Preclinical News and Research

RSS

Breakthrough discovery could pave the way for new non-opioid painkillers to treat neuropathic pain

Monash University researchers have made a breakthrough discovery that could pave the way for the development of novel non-opioid painkillers to safely and effectively treat neuropathic pain.

8 Sep 2021

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

A new study successfully identifies a series of inhibitors that possesses pancoronavirus activity against SARS-CoV, SARS-CoV-2, and MERS-CoV.

7 Sep 2021

New convection-enhanced MEDs could offer faster, more effective treatment for T1D patients

More than 40 million people worldwide are affected with type 1 diabetes (T1D) mellitus, an autoimmune disease in which insulin producing β-cells in the pancreas are destroyed by the immune system.

6 Sep 2021

Weill Cornell receives NIH support to advance TB research

Tuberculosis (TB) is one of the deadliest infectious diseases in history and one of the few that naturally infects only humans.

4 Sep 2021

UC cosmetic scientist receives grant to explore skin permeation of chemical agents

A researcher at the University of Cincinnati is looking at ways to make products such as anti-aging and skin lightening creams, lotions, and gels more effective.

2 Sep 2021

Study could pave way for an effective approach to amblyopia treatment

Amblyopia is the most common cause of vision loss in children, according to the U.S. National Eye Institute.

1 Sep 2021

Family of proteins could be effective in reducing damage from ischemic stroke

Boosting a family of naturally occurring proteins that dampens inflammation in the body has been shown to be effective in reducing damage from an ischemic stroke, according to preclinical researchers at The University of Texas Health Science Center at Houston.

1 Sep 2021

New candidate vaccine for COVID-19 found to be efficacious in preclinical models

More than a year after the start of the COVID-19 pandemic, several vaccines have been authorized thanks to unprecedented worldwide research efforts. These first-generation vaccines bring great hope and are a mainstay in fighting the virus.

1 Sep 2021

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

McGill University researchers identify proteins that drive cancer stem cells. Targeting and supressing a particular protein called galectin1 could provide a more effective treatment for glioblastoma, in combination with radiation therapy.

31 Aug 2021

Investigational vaccine does not provide sufficient protection against HIV infection

An investigational HIV vaccine tested in the "Imbokodo" clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data. The Phase 2b proof-of-concept study, which began in November 2017, enrolled 2,637 women ages 18 to 35 years from five countries.

31 Aug 2021

Migraine-inducing peptides may protect against diabetes by influencing insulin production

People who get migraines are less likely to develop type 2 diabetes, while some people who develop diabetes become less prone to migraines.

26 Aug 2021

An existing drug may function as targeted therapy for ALL in children

A new study from Linköping University has shown that the tumour-inhibiting gene TET2 is silenced in a large fraction of cases of acute lymphoblastic leukemia (ALL) in children.

25 Aug 2021

New artificial blood vessel platform for predicting organ transplant rejection

Organ transplantation involves the transplantation of organs from donors as a means to treat disease or injury, but there is a shortage of organs available for donation compared to the demand for organ transplantation.

25 Aug 2021

Compounds from medicinal mushrooms may be our future weapon against SARS-CoV-2

Certain steroid-like compounds from Taiwan's endemic medicinal mushrooms (known as antcins) may inhibit a host cell receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, thus, prevent viral infection and subsequent development of the coronavirus disease (COVID-19), reports a new study published in the MDPI's journal Plants.

24 Aug 2021

UCLA scientists receive $1 million translational award to advance CAR T cell therapy for rare melanomas

Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the U.S. Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.

24 Aug 2021

Researchers develop brain organoids that show neural activity similar to living human brains

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed brain organoids - 3D, brain-like structures grown from human stem cells - that show organized waves of activity similar to those found in living human brains.

24 Aug 2021

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

Amyloid plaques are protein deposits that collect between brain cells, hindering function and eventually leading to neuronal death.

23 Aug 2021

Preclinical study validates crucial role of the spleen in cardiac repair

Although we can survive without a spleen, evidence continues to mount that this abdominal organ plays a more valuable role in our physiological defenses than previously suspected.

23 Aug 2021

Leducq Foundation awards $7 million for vascular malformation research

Luisa Iruela-Arispe, PhD, the Stephen Walter Ranson Professor of Cell Biology and chair of Cell and Developmental Biology, is the North American coordinator for an international collaboration that has received a five-year, $7 million Transatlantic Networks of Excellence Program award from the Leducq Foundation.

20 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

Preclinical News and Research

Breakthrough discovery could pave the way for new non-opioid painkillers to treat neuropathic pain

Potential pancoronavirus fusion inhibitors that are effective against SARS-CoV-2 variants

New convection-enhanced MEDs could offer faster, more effective treatment for T1D patients

Weill Cornell receives NIH support to advance TB research

UC cosmetic scientist receives grant to explore skin permeation of chemical agents

Study could pave way for an effective approach to amblyopia treatment

Family of proteins could be effective in reducing damage from ischemic stroke

New candidate vaccine for COVID-19 found to be efficacious in preclinical models

Targeting and inhibiting a protein could provide more effective treatment for brain cancer

Investigational vaccine does not provide sufficient protection against HIV infection

Migraine-inducing peptides may protect against diabetes by influencing insulin production

An existing drug may function as targeted therapy for ALL in children

New artificial blood vessel platform for predicting organ transplant rejection

Compounds from medicinal mushrooms may be our future weapon against SARS-CoV-2

UCLA scientists receive $1 million translational award to advance CAR T cell therapy for rare melanomas

Researchers develop brain organoids that show neural activity similar to living human brains

Non-invasive retinal imaging may be useful for detecting Alzheimer's disease risk

Preclinical study validates crucial role of the spleen in cardiac repair

Leducq Foundation awards $7 million for vascular malformation research

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics