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New bacterial species may help fight obesity and metabolic disorders

The MyNewGut project has discovered new bacterial species and strains in healthy people that seem to be effective against obesity, metabolic and mental disorders related to stress and obesity (e.g. depression).

17 Dec 2018

Recurrence of urinary tract infection may depend on bacterial strain, study shows

Genetically diverse bacterial strains that cause urinary tract infections differ in their ability to trigger protective immune responses in mice, potentially explaining why these infections frequently recur in many patients, according to a study published December 13 in the open-access journal PLOS Pathogens by Thomas Hannan and Scott Hultgren of Washington University School of Medicine, and colleagues.

14 Dec 2018

New findings could help develop new immunotherapies against cancer

NK cells, or natural killer cells, play an important role in the body's defences against cancer and various infections.

14 Dec 2018

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Using a mouse model of necrotizing enterocolitis -- a potentially fatal condition that causes a premature infant's gut to suddenly die -- researchers at Johns Hopkins say they have uncovered the molecular causes of the condition and its associated brain injury.

14 Dec 2018

Scientists develop new stem cell line to study conversion of stem cells into muscle

To help patients with muscle disorders, scientists at The University of Texas Health Science Center at Houston (UTHealth) have engineered a new stem cell line to study the conversion of stem cells into muscle. Findings appeared in Cell Reports.

13 Dec 2018

Study: Loss of tight junction barrier protein results in gastric cancer development

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer.

13 Dec 2018

New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing promising therapeutic drugs from those unlikely to be successful.

13 Dec 2018

Exercise may reduce colorectal cancer risk after weight loss

New research suggests that exercise is a key factor in reducing colorectal cancer risk after weight loss. According to the study, physical activity causes beneficial changes in the bone marrow. The study is published ahead of print in the American Journal of Physiology--Endocrinology and Metabolism.

13 Dec 2018

Baculovirus virion completely eliminates liver-stage parasites in mouse model

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasites, which can lay dormant for months or years as in the case of Plasmodium vivax. Researchers from Kanazawa University have successfully demonstrated that administration of a baculovirus virion completely eliminates liver-stage parasites in a mouse model via BV-induced fast-acting innate immunity.

13 Dec 2018

SLU researchers explore how fetal exposure to inflammation can alter immunity in newborns

Saint Louis University researchers are studying how fetal exposure to inflammation can alter immune responses after birth.

12 Dec 2018

Drug repositioning strategy identifies potential new treatments for epilepsy

Drug repositioning-- taking known drugs and identifying new applications for them--is an attractive concept for speeding up the process of bringing drugs to human testing for unmet medical needs.

11 Dec 2018

Breast tumors recruit bone marrow cells to boost their growth, study reveals

Tel Aviv University researchers have discovered that breast cancer tumors boost their growth by recruiting stromal cells that originate in bone marrow.

10 Dec 2018

MIT researchers develop antimicrobial peptides from South American wasp’s venom

The venom of insects such as wasps and bees is full of compounds that can kill bacteria. Unfortunately, many of these compounds are also toxic for humans, making it impossible to use them as antibiotic drugs.

7 Dec 2018

Elevated hormone flags liver disease in mice with serious genomic disorder

Researchers have discovered that a hormone, fibroblast growth factor 21 (FGF21), is extremely elevated in mice with liver disease that mimics the same condition in patients with methylmalonic acidemia (MMA), a serious genomic disorder.

6 Dec 2018

Subset of immune B cells delays onset of type 1 diabetes in animal model

Researchers have conducted a study showing that a specific subset of immune B cells delays the onset of type 1 diabetes in mice.

6 Dec 2018

Mapping brain microglia

Microglia are known to be important to brain function. The immune cells have been found to protect the brain from injury and infection and are critical during brain development, helping circuits wire properly. They also seem to play a role in disease -- showing up, for example, around brain plaques in people with Alzheimer's.

6 Dec 2018

UAB research may point a path to more effective influenza vaccines

Seasonal influenza vaccines are typically less than 50 percent effective, according to Centers for Disease Control and Prevention studies. Research at the University of Alabama at Birmingham, published this week in Nature Immunology, may point a path to more effective vaccines.

6 Dec 2018

Scientists support original theory about pancreas regeneration

A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how.

5 Dec 2018

Eliminating microglia can reverse some aspects of stress sensitization, study shows

Using an animal model of chronic stress, researchers at The Ohio State University have shown that the immune cells of the brain, called microglia, hold unique signatures of chronic stress that leave the animal more sensitive to future stressful experiences, evident by increased anxiety and immune responses.

4 Dec 2018

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

In certain forms of cancer, connective tissue forms around and within the tumor. One previously unproven theory is that there are several different types of connective tissue cells with different functions, which affect the development of the tumor in different ways.

4 Dec 2018

Mouse Model News and Research

New bacterial species may help fight obesity and metabolic disorders

Recurrence of urinary tract infection may depend on bacterial strain, study shows

New findings could help develop new immunotherapies against cancer

Johns Hopkins researchers identify molecular causes of necrotizing enterocolitis in preemies

Scientists develop new stem cell line to study conversion of stem cells into muscle

Study: Loss of tight junction barrier protein results in gastric cancer development

New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

Exercise may reduce colorectal cancer risk after weight loss

Baculovirus virion completely eliminates liver-stage parasites in mouse model

SLU researchers explore how fetal exposure to inflammation can alter immunity in newborns

Drug repositioning strategy identifies potential new treatments for epilepsy

Breast tumors recruit bone marrow cells to boost their growth, study reveals

MIT researchers develop antimicrobial peptides from South American wasp’s venom

Elevated hormone flags liver disease in mice with serious genomic disorder

Subset of immune B cells delays onset of type 1 diabetes in animal model

Mapping brain microglia

UAB research may point a path to more effective influenza vaccines

Scientists support original theory about pancreas regeneration

Eliminating microglia can reverse some aspects of stress sensitization, study shows

Researchers find two connective tissue cells to be linked to worse prognosis of breast cancer

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