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Children's Hospital of Philadelphia invited to Obama's announcement of Precision Medicine Initiative

At the invitation of the White House, The Children's Hospital of Philadelphia (CHOP) sent two special guests to President Barack Obama's announcement today of the Precision Medicine Initiative: Dr. Steven M. Altschuler, CHOP's chief executive officer, and 9-year-old patient Emily Whitehead, now cancer-free thanks to a personalized treatment called T cell therapy, developed at CHOP.

2 Feb 2015

Mylan signs definitive agreement to acquire Famy Care's female health care businesses

Mylan Inc. today announced that it has, through its Indian subsidiary Mylan Laboratories Limited, signed a definitive agreement to acquire certain female health care businesses from Famy Care Limited, a specialty women's health care company with global leadership in generic oral contraceptive products (OCPs) for $750 million in cash plus additional contingent payments of up to $50 million.

2 Feb 2015

Mathematical models of cancer behavior offer new insights on tumor growth

Hassan Fathallah-Shaykh, M.D., Ph.D., believes that math can transform medicine, and he has the numbers to prove it.

2 Feb 2015

ABIVAX doses first HIV positive patient in ABX464 Phase IIa clinical trial

ABIVAX, a leading clinical stage biotech company developing and commercialising anti-viral compounds and human vaccines, today announced that enrolment has been initiated and the first HIV positive patient dosed in a Phase IIa clinical trial of ABX464.

2 Feb 2015

Drug-resistant HIV viruses can spread rapidly, shows study

Drug-resistant HIV viruses can spread rapidly. This is the conclusion of a study conducted as part of the SWISS HIV Cohort Study, which is supported by the SNSF. Only the continuous introduction of new drugs can stop the virus from getting the upper hand.

2 Feb 2015

New protocol promises to transform remote monitoring of patients through implanted medical sensors

The ageing of society needs new, more cost-effective solutions to improve the life quality of patients and cut the burden that is placed on the social welfare system.

2 Feb 2015

Exploring better treatment for adolescent idiopathic scoliosis

Adolescent idiopathic scoliosis (AIS) affects 2-3% of children aged between 10 and 16. It is more common in girls than in boys (with a ratio of 10-1). Besides the obvious physical signs derived from the visible spinal deformity, AIS can cause psychological and emotional problems (low self-esteem, poor self-image body, etc.) that significantly reduces patients' quality of life.

31 Jan 2015

No single global optimal solution for deimmunization of a given biotherapeutic agent

By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, Dartmouth's Norris Cotton Cancer Center investigator Karl Griswold, PhD, and his collaborator Chris Bailey-Kellogg, PhD, have established a novel testing platform.

31 Jan 2015

Study explores gender identity in transgender children

A study with 32 transgender children, ages 5 to 12, indicates that the gender identity of these children is deeply held and is not the result of confusion about gender identity or pretense.

31 Jan 2015

TSRI researchers awarded grant to develop novel method for detecting DNA damage in stem cells

A team at The Scripps Research Institute has won a $1,784,000 grant from the California Institute for Regenerative Medicine (CIRM). The funding will support the development of a new method for detecting DNA damage in stem cells to ensure that only the highest quality cells are used in transplantation or therapy.

31 Jan 2015

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers Irving L. Weissman and Joan Massagué have won this year's Charles Rodolphe Brupbacher Prize for Cancer Research: Weissman, from Stanford University, for his work on healthy and sick stem cells; Massagué, from Memorial Sloan Kettering Cancer Center in New York, for his research on metastatic spread.

31 Jan 2015

Project Spark to advance neuroprotective drug for schizophrenia-associated cognitive impairment

A public-private consortium led by the biotech Iproteos -based at Parc Científic de Barcelona (PCB)-, and comprised by the biopharmaceutical company Ascil-Biopharma, the Institute for Biomedical Research (IRB Barcelona), the Centre for Genomic Regulation (CRG) and the University of the Basque Country (UPV/EHU) has launched a project to advance the development of a new neuroprotective drug for the treatment of the cognitive impairment associated with schizophrenia and other mental disorders.

31 Jan 2015

MD Anderson and AstraZeneca to conduct multiple studies in ovarian, gynecologic cancers

The University of Texas MD Anderson Cancer Center and AstraZeneca today announced a multiyear strategic research collaboration to conduct multiple, parallel clinical and clinically related studies in ovarian and other gynecologic cancers with the aim of improving patient outcomes.

31 Jan 2015

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

31 Jan 2015

FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

The U.S. Food and Drug Administration approval of ibrutinib (Imbruvica) to treat patients with Waldenstrom's macroglobulinemia(WM) is a significant advance for patients with this rare blood cancer.

31 Jan 2015

Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

For the first time, scientists have revealed a mechanism underlying the cellular degeneration of upper motor neurons, a small group of neurons in the brain recently shown to play a major role in ALS pathology.

31 Jan 2015

TCGA researchers uncover differences between tumors with and without HPV infection

The study by The Cancer Genome Atlas (TCGA) researchers analyzed the genomes of 279 head and neck cancer tumors. They identified subtypes of head and neck cancer based on their genomic characteristics, changes in smoking-related tumors, as well as genomic differences in head and neck cancer tumors linked to HPV, the most commonly sexually transmitted disease in the United States.

31 Jan 2015

AbbVie releases Phase 3 results from all-oral OBV/PTV/r treatment for GT1b chronic HCV infection

AbbVie released top-line Phase 3 results for its investigational, all-oral, ribavirin (RBV)-free, two direct-acting antiviral treatment with ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) in patients with genotype 1b (GT1b) chronic hepatitis C virus (HCV) infection in Japan.

31 Jan 2015

Temple University Hospital participating in trial to test vibrating capsule for chronic constipation treatment

Chronic constipation is a common problem that affects approximately 15 percent of the U.S. population, according to the American Gastroenterological Association. It can be painful and lead to a reduction in a patient's quality of life. Temple University Hospital is the only hospital in the Philadelphia region participating in a nationwide clinical trial to test an innovative, vibrating capsule for patients with chronic constipation.

31 Jan 2015

Scientists identify strong link between beclin 1 gene and triple-negative breast cancer

UT Southwestern Medical Center scientists have identified a strong link between the most aggressive type of breast cancer and a gene that regulates the body's natural cellular recycling process, called autophagy.

30 Jan 2015

Therapy News and Research

Children's Hospital of Philadelphia invited to Obama's announcement of Precision Medicine Initiative

Mylan signs definitive agreement to acquire Famy Care's female health care businesses

Mathematical models of cancer behavior offer new insights on tumor growth

ABIVAX doses first HIV positive patient in ABX464 Phase IIa clinical trial

Drug-resistant HIV viruses can spread rapidly, shows study

New protocol promises to transform remote monitoring of patients through implanted medical sensors

Exploring better treatment for adolescent idiopathic scoliosis

No single global optimal solution for deimmunization of a given biotherapeutic agent

Study explores gender identity in transgender children

TSRI researchers awarded grant to develop novel method for detecting DNA damage in stem cells

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Project Spark to advance neuroprotective drug for schizophrenia-associated cognitive impairment

MD Anderson and AstraZeneca to conduct multiple studies in ovarian, gynecologic cancers

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

TCGA researchers uncover differences between tumors with and without HPV infection

AbbVie releases Phase 3 results from all-oral OBV/PTV/r treatment for GT1b chronic HCV infection

Temple University Hospital participating in trial to test vibrating capsule for chronic constipation treatment

Scientists identify strong link between beclin 1 gene and triple-negative breast cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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