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Influenza drug enisamium a potential COVID-19 treatment

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Jan 2021

CN Bio’s PhysioMimix technology receives FDA recognition

CN Bio today announced the publication of co-authored research with the U.S. Food and Drug Administration (FDA)1.

From CN Bio 12 Jan 2021

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer.

12 Jan 2021

Researchers study the behavior of regulatory T cells to understand periodontal disease

In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?

12 Jan 2021

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Now, a new preprint research paper published on the bioRxiv server shows how closely the antibodies formed in exposed humans resemble the germline antibody molecules. This could lead to the development of novel therapeutics to counter the pandemic.

12 Jan 2021

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Researchers in the United States have shown that extracts of an aromatic herb called Artemisia annua inhibit the replication of severe acute respiratory coronavirus (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

11 Jan 2021

Vimentin could be a major co-factor that aids SARS-CoV-2 infection

A recent study has found that extracellular vimentin can bind to SARS-CoV-2 spike protein in vitro, and antibodies against vimentin can decrease virus infectivity by up to 80%. This suggests vimentin could aid the virus’s binding to host cells and help in infection.

11 Jan 2021

Mogrify enters research collaboration with the MRC Laboratory of Molecular Biology

Mogrify Limited and the MRC Laboratory of Molecular Biology (LMB), today announced an exploratory research collaboration.

11 Jan 2021

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Like Peter Pan, some cells never grow up. In cancer, undifferentiated stem cells may help tumors such as glioblastoma become more aggressive than other forms of the disease.

8 Jan 2021

Wireless medical device might help with weight loss

Gastric bypass surgery is sometimes the last resort for those who struggle with obesity or have serious health-related issues due to their weight.

8 Jan 2021

Are SARS-CoV-2 antibodies associated with disease enhancement?

As SARS-CoV-2 continues to wreak its havoc, antibodies that neutralize the virus and protect against infection have become an important focus of research. However, there is a concern as to whether these antibodies can actually enhance the disease.

6 Jan 2021

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue.

5 Jan 2021

Replacing the RNA strand with DNA may enhance efficacy of ASO-based drugs

Antisense oligonucleotides (ASO) hold great promise for pharmacotherapy. Now, researchers at Tokyo Medical and Dental University (TMDU) and Ionis Pharmaceuticals, advancing their earlier work on a heteroduplex oligonucleotide (HDO) model, have demonstrated augmentation of ASO-based drugs by replacing the RNA strand with DNA.

5 Jan 2021

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues.

5 Jan 2021

P2 COVID-19 study shows no material safety differences between opaganib and control arms

Preliminary data from the non-powered U.S. Phase 2 study of 40 hospitalized patients shows that orally-administered opaganib was safe, with no material safety differences between opaganib and control arms.

4 Jan 2021

New device for investigating intrinsic extracellular pH dynamics in the brain

Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

As the world struggles to contain the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for over 1.6 million deaths and 76 million infections globally, researchers are trying to pin down the determinants of lethality, of infectivity and of protection. Such data would help contain its spread and develop preventive and therapeutic antivirals and vaccines. A new preprint that appeared recently on the bioRxiv* server describes the high degree of protection afforded by antibodies that target the N-terminal domain (NTD) of the virus.

24 Dec 2020

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Researchers at Tohoku University have developed the first all-in-one miniature pH probe for real-time investigations of intrinsic extracellular pH dynamics in the deep brain structures.

24 Dec 2020

Researchers use fruit fly model to understand COVID-19-related neurological complications

Researchers claim to have reproduced disease mechanisms due to coronavirus disease 2019 (COVID-19) in the fruit fly, Drosophila, while also providing proof of the efficacy of one drug against these disease processes. If validated, these findings represent a new understanding of how the virus causes neurological symptoms that could help develop more effective therapies.

23 Dec 2020

in vivo News and Research

Influenza drug enisamium a potential COVID-19 treatment

CN Bio’s PhysioMimix technology receives FDA recognition

ARID1A gene in ovarian cancer plays a role in the regulation of metabolism

Researchers study the behavior of regulatory T cells to understand periodontal disease

Discovery of SARS-CoV-2 neutralizing antibodies from a naïve human Ab library

Extract of medicinal plant Artemisia annua interferes with replication of SARS-CoV-2 in vitro

Vimentin could be a major co-factor that aids SARS-CoV-2 infection

Mogrify enters research collaboration with the MRC Laboratory of Molecular Biology

Nuclear DICER complex disrupts cytoplasmic microRNAome in glioblastoma cancer cells

Wireless medical device might help with weight loss

Are SARS-CoV-2 antibodies associated with disease enhancement?

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Replacing the RNA strand with DNA may enhance efficacy of ASO-based drugs

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

P2 COVID-19 study shows no material safety differences between opaganib and control arms

New device for investigating intrinsic extracellular pH dynamics in the brain

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

Miniature pH probe allows real-time analysis of pH dynamics in deep brain structures

Researchers use fruit fly model to understand COVID-19-related neurological complications

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

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The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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