Cell Death News and Research

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RAC1 protein plays crucial role in proper development of mammalian lung

A study by researchers from The Saban Research Institute of Children's Hospital Los Angeles reveals a promising therapeutic target for improving lung function in infants.

21 Oct 2016

New study raises serious safety concerns in clinical use of caspase inhibitors for liver injury

Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase.

20 Oct 2016

Study unravels how caloric restriction provides beneficial effects to the brain

Studies of different animal species suggest a link between eating less and living longer, but the molecular mechanisms by which caloric restriction affords protection against disease and extends longevity are not well understood.

19 Oct 2016

Modulating immune response may help the brain to better cope with neurodegeneration

Study suggests zebrafish might teach us how to tackle Alzheimer's disease: Patients with Alzheimer's or other neurodegenerative diseases progressively loose neurons yet cannot build new ones.

19 Oct 2016

TSRI scientists elucidate how Zika virus attacks the brains of newborns

In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute have elucidated how the virus attacks the brains of newborns, information that could accelerate the development of treatments.

17 Oct 2016

Penn researchers identify new immune system mechanism to fight against infections

The innate immune system serves as a first-line defense, responding to infections almost immediately after a pathogen makes its way into the body.

17 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

Pathogenicity of fungus in plants could provide clinical information about respiratory diseases

Researchers from UPM id reveal how mould from humidity caused by rotting fruits and vegetables unfolds a surprising strategy to infect plants.

17 Oct 2016

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

13 Oct 2016

New study unravels cause of cognitive loss in tauopathy disorders

Tauopathies are a group of neurodegenerative disorders, including Alzheimer's disease that are characterized by the deposition of aggregates of the tau protein inside brain cells.

13 Oct 2016

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

A study by a multidisciplinary team of researchers from The Saban Research Institute of Children's Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody combinatorial therapy to treat this cancer.

12 Oct 2016

Novel microwave-induced photodynamic therapy could target deeply situated tumors

Physicists at The University of Texas at Arlington have shown that using microwaves to activate photosensitive nanoparticles produces tissue-heating effects that ultimately lead to cell death within solid tumors.

12 Oct 2016

UT Southwestern researchers discover protein that leads to brain cell death during stroke

One particular protein is the final executioner of events that result in the death of brain cells during stroke, researchers from UT Southwestern Medical Center and their collaborators report. This finding could ultimately lead to new ways to protect against brain damage.

7 Oct 2016

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's.

7 Oct 2016

Exposure to e-cigarette vapour induces negligible or no oxidative damage to lung epithelial cells

E-cigarette vapour is much less harmful to lung cells than cigarette smoke. Lab tests show that, unlike tobacco smoke, which causes oxidative stress and cell death, e-cigarette vapour does not. Oxidative stress and cell death are driving factors in the development of many smoking-related diseases such as COPD and lung cancer.

5 Oct 2016

BUSM scientists map active human apoptosome to provide better understanding of cell death

Programmed cell death, or apoptosis, plays a central role in the maintenance of human health by providing a line of defense against unrestricted cell growth that occurs in many cancers and AIDS as well as in neurodegenerative diseases and stroke.

4 Oct 2016

UTA research opens new doors for treatment of autoimmune diseases

Biologists at The University of Texas at Arlington have demonstrated that removing water molecules can deactivate caspase-3 enzymes, which opens new doors for treatment of autoimmune diseases like arthritis, which have been linked to overactive enzymes.

4 Oct 2016

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

A team of investigators led by researchers at Georgetown Lombardi Comprehensive Cancer Center has found, in animal models of human breast cancer, that inhibiting a single protein restores sensitivity to tamoxifen, a commonly used drug for treatment of some breast cancers.

3 Oct 2016

Research shows how new ovarian cancer treatment could help boost anti-tumor immunity

Few effective treatments have been approved to treat ovarian cancer, the deadliest of all cancers affecting the female reproductive system.

3 Oct 2016

GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

Georgetown University Medical Center today announces the U.S. Food and Drug Administration has completed its review of an investigational new drug application (IND) for the use of nilotinib in a phase II clinical trial for patients with mild to moderate Alzheimer's disease.

30 Sep 2016

Cell Death News and Research

RAC1 protein plays crucial role in proper development of mammalian lung

New study raises serious safety concerns in clinical use of caspase inhibitors for liver injury

Study unravels how caloric restriction provides beneficial effects to the brain

Modulating immune response may help the brain to better cope with neurodegeneration

TSRI scientists elucidate how Zika virus attacks the brains of newborns

Penn researchers identify new immune system mechanism to fight against infections

NAC improves effectiveness of adoptive cell therapy for treating melanoma

Pathogenicity of fungus in plants could provide clinical information about respiratory diseases

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

New study unravels cause of cognitive loss in tauopathy disorders

Study suggests possibility for small molecule drug/antibody combinatorial therapy to treat neuroblastoma

Novel microwave-induced photodynamic therapy could target deeply situated tumors

UT Southwestern researchers discover protein that leads to brain cell death during stroke

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Exposure to e-cigarette vapour induces negligible or no oxidative damage to lung epithelial cells

BUSM scientists map active human apoptosome to provide better understanding of cell death

UTA research opens new doors for treatment of autoimmune diseases

Inhibiting single protein could help restore sensitivity to common treatment for breast cancer

Research shows how new ovarian cancer treatment could help boost anti-tumor immunity

GUMC receives FDA clearance to begin clinical study of cancer drug in patients with Alzheimer's disease

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