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Study provides new clues to origin and development of multiple sclerosis

Mapping of a certain group of cells, known as oligodendrocytes, in the central nervous system of a mouse model of multiple sclerosis, shows that they might have a significant role in the development of the disease.

12 Nov 2018

Study shows novel strategy to reduce breast cancer bone metastasis

Uncovering a novel mechanism that promotes growth of breast cancer bone metastasis has revealed a potential Achilles' heel for these cancer cells. Reported in the journal Cancer Cell, the study shows that interfering with this mechanism can reduce the risk of relapses in animal models.

12 Nov 2018

Failed DNA repair triggers chromosomal chaos in cancer cells

Researchers have established the trigger for catastrophic events that occur within the chromosomes of cancer cells and lead to cancer cell death.

12 Nov 2018

Scientists solve 125-year-old mystery of the brain, uncover potential treatment for epilepsy

Scientists at the Virginia Tech Carilion Research Institute have solved a 125-year-old mystery of the brain, and, in the process, uncovered a potential treatment for acquired epilepsy.

9 Nov 2018

Newly designed mice emulate severe form of kidney damage in humans with diabetes

Scientists led by Duke-NUS Medical School have designed mice that successfully emulate a severe form of kidney damage in humans with diabetes, called diabetic nephropathy.

9 Nov 2018

B cell accumulation triggers nervous system damage in MS

B cells are important in helping the immune system fight pathogens. However, in the case of the neurological autoimmune disease Multiple Sclerosis (MS) they can damage nerve tissue.

8 Nov 2018

Circadian clock could play key role in the fight against liver cancer

The body's internal clock could play a critical role in the fight against certain types of liver cancer, according to a preclinical study by scientists from The University of Texas Health Science Center at Houston (UTHealth). The results were published recently in the journal Nature Communications.

8 Nov 2018

New nano-immunotherapy promotes long-term acceptance of transplanted organs

Researchers at the Mount Sinai School of Medicine have developed a new nanotechnology-based immunotherapy that promotes long-term transplant acceptance in an animal model.

7 Nov 2018

Study pinpoints two proteins that sense blood pressure and help control baroreceptor reflex

The baroreceptor reflex is a fascinating medical phenomenon. The reflex is controlled by specialized neurons that react in just a fraction of a second to keep blood pressure fairly consistent.

30 Oct 2018

Using genome editing to prevent sudden cardiac death

Each year, at least 3 million people worldwide die of sudden cardiac death. In the U.S., this number reaches up to 450,000 people.

30 Oct 2018

Ten Allen Distinguished Investigators for 2018 announced by Paul G. Allen Frontiers Group

Nanoparticles that could reprogram a cancer patient's immune system inside their own body. Understanding a mysterious type of brain cell in the hopes of shedding new light on Alzheimer's disease. Reimagining nuclei, the DNA-storage compartments of our cells, as miniature lava lamps.

30 Oct 2018

Forced expression of a natural protein reduces fat in mice by a third

In a mouse model of obesity, forced expression of the protein FGFBP3 (BP3 for short) significantly reduced the animals’ fat mass.

29 Oct 2018

New approach may lead to protective vaccines for immunocompromised patients

A study led by Som Nanjappa at the University of Illinois College of Veterinary Medicine identifies a cellular target that may improve efficacy in vaccines designed to protect immunocompromised individuals from potentially deadly opportunistic infections.

26 Oct 2018

Potential new biomarkers may aid early detection of glaucoma

Researchers at Ruhr-Universität Bochum have identified new potential biomarkers that may facilitate early detection of glaucoma in patients. Moreover, they ascertained that the mutation of a certain gene in mice causes intraocular pressure elevation.

25 Oct 2018

Researchers reach new milestone in understanding muscle formation

Researchers from the Randall Centre for Cell & Molecular Biophysics believe they have reached a new milestone in the understanding of muscle formation that could help define new cellular and molecular approaches in pathological conditions affecting muscle wellness.

24 Oct 2018

Neurons in the brain's primary visual cortex can reliably detect straight lines

Single neurons in the brain's primary visual cortex can reliably detect straight lines, even though the cellular makeup of the neurons is constantly changing, according to a new study by Carnegie Mellon University neuroscientists, led by Associate Professor of Biological Sciences Sandra Kuhlman.

24 Oct 2018

Salk researchers advance sonogenetics technology for treating neurological conditions

The emerging technology of sonogenetics--a technique where cells are controlled by sound--offers the potential to one day replace pharmaceutical drugs or invasive surgical treatments for neurological conditions like epilepsy, Parkinson's disease or posttraumatic stress disorder.

23 Oct 2018

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Researchers from The Ottawa Hospital and the University of Ottawa have developed a promising targeted strategy to treat chemotherapy-resistant acute myeloid leukemia and a diagnostic test to determine which AML patients would most likely benefit from this treatment.

22 Oct 2018

Paternal exercise has significant impact on child's lifelong metabolic health

Recent studies have linked development of type 2 diabetes and impaired metabolic health individuals to their parents' poor diet, and there is increasing evidence that fathers play an important role in obesity and metabolic programming of their offspring.

22 Oct 2018

Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia

Innovative cardioprotective strategies are of imminent demand. Nonfatal myocardial ischemia (MI) poses a significant risk to patients undergoing major non-cardiac surgery and these non-cardiac surgeries account for around 8 million myocardial injuries per year

19 Oct 2018

Mouse Model News and Research

Study provides new clues to origin and development of multiple sclerosis

Study shows novel strategy to reduce breast cancer bone metastasis

Failed DNA repair triggers chromosomal chaos in cancer cells

Scientists solve 125-year-old mystery of the brain, uncover potential treatment for epilepsy

Newly designed mice emulate severe form of kidney damage in humans with diabetes

B cell accumulation triggers nervous system damage in MS

Circadian clock could play key role in the fight against liver cancer

New nano-immunotherapy promotes long-term acceptance of transplanted organs

Study pinpoints two proteins that sense blood pressure and help control baroreceptor reflex

Using genome editing to prevent sudden cardiac death

Ten Allen Distinguished Investigators for 2018 announced by Paul G. Allen Frontiers Group

Forced expression of a natural protein reduces fat in mice by a third

New approach may lead to protective vaccines for immunocompromised patients

Potential new biomarkers may aid early detection of glaucoma

Researchers reach new milestone in understanding muscle formation

Neurons in the brain's primary visual cortex can reliably detect straight lines

Salk researchers advance sonogenetics technology for treating neurological conditions

Researchers develop promising targeted strategy to treat chemo-resistant blood cancer

Paternal exercise has significant impact on child's lifelong metabolic health

Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia

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