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Antibiotic stewardship programs help long-term care facilities to reduce unnecessary antibiotic use

In early 2021, researchers at Johns Hopkins Medicine and NORC at the University of Chicago showed that the Agency for Healthcare Research and Quality (AHRQ) Safety Program for Improving Antibiotic Use — a comprehensive system they developed to assist health care institutions with establishing and operating antibiotic stewardship programs (ASPs) — successfully helped more than 400 U.S. hospitals ensure that patients only received antibiotics when needed, and then, only in the correct amounts and for the prescribed dosage period.

28 Feb 2022

Scientists investigate the antiviral properties of cow milk protein against SARS-CoV-2 variants

As the COVID-19 pandemic continues to claim lives around the world, dairy scientists may have a surprising role to play. In a new report published in the Journal of Dairy Science, scientists from the University of Michigan (Ann Arbor, MI, USA) and Glanbia PLC Research and Development (Twin Falls, ID, USA) have collaborated to investigate the antiviral properties of cow milk protein against variants of SARS-CoV-2, the virus behind the illness.

28 Feb 2022

Outpatient antibiotic treatment for infective endocarditis improves outcomes, reduces costs

A new modeling study suggests that when patients who inject opioids continue an antibiotic treatment for infective endocarditis outside of the hospital, they experienced better long-term health outcomes than patients who receive the standard four to six weeks of inpatient, intravenous antibiotic therapy.

28 Feb 2022

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Researchers evaluated the pathogenicity and replication potential of SARS-CoV-2 VOC Omicron lineage, BA.2 in immunocompetent mice and hamsters.

28 Feb 2022

Antibiotics provide no benefit in preventing recurrent wheezing in infants hospitalized with RSV

Antibiotics provide no benefit in preventing future recurrent wheezing in babies hospitalized with respiratory syncytial virus (RSV), according to a new study led by Washington University School of Medicine in St. Louis. And there is some evidence that antibiotics may make wheezing worse.

27 Feb 2022

Clinical trial shows encouraging results with fecal microbiota transplants for peanut-allergic patients

Peanut allergies are hard to treat and can cause fatal or near-fatal anaphylactic reactions. People usually don't outgrow peanut allergy, requiring lifelong scrutiny of food labels to avoid even small traces of peanut.

27 Feb 2022

Oral health disparities persist and pose a major global public health threat, experts say

Americans' oral health has improved over the last two decades, but disparities in oral health have stubbornly persisted and pose a major global public health threat, write National Institute of Dental and Craniofacial Research Director Rena N. D'Souza, D.D.S., Ph.D., Science Advisor to the President and former National Institutes of Health Director Francis S. Collins, M.D., Ph.D., and U.S. Surgeon General Vivek H. Murthy, M.D., M.B.A., in a new perspective published in The New England Journal of Medicine.

27 Feb 2022

Rarely-used antibiotic could be a safe and affordable treatment for neonatal sepsis

An antibiotic rarely used in infants admitted to hospitals could be a safe and affordable, life-saving treatment for neonatal sepsis, in the face of growing resistance to other drugs, a study finds.

24 Feb 2022

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Insilico Medicine, an end-to-end artificial intelligence (AI)-driven drug discovery company, today announced that it has dosed multiple healthy volunteers in Phase I clinical trial evaluating ISM001-055, the first anti-fibrotic small molecule inhibitor generated by Insilico's AI-powered drug discovery platform for idiopathic pulmonary fibrosis (IPF).

24 Feb 2022

Study provides a promising new avenue for development of anti-obesity treatments

An anti-tumor drug promotes weight loss in mice at low doses by activating a natural hunger-suppressing pathway, according to a new study publishing February 24th in the open-access journal PLOS Biology by Jiang Wei Wu and colleagues at Northwest A&F University in Shaanxi, China.

24 Feb 2022

Edible egg-derived IgY antibodies against SARS-CoV-2 Omicron

A new study posted to the bioRxiv* preprint server reports on the development of anti-RBD immunoglobulin Y (IgY) antibodies from chicken eggs to block the binding of the viral RBD to human ACE2 receptors. This approach has several advantages since chicken egg-derived IgY can be edible and polyclonal can target multiple epitopes, enhancing neutralizing activity.

23 Feb 2022

SARS-Cov-2 reinfection in Syrian hamsters does not result in disease

Researchers have been investigating the reinfection of different SARS-CoV-2 variants in Syrian hamsters and found that this does not seem to result in disease or any significant pulmonary pathology.

23 Feb 2022

Study of dental hygienists shows the profound impact of COVID-19 on clinical practice

Nearly two years into the pandemic with widespread availability of COVID-19 vaccines and a decrease in infections, new studies reveal dental hygienists have low COVID-19 infection rates and high vaccination acceptance.

22 Feb 2022

New studies highlight how e-cigarettes may be contributing to gum disease

A series of new studies by researchers at NYU College of Dentistry highlights how e-cigarettes alter oral health and may be contributing to gum disease.

22 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

Benchmarking models of SARS-CoV-2 transmission through aerosols and droplets

A new study generated a consolidated set of parameters involving the exhalation of particles.

20 Feb 2022

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

Results from an international, randomized, double-blind, placebo-controlled, phase 3 clinical trial indicate that adding the androgen-receptor inhibitor darolutamide to androgen-deprivation therapy and chemotherapy prolongs the survival of men with metastatic, hormone-sensitive prostate cancer, a disease that is fatal in most cases.

18 Feb 2022

SARS-CoV-2 Mpro inhibitor, nirmatrelvir, found to reduce COVID-19 progression and death

In a new study, researchers evaluated the efficacy and safety of nirmatrelvir in mild to moderate COVID-19 patients who were at high risk of severe COVID-19 disease.

18 Feb 2022

Trial of early antiviral therapy for COVID-19 shows no significant benefit

A new preprint research paper examines the efficacy of using three antivirals in various combinations in early infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Feb 2022

Oral News and Research

Antibiotic stewardship programs help long-term care facilities to reduce unnecessary antibiotic use

Scientists investigate the antiviral properties of cow milk protein against SARS-CoV-2 variants

Outpatient antibiotic treatment for infective endocarditis improves outcomes, reduces costs

Study finds Omicron sublineage BA.2 is less pathogenic in rodent models than prior SARS-CoV-2 variants

Antibiotics provide no benefit in preventing recurrent wheezing in infants hospitalized with RSV

Clinical trial shows encouraging results with fecal microbiota transplants for peanut-allergic patients

Oral health disparities persist and pose a major global public health threat, experts say

Rarely-used antibiotic could be a safe and affordable treatment for neonatal sepsis

Phase I clinical trial evaluates AI-discovered first anti-fibrotic small molecule inhibitor

Study provides a promising new avenue for development of anti-obesity treatments

Edible egg-derived IgY antibodies against SARS-CoV-2 Omicron

SARS-Cov-2 reinfection in Syrian hamsters does not result in disease

Study of dental hygienists shows the profound impact of COVID-19 on clinical practice

New studies highlight how e-cigarettes may be contributing to gum disease

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Benchmarking models of SARS-CoV-2 transmission through aerosols and droplets

Combination of three drugs extends the survival of patients with metastatic, hormone-sensitive prostate cancer

SARS-CoV-2 Mpro inhibitor, nirmatrelvir, found to reduce COVID-19 progression and death

Trial of early antiviral therapy for COVID-19 shows no significant benefit

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