sequencing reveals malaria parasite genetics and evolution

New source of stem cells could help treat people with Alagille syndrome

Using genetic screening for selecting the 'best' embryo in IVF

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

New molecular understanding of variations in salmonella virulence

The role of inhibiting palmitoylation of the SARS-CoV-2 spike protein on viral infectivity

Vaccine-induced memory B cells can recognize SARS-CoV-2 variants

Accumulation of SARS-CoV-2 mutations reduces sensitivity to neutralizing antibodies

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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