Proliferation News and Research

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Sophisticated 'social control' system allows embryos to protect purity of pluripotent cell population

A sophisticated system of 'social control' operating between neighboring cells allows embryos to protect the purity of their pluripotent cell population, which is able to generate all body tissues.

27 Sep 2017

Study: Gene linked to schizophrenia risk controls early neurodevelopment

A gene associated with the risk of schizophrenia regulates critical components of early brain development, according to a new study led by researchers from Penn State University.

26 Sep 2017

Study presents new method for tracing history of β-cells

Tracing the history of individual cells in the developing organism can reveal functional differences among seemingly uniform cells. This knowledge is important for defining the characteristics of highly regenerative cells in order to target them for cellular therapies, as well as to prevent the formation of unfit cells, which compromise the overall health of the organism.

22 Sep 2017

Researchers identify molecular pathway that causes immune cells to promote cancer

Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles have identified new findings about an immune cell - called a tumor-associated macrophage - that promotes cancer instead of fighting it.

21 Sep 2017

Researchers identify new genetic test to help predict cancer recurrence

Researchers have discovered a new genetic test which could help predict cancer recurrence - paving the way for more precise, personalized treatments.

21 Sep 2017

Study identifies slowly proliferating and highly invasive melanoma cells

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior. The research was published in the journal Oncogene.

21 Sep 2017

Regeneration ability may lie with the body's innate immune system, study shows

The answer to regenerative medicine's most compelling question -- why some organisms can regenerate major body parts such as hearts and limbs while others, such as humans, cannot -- may lie with the body's innate immune system, according to a new study of heart regeneration in the axolotl, or Mexican salamander, an organism that takes the prize as nature's champion of regeneration.

21 Sep 2017

Study overturns common belief about how proteins regulate formation of sensory interneurons

A recent study led by Samantha Butler at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA has overturned a common belief about how a certain class of proteins in the spinal cord regulate the formation of nervous system cells -- called neurons -- during embryonic development.

19 Sep 2017

Epidemiologist to advance research on hormonal markers for better prediction of breast cancer risk

Epidemiologist Susan Hankinson at the University of Massachusetts Amherst has received a five-year, $4.2 million grant from the National Cancer Institute to build upon and advance her research group's earlier work to identify and validate hormonal markers to better predict the risk of invasive breast cancer in postmenopausal women.

19 Sep 2017

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

The discovery of a mechanism by which normal brain cells regulate the expression of the NFIA gene, which is important for both normal brain development and brain tumor growth, might one day help improve therapies to treat brain tumors. The study appears in the journal Nature Neuroscience.

13 Sep 2017

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a potential strategy for improving the efficacy of angiogenesis inhibitors, drugs that help fight cancer by blocking the formation of new blood vessels.

13 Sep 2017

Seeing the full picture, real-time analysis of live-cells

Every cell is a miniature factory taking in raw material (extracellular signals) and processing it to produce something (a biological response). But unlike a factory that can be easily tweaked to run at steady-state and look the same from day to day, cells are dynamic.

From Sartorius 7 Sep 2017

Study describes link between key melanoma signaling pathway and novel class of drugs

Results of a study by The Wistar Institute have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this type of treatment.

7 Sep 2017

Researchers identify gene variants linked to both type 2 diabetes and CHD risk

Type 2 diabetes (T2D) has become a global epidemic affecting more than 380 million people worldwide; yet there are knowledge gaps in understanding the etiology of type-2 diabetes.

4 Sep 2017

FDA approves first cell-based gene therapy for use in the United States

The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.

30 Aug 2017

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

New blood vessels branch out of preexisting ones is via a process called angiogenesis. Although this is essential for survival, development and wound healing, on the flip side, it also feeds and progresses malignant tumors, as well as other diseases.

29 Aug 2017

Targeting bone marrow protein could be effective way to improve stem cell transplants

Bone marrow contains hematopoetic stem cells, the precursors to every blood cell type. These cells spring into action following bone marrow transplants, bone marrow injury and during systemic infection, creating new blood cells, including immune cells, in a process known as hematopoiesis.

28 Aug 2017

Proliferation News and Research

Sophisticated 'social control' system allows embryos to protect purity of pluripotent cell population

Study: Gene linked to schizophrenia risk controls early neurodevelopment

Study presents new method for tracing history of β-cells

Researchers identify molecular pathway that causes immune cells to promote cancer

Researchers identify new genetic test to help predict cancer recurrence

Study identifies slowly proliferating and highly invasive melanoma cells

Regeneration ability may lie with the body's innate immune system, study shows

Study overturns common belief about how proteins regulate formation of sensory interneurons

Epidemiologist to advance research on hormonal markers for better prediction of breast cancer risk

Disrupting DNA loops could be potential strategy to reduce tumor proliferation

MGH researchers identify potential strategy for improving efficacy of angiogenesis inhibitors

Seeing the full picture, real-time analysis of live-cells

Study describes link between key melanoma signaling pathway and novel class of drugs

Researchers identify gene variants linked to both type 2 diabetes and CHD risk

FDA approves first cell-based gene therapy for use in the United States

IBS scientists uncover key regulator of normal as well as pathological angiogenesis

Targeting bone marrow protein could be effective way to improve stem cell transplants

Study shows previously unknown dimension of lymphangiogenesis during worm infection

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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