Mutation News and Research

RSS

Trial of Sanofi/GSK SARS-CoV-2 vaccine boosters against variants in non-human primates

New research discusses the development of soluble prefusion-stabilized spike trimers (CoV2 preS dTM) comprising adjuvant AS03.

27 Sep 2021

A new SARS-CoV-2 variant (B.1.1.523) capable of escaping immune protections

A new study describes a new variant that possesses a novel combination of various concerning mutations at the spike region.

27 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Characterization of SARS-CoV-2 infections diagnosed after mRNA BNT162b2 vaccination

A team from the National Institute for Infectious Diseases “L. Spallanzani” (INMI) has recently reported their study on 94 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections (47.9% symptomatic, 52.1% asymptomatic) that occurred after the first or second vaccine dose against SARS-CoV-2 in the Lazio region (Central Italy).

27 Sep 2021

Study reveals surfaces of SARS-CoV-2 spike most resistant to antibody escape

A team of international scientists has formed a consortium to map the epitope landscape of a range of therapeutic monoclonal antibodies on the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the scientists characterized the neutralization potency of these antibodies and have investigated how emerging viral variants with spike mutations can impact antibody-mediated neutralization. They have recently published the consortium findings in the journal Science.

27 Sep 2021

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Twist Bioscience Corporation (Nasdaq: TWST) today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19.

25 Sep 2021

Promising data from early clinical trials of new anticancer therapies presented at ESMO Congress 2021

Data from early clinical trials presented at the ESMO Congress 2021 suggest that new anticancer treatments are on the horizon, with a clear emphasis on precision medicine.

24 Sep 2021

Cardiotoxic effects of common chemotherapy drug could be prevented

Harmful side effects from a common chemotherapy drug could be the result of a single mutation, according to a study published in Cell Stem Cell.

24 Sep 2021

Scientists publish a detailed map of where human antibodies bind to SARS-CoV-2

Scientists at La Jolla Institute for Immunology (LJI) have published a detailed map of where human antibodies bind to SARS-CoV-2, a map that was generated by a global collaboration comparing nearly all leading clinical candidates.

24 Sep 2021

Trained computer program can aid physicians in accurately diagnosing breast cancer

A computer program trained to see patterns among thousands of breast ultrasound images can aid physicians in accurately diagnosing breast cancer, a new study shows.

24 Sep 2021

New mutations enable gliomas to resist proven treatment, study shows

About one-third of all brain tumors are gliomas, cancerous growths that originate in the glial cells that surround and support neurons in the brain. The prognosis for patients with gliomas is not good, with the average survival time being 12-18 months.

24 Sep 2021

Design of mRNA vaccines to combat COVID-19

A recent review study discusses fundamental concepts in the successful delivery of nucleic acids in therapeutics.

23 Sep 2021

New methodology for evaluating transmissibility and competitive advantages of co-circulating SARS-CoV-2 variants

A new study examines how SARS-CoV-2 variants confer a competitive advantage on the virus, fueling further transmission and mortality.

23 Sep 2021

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics.

23 Sep 2021

People with natural immunity and subsequent mRNA vaccination can neutralize viral particles capable of resisting vaccine-induced antibodies

New research suggests SARS-CoV-2 spike protein substitution mutations can create a replication-defective viral particle that makes the virus resistant to vaccine-induced antibodies.

23 Sep 2021

Researchers encourage longer dosing intervals for Pfizer-BioNTech’s COVID-19 vaccine

Researchers in Canada, Italy, and the United States have encouraged extending the interval time between two doses of Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine among individuals who have not previously been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

22 Sep 2021

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

A new study indicates that low-level resistance of SARS-CoV-2 to remdesivir is not widespread and dissimilar to other RNA viruses revealing evolutionary predictability of this pandemic virus.

22 Sep 2021

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

Cancer-fighting immune cells in patients with lung cancer whose tumors do not respond to immunotherapies appear to be running on a different "program" that makes them less effective than immune cells in patients whose cancers respond to these immune treatments, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Sep 2021

COVID-19 deaths in U.S. surpass 1918 Spanish Flu pandemic

The coronavirus disease (COVID-19) pandemic is most likely the deadliest outbreak in recent American history, exceeding the estimated deaths from the 1918 influenza pandemic.

21 Sep 2021

COVID-19 vaccine effectiveness against SARS-CoV-2 variants

A commentary published in the journal Cell summarizes international data on vaccine effectiveness against new severe acute respiratory coronavirus 2 (SARS-CoV-2) variants. Evidence shows that the currently approved vaccines continue to be effective in preventing severe and symptomatic illness — even with the widely circulating Delta variant.

21 Sep 2021

Mutation News and Research

Trial of Sanofi/GSK SARS-CoV-2 vaccine boosters against variants in non-human primates

A new SARS-CoV-2 variant (B.1.1.523) capable of escaping immune protections

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Characterization of SARS-CoV-2 infections diagnosed after mRNA BNT162b2 vaccination

Study reveals surfaces of SARS-CoV-2 spike most resistant to antibody escape

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Promising data from early clinical trials of new anticancer therapies presented at ESMO Congress 2021

Cardiotoxic effects of common chemotherapy drug could be prevented

Scientists publish a detailed map of where human antibodies bind to SARS-CoV-2

Trained computer program can aid physicians in accurately diagnosing breast cancer

New mutations enable gliomas to resist proven treatment, study shows

Design of mRNA vaccines to combat COVID-19

New methodology for evaluating transmissibility and competitive advantages of co-circulating SARS-CoV-2 variants

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

People with natural immunity and subsequent mRNA vaccination can neutralize viral particles capable of resisting vaccine-induced antibodies

Researchers encourage longer dosing intervals for Pfizer-BioNTech’s COVID-19 vaccine

SARS-CoV-2 genome signature leads to replicative advantage in presence of Remdesivir

Study findings could lead to novel ways to overcome tumor resistance to immunotherapies

COVID-19 deaths in U.S. surpass 1918 Spanish Flu pandemic

COVID-19 vaccine effectiveness against SARS-CoV-2 variants

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Latest News